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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Poser938 on April 9, 2012, at 14:41:07
I just got back from my pdoc and he raised the dose. I can't remember the dose exactly... I think it's 300mgs I'm taking intranasally now. I asked him about the low doses that have been given through i.v. In studies, and he said that since I'm taking it nasally, a higher dose is needed. He also did say it would function a bit differently if it is injected.
But maybe this high dose is what I need. Maybe I just need to be disconnected for a little while. We will see.
Posted by Phillipa on April 9, 2012, at 16:18:14
In reply to Ketamine dose was raised, posted by Poser938 on April 9, 2012, at 14:41:07
Poser the very best of luck. May this be the one for you. Phillipa
Posted by europerep on April 10, 2012, at 7:33:35
In reply to Ketamine dose was raised, posted by Poser938 on April 9, 2012, at 14:41:07
As far as I know, there is no evidence whatsoever for using 300mg of ketamine intranasally to treat depression. This is a dose that should also produce potent psychoactive effects, so I'm not even sure whether it could be given to people if it *were* effective for depression. Experience reports of successful use of ketamine for depression (IN or otherwise) are with amounts in the two-digit milligramm sector, and mostly even in the low two-digit sector. I am pretty sure that your current regimen is not going to produce the effects you hope for.
As I said earlier, I think the dose that your doc started you on was already too high. I'm not a doctor, so I'm not going to tell you how to use ketamine, but I think you should prepare yourself for the realization that ketamine won't work for you. I'm really sorry, but I think this is what it is. The difference in bioavailability between IV and IN is not so huge that doses of 100mg, or even multiples of that, would be equivalent to low-dose IV ketamine. If anything, going lower with your dose would seem appropriate.
Posted by sigismund on April 10, 2012, at 15:15:41
In reply to Re: Ketamine dose was raised » Poser938, posted by europerep on April 10, 2012, at 7:33:35
Still, whether it is effective for depression or not, you would know that you had had it, way beyond feeling woozy or whatever it was.
25mg IV, IIRC after all this time, you are no longer *there* for it. Maybe there is a big difference between these types of admin?
Posted by poser938 on April 10, 2012, at 16:53:07
In reply to Re: Ketamine dose was raised » Poser938, posted by europerep on April 10, 2012, at 7:33:35
i have started talking to the pharmacist that works at the compounding pharmacy where i get the ketamine. he is also the owner of the place, and he seems very smart. if im understanding hm and my doctor correctly, 300mgs of ketamine intrnasally isnt as strong as a low dose around 35mgs in an i.v.
i took the 300mgs last night and once again all it did was make me dizzy. i am considering having one of my friends help me inject a dose of around 20mgs or a bit more of it. i dont know how this sounds to others, but i am definitely needing to take action and move beyond doses that just make me dizzy. i am feeling terrible...
the pharmacist also mentioned an idea he has, that he's going to do some research on after i told him how Mirapex had caused this problem for me, and Adderall did the same thing in the past. he said his idea involves "methylation". i'm not sure what that is, but im going to do some research on it.
i know that basically, my dopamine system is shut down. i cant even feel the effects of the multiple antipsychotics ive tried.
Posted by poser938 on April 10, 2012, at 16:59:53
In reply to Re: Ketamine dose was raised, posted by poser938 on April 10, 2012, at 16:53:07
i just read about methylation a little bit and i dont know what he means by it. but he started talking about this after i told him how cyproheptadine had helped me a a lot, and that i got to a very high dose on it because i would get tolerant to a dose fast. all he mentoned that his idea involves methylaton.
Posted by poser938 on April 10, 2012, at 17:46:53
In reply to Re: Ketamine dose was raised, posted by poser938 on April 10, 2012, at 16:59:53
http://en.wikipedia.org/wiki/DNA_methylation
i guess this is what my pharmacist was taking about.
Posted by poser938 on April 10, 2012, at 18:29:26
In reply to Re: Ketamine dose was raised, posted by poser938 on April 10, 2012, at 16:53:07
... well perhaps i wont be injecting the ketaminemyself... it seems that would be a bad idea after reading about it. i am just getting desperate....
Posted by Hugh on April 11, 2012, at 12:43:16
In reply to Re: Ketamine dose was raised, posted by poser938 on April 10, 2012, at 17:46:53
> http://en.wikipedia.org/wiki/DNA_methylation
>
> i guess this is what my pharmacist was taking about.I'd never heard of DNA methylation before. I just found this at
http://esciencenews.com/articles/2008/07/30/study.identifies.changes.dna.major.depression.and.suicide"The rate of [DNA] methylation in the suicide brains was found to be much greater than that of the control group."
It looks like most of the research on DNA methylation has been done by cancer researchers.
Sulforaphane, which is found in high levels in broccoli sprouts, helps to normalize DNA methylation. There are sulforaphane supplements and broccoli sprout extract supplements available online.
Posted by poser938 on April 12, 2012, at 16:38:53
In reply to Re: Ketamine dose was raised -- DNA methylation, posted by Hugh on April 11, 2012, at 12:43:16
yah i just dont understand where my pharmacist is going with this.
all he said is his idea involves "methylation".
i guess i could go talk to him some more, but i'm feeling very timid lately, and just unconfident. i feel like i will end up getting on his nerves or something.
This is the end of the thread.
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