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Dr. Bob is Robert Hsiung, MD,
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Posted by ShawnThomas on November 6, 2012, at 15:13:29
I know someone who recently quit taking amitriptyline. As a result, she is experiencing likely symptoms of cholinergic rebound such as anxiety, insomnia, nausea, diarrhea, restlessness, and feeling hot. Please note that she had only been taking 10mg/day (for multiple years) and is therefore not likely to be experiencing any withdrawal effects related to the discontinuation of serotonin or norepinephrine reuptake.
I suggested that she take Benadryl (diphenhydramine) because of its anticholinergic and antihistamine effects, and her symptoms subsequently went away. Does anyone have any suggestions about how long she should continue to take Benadryl? Can anyone suggest a good dosage and tapering schedule?
Posted by jono_in_adelaide on November 6, 2012, at 20:29:58
In reply to Cholinergic rebound after amitriptyline withdrawal, posted by ShawnThomas on November 6, 2012, at 15:13:29
Current dose for 1 week
3/4 of current dose for 1 week
1/2 of current dose for 1 week
1/4 of current dose for 1 week
Stop.
Posted by ShawnThomas on November 7, 2012, at 1:23:28
In reply to Re: Cholinergic rebound after amitriptyline withdrawal, posted by jono_in_adelaide on November 6, 2012, at 20:29:58
Thanks Jono, I will pass that suggestion along.
Posted by Phil on November 7, 2012, at 11:11:38
In reply to Re: Cholinergic rebound after amitriptyline withdrawal » jono_in_adelaide, posted by ShawnThomas on November 7, 2012, at 1:23:28
I was on 250 mg for 5 years and luckily had no issues that I can remember..long time ago.
This is the end of the thread.
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