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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by crazyjoe on March 25, 2012, at 14:21:18
what is it about klonopin that makes it cause more depression in people than say ativan/zanax
Posted by Phillipa on March 25, 2012, at 19:43:14
In reply to klonopin/depression, posted by crazyjoe on March 25, 2012, at 14:21:18
Don't know but I felt suicidal on it and wasn't stopped back to xanax and fine. Phillipa
Posted by gadchik on April 1, 2012, at 9:21:44
In reply to Re: klonopin/depression » crazyjoe, posted by Phillipa on March 25, 2012, at 19:43:14
I feel great on klonopin .5mg daily.No depression.
Posted by phidippus on April 3, 2012, at 19:10:54
In reply to klonopin/depression, posted by crazyjoe on March 25, 2012, at 14:21:18
It inhibits serotonin production, acting like a uptake inhibitor at certain sites.
Eric
Posted by Phillipa on April 3, 2012, at 21:13:26
In reply to Re: klonopin/depression » crazyjoe, posted by phidippus on April 3, 2012, at 19:10:54
Eric does that mean you would get less serotonin from an SSRI as if so that would be why klonopin depressed me in a day or so. So wouldn't it also mean I need serotonin? Thanks Phillipa
Posted by gadchik on April 4, 2012, at 8:14:41
In reply to Re: klonopin/depression » crazyjoe, posted by phidippus on April 3, 2012, at 19:10:54
> It inhibits serotonin production, acting like a uptake inhibitor at certain sites.
>
> Eric
I take it that it means k blocks some serotonin sites,but does it actually lower it? I dont understand why some get depressed and others feel better on k? And also why is an ssri is prescribed along w/k if it blocks the uptake?
Posted by SLS on April 4, 2012, at 8:39:31
In reply to Re: klonopin/depression, posted by gadchik on April 4, 2012, at 8:14:41
> > It inhibits serotonin production, acting like a uptake inhibitor at certain sites.
> >
> > Eric
> I take it that it means k blocks some serotonin sites,but does it actually lower it? I dont understand why some get depressed and others feel better on k? And also why is an ssri is prescribed along w/k if it blocks the uptake?
>If my memory serves me, clonazepam (Klonopin) inhibits the release of serotonin, thus reducing the concentration of this neurotransmitter in the synaptic cleft. The resulting effects are opposite to that of a SRI.
- Scott
Posted by gadchik on April 4, 2012, at 9:26:05
In reply to Re: klonopin/depression » gadchik, posted by SLS on April 4, 2012, at 8:39:31
I know I tapered zoloft,and then feel fine on just the klonopin. Perhaps serotonin was not my issue,but I also felt fine on zoloft/k.But maybe the serotonin enhancing of z was canceled out by k?Sorry,more confusion.I am fascinated by it though.
Posted by Phillipa on April 4, 2012, at 18:42:20
In reply to Re: klonopin/depression, posted by gadchik on April 4, 2012, at 9:26:05
Same here you are not alone!!! Phillipa
Posted by phidippus on April 5, 2012, at 16:16:08
In reply to Re: klonopin/depression » phidippus, posted by Phillipa on April 3, 2012, at 21:13:26
Yes, Klonopin competes with SSRIs when it comes to serotonin. I wouldn't be surprised if you felt depressed on Klonopin while you took it.
You have OCD. You need serotonin.
Eric
Posted by Phillipa on April 6, 2012, at 19:16:32
In reply to Re: klonopin/depression » Phillipa, posted by phidippus on April 5, 2012, at 16:16:08
Thank you!!!! Phillipa
Posted by crazyjoe on April 7, 2012, at 21:47:49
In reply to Re: klonopin/depression » phidippus, posted by Phillipa on April 6, 2012, at 19:16:32
really interesting in theory then klonopin really stops one from getting the total serotonin benefit of an ssri and i did read from a dr. that it could cause depression. in doses over 2mg ...interesting
Posted by mogger on April 10, 2012, at 12:10:57
In reply to Re: klonopin/depression, posted by crazyjoe on April 7, 2012, at 21:47:49
I agree it is fascinating. My pdoc put me on klonopin for ocd with my zoloft as he said there is a synergy. I don't feel that it has been particularly helpful although it does help with the chatter with my ocd and hasn't caused depression for me. He put me onto this study.
Posted by gadchik on April 11, 2012, at 17:28:39
In reply to Re: klonopin/depression, posted by mogger on April 10, 2012, at 12:10:57
Thanks for that link.I found that reassuring.I take klonopin daily.Im going to read the other links to the right of it as well.
This is the end of the thread.
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