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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by rjlockhart04-08 on July 31, 2012, at 11:50:56
i don't mean to write this directly to you...its just I am having a difficult time and I realize that some things on this subject are limted here on babble, i've got to find some other website to post whats going on with this. But let me get to the point...my meds like I said have begined to take long times to take a effect and sometimes its a miminial effect or no effect at all. Right now...i took my Nuvgil and I do notice somewhat of a diffrence, but many times through the past months it would have no effect at all, and that's why I have started to think its a digestive issue and so I started putting it under my tongue...ugh it is nasty...sometimes I just had force myself to swallow because of the horrible taste. But my question...i've came to concluesion that even somtiems when I put it under my tongue it still has minimal effect....its like its not passing through the blood brain barrier, or not being absorbed sometimes into the brain cells. I'm vary resistant to various medications, once and while it will have an effect...but its not like it was a couple years ago. So I did some research and their is couple things that I found...one that their could be a virus in the intrestines...that's preventing it to work...but I cancel that out because when I started putting it under my tongue it still was similar as if I ingested it. The next thing is the body has created a resistance against it, through some kinda of hormonue or enzyme to block the medication. Still right now the Nuvgil has taken effect, but its not its fullest...
But I mean what do you....whats your educated view of this, and if it keeps up what doctor do I need to see? of corse lately I have been praying to God of Israel and Jesus Christ to heal this condition and I have to say their have been awnsered prayers...and I don't want to end my faith, but I just need some resources on what to do about this in medical terms. Thank you for reading...
rj
Posted by SLS on July 31, 2012, at 12:35:26
In reply to SLS...Larry Hoover...Jedi...Dr. Bob, posted by rjlockhart04-08 on July 31, 2012, at 11:50:56
To look at an alternative explanation:
The drugs you take are crossing your blood-brain barrier in a normal manner. However, your brain has become desensitized to these drugs due to multiple exposures to them. Even side effects can disappear. In other words, your brain has become tolerant to psychotropics. This sort of thing happens with other classes of drugs, including antibiotics. The mechanisms are different, but the net effect is the same. Cross-tolerance can become a factor with all of these drugs. It manifests as a decrease in the response to one drug due to exposure to another drug. Being exposed to Paxil can make someone less responsive to other SSRIs.
Your drugs are getting into your brain. They just aren't producing the changes in your condition(s) that you would like to see. The biological reasons for this have yet to be elucidated. In this respect, you are part of the majority of people posting on Psycho-Babble.
As to your spirituality, look for hope and positive energy wherever you can find it. I have found quite a bit in my own spirituality. It just seems to help. Studies of people suffering with depression have documented that this happens. The results reported indicated that it did not matter which spiritual or religious beliefs were followed in order to see a positive effect. However, simply attending a house of worship was not sufficient to produce a therapeutic or protective effect. There had to be some sort of psychological participation.
- Scott
Posted by brynb on July 31, 2012, at 21:43:00
In reply to SLS...Larry Hoover...Jedi...Dr. Bob, posted by rjlockhart04-08 on July 31, 2012, at 11:50:56
Hey rj,
I tend to agree with Scott regarding multiple exposure to meds and desensitization. It seems to be a good explanation for resistance.
Also, I've seen your posts about struggles with substance abuse. Awhile back, I had a problem too (I'm clean now and have been for years), and I can say (quite confidently) that when using any illegal drugs (or addictive meds/pills in copious amounts), it's impossible to know what's going on psychiatrically, let alone to try and treat it. Even occasional use will tip the scales. I sort of outgrew the addiction, and got to the point where my brain chemistry simply couldn't handle it anymore. But I'm not judging! If you're clean, great, then it's not the drugs; if not, that's okay too, but don't expect to figure things out if you're still using.
Another thought I had when reading your post is the med "food" Deplin. It supposedly helps those with a folate deficiency (because they can't break it down properly), seemingly common amongst depressed people. It is marketed as a way of making psych meds more effective (I believe it helps the brain to naturally produce more serotonin, norepinephrine and dopamine). So, maybe that's an option. I tried it awhile ago, and didn't notice a real difference, but it's possible I didn't give it enough time.
Either way, good luck, and hopefully others here have some more valuable info!
-b
Posted by jane d on August 1, 2012, at 2:08:37
In reply to SLS...Larry Hoover...Jedi...Dr. Bob, posted by rjlockhart04-08 on July 31, 2012, at 11:50:56
I wonder if your problem might be in how you expect your medications to make you feel. I used to take provigil which is almost the same as nuvigil. I never felt very much when taking it but at the end of the day I'd notice that I'd done more than I would have on days I didn't take it. However on a day when I didn't need to do anything I wouldn't feel like I'd taken anything.
Something similar happens when I take antidepressants. I've never woken up happy. What has happened is after a period of weeks I suddenly realize that I haven't felt suicidal in days. Or something silly that would have made me very angry before doesn't anymore. But I don't feel different from minute to minute. I feel like I've always been that way unless I find specific things to measure - like how often I got angry. Or how many days I couldn't go to work.
This is a very different feeling from anything I've felt using recreational drugs where all of a sudden I would feel mellow or think that I was brilliant. Until the drugs wore off.
Perhaps when you are prescribed a new drug you can ask your doctor what you should expect to feel when it's working and how soon you should feel it.
Good luck.
Jane
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