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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by poser938 on November 3, 2012, at 0:44:23
Tonight I took my 1st dose of 0.14mgs intranasal Fluazenil to help combast the longterm effects Mirapex had on me. My docand I believe it basically shut dwn my dopamine neurotransmission. So far, no luck with, though. I don't think I felt anything from it.
I have weondered if it could have something to do with the route of administration? For normal use it is injected but sdtudies have been on nasasl form. Some showed it worked about as well as injection and one I found said it didn't work nearly as well. I
This studt I found is a PDF article and would have to be downloaded. Type in 'clinical trial of intranasal flumazenil' and it should show up as one of the top choices'.
It says out of 25 people in the study, only 2 of them responded completely to the intranasal Flumazenil.I'm wondering.. isn't intranasal supposed to be just as effective as intraveinous when taking medications?
I found it odd yoo because it said that peak serum levels were reached within 10 minutes, yet it still wasn't very effective.
Posted by phillipa on November 3, 2012, at 9:42:32
In reply to intranasal Flumazenil VS intraveinous, posted by poser938 on November 3, 2012, at 0:44:23
What is it? And IV to me would work fastest basing this on how anesthesia is given via IV. Phillipa
Posted by phillipa on November 3, 2012, at 9:44:22
In reply to intranasal Flumazenil VS intraveinous, posted by poser938 on November 3, 2012, at 0:44:23
Google brings this med up for benzo Od? Phillipa
Posted by poser938 on November 3, 2012, at 13:17:06
In reply to Re: intranasal Flumazenil VS intraveinous » poser938, posted by phillipa on November 3, 2012, at 9:44:22
Yup, it is used to block the GABA receptors when someone overdoses on a benzo. My psychiatrist and I are interested in its ability to isinhibit dopamine release. It has been studied in parkinsons disease and has been found to help. It also reverses the dopamine deficit caused by chronic benzo use.
We are hoping it will reverse my dopamine deficit causex by chronic Mirapex use. Normal dopamine raising haven't had any effect on me lately, so we are now trying Flumazenil.
Posted by linkadge on November 3, 2012, at 18:52:27
In reply to Re: intranasal Flumazenil VS intraveinous, posted by poser938 on November 3, 2012, at 13:17:06
Your low dopamine (if this is even the problem) may not be related to elevated gaba.
Other possible (numerous) factors causing / resembling diminished dopamine function include:
- poor dopamine synthesis (genetic)
- deficiancy in dopamine precursors or co-factors
- altered metabolic homeostasis (MAO, COMT, DAT)
- diminished p11 (5-ht1b) receptor expression
- elevated acetylcholine (at muscarinic receptors)
- diminished acetlycholine (at nicotinergic receptors)
- enhanced rem sleep
- elevated cortisol
- elevated glutamate (diminished NMDA gating)
- lowered d2 expresssion or sensitivity (fatty acid imbalance / deficiancy)
- elevated 5-ht2c inhibitory expression
- elevated serotonergic activity at 5-ht2c
- diminished cannabanoid signaling (cb1)
- diminished cannabanoid synthsis / metabolism
- diminished opioid receptor signalling
- reduced GDNF expression
- reduced BDNF expression
- diminished PKC activity
- diminished 2nd mesenger signaling (inositol)
- diminished GSK-3b expression
- undermethylation (SAMe deficiancy)
- vitamin deficiancy (ie b6, b12, vitamin d, iron)
- diminished antioxidant status
- inflamation
- testosterone deficiancy
- growth hormone deficancy
- DHEA deficiancy
- subclinical insulin resistance
- phenylethylamine deficiancy
- adrenal insufficiancy
- etc, etcOr, your problem might not be related to dopamine at all......
Linkadge
Posted by poser938 on November 3, 2012, at 22:06:29
In reply to Re: intranasal Flumazenil VS intraveinous, posted by linkadge on November 3, 2012, at 18:52:27
What caused the problem was psychiatric medications I had been prescribed. I have "tardive dysphoria".
Now, why my brain reacts like this to medications, that's something i'd love to know. I know because of mirapex my dopamine synthesis is low. The uestion is, how to reverse this problem. Cyproheptadine used to work incredibly, but I got to a much too high dose of it.
My doc and I tried to get past this with transdermal gel cyproheptdine, it didn't help in that form.
Now i'm considering intranasal cyproheptadine, but I'm worried because with my experience with Ketamine, when spraying it in my nose sometimes it seemed to go to the back of my throat and to my stomach. I need to get an exact dose every time. I wish there were a more direct way, similar to how someone is fed with a feedng tube.Linkadge, what happens to dopamine when its presynaptic receptors are over-stimulated my chronic medication?
Posted by poser938 on November 3, 2012, at 22:27:50
In reply to Re: intranasal Flumazenil VS intraveinous, posted by linkadge on November 3, 2012, at 18:52:27
And judging pasrtly by how bad my typing skills are getting (if you haven't noticed) I am in sore need for the awesome 5ht2c blocking abilities thst cyproheptadine has and its effects, as you mentioned, in dopamine. Or maybe it was the calcium channel blockin.
Posted by jono_in_adelaide on November 4, 2012, at 5:45:14
In reply to Re: intranasal Flumazenil VS intraveinous, posted by poser938 on November 3, 2012, at 22:06:29
You seem to be making a lot of assumptions without much to support them
Posted by linkadge on November 4, 2012, at 14:10:37
In reply to Re: intranasal Flumazenil VS intraveinous, posted by poser938 on November 3, 2012, at 22:06:29
>I know because of mirapex my dopamine synthesis >
>is low.Mirapex doesn't affect the synthesis of dopamine to any great extend (that I know).
Also, cyproheptadine behaves like an antipsychotic in animal models, so I don't think that I has any profound dopamine boosting effect.
Have you considered the possiblity that you have psychotic depression? This would explain the strong - but seemingly unfounded - belief that mirapex is to blame for all your suffering. It would also explain why a dopamine agonist would make things worse.
If dopamine was your problem....then why would mirapex (a dopamine enhancing medication) make your condition worse? How did you feel *on* the mirapex? Why did you decide to come off?
Have you tried something like fluvoxamine?
Linkadge
Posted by phillipa on November 4, 2012, at 21:27:11
In reply to Re: intranasal Flumazenil VS intraveinous, posted by linkadge on November 4, 2012, at 14:10:37
You like luvox? Phillipa
This is the end of the thread.
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