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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by poser938 on May 29, 2012, at 14:56:38
i've been trying to look information on this, and i have found some information that medication put in transdermal patch form does bypass the liver, and some sites saying it doesnt.
Posted by europerep on May 29, 2012, at 16:18:00
In reply to does a transdermal patch bypass the liver, posted by poser938 on May 29, 2012, at 14:56:38
They probably mean that transdermal application avoids first-pass metabolism, because the drug directly enters the bloodstream. But the drug will still go through the liver eventually on its way through the system.
Did that help?
Posted by Phillipa on May 29, 2012, at 16:54:59
In reply to Re: does a transdermal patch bypass the liver » poser938, posted by europerep on May 29, 2012, at 16:18:00
Yes pretty sure this is what it means Phillipa
Posted by Zyprexa on May 29, 2012, at 20:56:45
In reply to does a transdermal patch bypass the liver, posted by poser938 on May 29, 2012, at 14:56:38
I'm pretty sure it does go through the liver. It would have to, to be broken down.
Posted by poser938 on May 30, 2012, at 18:39:54
In reply to Re: does a transdermal patch bypass the liver » poser938, posted by Zyprexa on May 29, 2012, at 20:56:45
so, let me see if i can word this right... does that mean that the liver doesnt have to work as hard since it avoids "first-pass metabolism"? and that it can tolerate medication better? i'm curious because i may be starting high doses of cyproheptadine that i'm getting in transdermal form from a compounding pharmacy.
Posted by Phillipa on May 30, 2012, at 21:07:03
In reply to Re: does a transdermal patch bypass the liver, posted by poser938 on May 30, 2012, at 18:39:54
Poser a good question as it would seem so? But I don't think I've ever seen an answer? Phillipa
This is the end of the thread.
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