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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by poser938 on March 29, 2012, at 17:27:05
and it didn't do a thing. i've been wondering what the big difference between ketamine and dextromethorphan is, and with the 100mgs i took last night, there wasn't a single difference.
i'm supposed to go up to 4 sprays after tonight, which will be 200mgs, and hopefully i will get some benefit from it.
Posted by poser938 on March 29, 2012, at 17:36:29
In reply to took 1st dose of Ketamine last night, posted by poser938 on March 29, 2012, at 17:27:05
one thing that always worries me with meds though, i storing them correctly. with the ketamine, after i picked it up from the pharmacy i put it in the center console in my car and brought it home. when i got home i took the groceries inside and saw what looked like a prescription bag inside one of the grocery bags, s i figured i mistakenly put it the ketamine in the grocery bag. 20 minutes later i noticed it wasn't the ketamine, so i went out to get it and it had gotten a bit warm from being in the car.
i might be a bit too obsessive about some thing like this lately, but i guess i can't really help it right now. i get like this when I'm feeling really bad.
Posted by novelagent on March 30, 2012, at 4:32:35
In reply to Re: took 1st dose of Ketamine last night, posted by poser938 on March 29, 2012, at 17:36:29
Poser,
I've been hospitalized for something else, but two kids in my ward who took ECT for depression noticed night and day differences from the very first day of taking it.
So your life isn't riding om ketamine-- it may work, it may not, or it may have too many side effects. That's okay, ECT is still an option, and trust me, it's a very good option. I went to the top hospital in the world, and there's a reason why its Harvard pdocs use ECT-- it works. And you can take it without doing a hospital stay at all. So that's an option if this doesn't work, so this isn't life or death.
> one thing that always worries me with meds though, i storing them correctly. with the ketamine, after i picked it up from the pharmacy i put it in the center console in my car and brought it home. when i got home i took the groceries inside and saw what looked like a prescription bag inside one of the grocery bags, s i figured i mistakenly put it the ketamine in the grocery bag. 20 minutes later i noticed it wasn't the ketamine, so i went out to get it and it had gotten a bit warm from being in the car.
>
> i might be a bit too obsessive about some thing like this lately, but i guess i can't really help it right now. i get like this when I'm feeling really bad.
Posted by SLS on March 30, 2012, at 5:55:14
In reply to took 1st dose of Ketamine last night, posted by poser938 on March 29, 2012, at 17:27:05
> and it didn't do a thing. i've been wondering what the big difference between ketamine and dextromethorphan is, and with the 100mgs i took last night, there wasn't a single difference.
>
> i'm supposed to go up to 4 sprays after tonight, which will be 200mgs, and hopefully i will get some benefit from it.
I would not be too pessimistic at this juncture unless it is unequivocal that ketamine administered as you are dong now should work within 48 hours or not work at all.Ketamine, when administered IV according to the new protocols, can produce an improvement in as little as 4 hours. I would not compare one route of administration to the other.
I wish you the best.
- Scott
Posted by poser938 on March 30, 2012, at 19:52:20
In reply to Re: took 1st dose of Ketamine last night, posted by SLS on March 30, 2012, at 5:55:14
Scott, so you're saying that nasal administration may work differently than IV? i've wondered about this myself. like if i might get different effect from injecting it. i have another appointment with the doc in a bit over a week.. i will see what he thinks.
i've been wondering what i could try next if this doesn't work. i'm scared to death of doing ECT. it seems there is about a 50% chance of it working for me, but to be honest, in my opinion i think there's even less of a chance of it helping.
i just wish i could have a god doc that understands that i really am like this from long term effects from meds. one thing my current pdoc said last monday was that, when starting a med, you will get all the effects from a med during the beginning of taking a med. and that new effects side effects would not occur after being on the med a couple of weeks. he was saying this after i told him about mirapex, because the 1st couple of weeks of me taking it all i had was increased libido from it and then after taking my dose one day, my emotions went blank.i like to think it would make a difference if they understood that the meds i took caused me to be like this. but i just dont know. this pdoc has 2 awards on his wall from the past 2 years for "best psychiatrist", i dont know how good a doc has to be to get an award like that, but hopefully he's good. i just dont want to end up doing ECT.
Posted by poser938 on March 30, 2012, at 20:03:19
In reply to Re: took 1st dose of Ketamine last night, posted by poser938 on March 30, 2012, at 19:52:20
well, one effect i think i might be getting from the ketamine is dizzieness. im not sure though. but i've already been feeling pretty bad and kinda dizzy at times before trying the ketamine.
Posted by SLS on March 30, 2012, at 20:30:54
In reply to Re: took 1st dose of Ketamine last night, posted by poser938 on March 30, 2012, at 19:52:20
> Scott, so you're saying that nasal administration may work differently than IV?
It might be a matter of reaching a certain threshold of biological activity. Perhaps it is like ECT in that, unless you reach a miniumum level of stimulation, nothing happens.
How much ketamine do you take at once? Is it less than 0.5 mg/kg body weight?
- Scott
Posted by poser938 on March 30, 2012, at 20:53:48
In reply to Re: took 1st dose of Ketamine last night » poser938, posted by SLS on March 30, 2012, at 20:30:54
i was just reading into this. i converted kgs to lbs, and if i did it right it is about 71 kgs. at 0.5 kgs i should be taking i think 35.5 mgs.
but, im on 100mgs to start and then i go to 200mgs. do you think he might be using too high a dose on me?
Posted by poser938 on March 30, 2012, at 22:13:20
In reply to Re: took 1st dose of Ketamine last night, posted by poser938 on March 30, 2012, at 20:53:48
i weight 156 pounds, so im pretty sure that's a bit over 71kgs?
Posted by SLS on March 30, 2012, at 23:53:43
In reply to Re: took 1st dose of Ketamine last night, posted by poser938 on March 30, 2012, at 22:13:20
> i weight 156 pounds, so im pretty sure that's a bit over 71kgs?
Your math is fine.:-)
Are you supposed to take 100 - 200 mg all at once?
- Scott
Posted by poser938 on March 31, 2012, at 13:34:05
In reply to Re: took 1st dose of Ketamine last night » poser938, posted by SLS on March 30, 2012, at 23:53:43
yeah, it's supposed to be all at once. it's a nasal spray, and each spray is 50mgs. and im supposed to start with 1 spray in each nostril. and then move up to 2 sprays in each nostril.
i tried researching, but i cant find much info on lowers doses and how they effect the brain compared to higher doses. do you know anything on this? such as how it effects dopamine?
Posted by europerep on March 31, 2012, at 14:28:41
In reply to Re: took 1st dose of Ketamine last night, posted by poser938 on March 30, 2012, at 19:52:20
> Scott, so you're saying that nasal administration may work differently than IV?
Personally, I doubt that. Not trying to bring you down here, but intranasal use is pretty much equivalent to IM or IV where both routes of administration have been compared. That is for example the case for pediatric anaesthesia (anaesthesia for kids). The only thing is that IN use probably has a somewhat lower bioavailability. However, your starting dose of 100mg is high, if not very high. So I doubt you have just taken too little.
Continue using it the way your doctor prescribed, but it's really as I said to JohnLA, ketamine is not a miracle drug, even if some articles in journals sound as if it were. I know what it's like to be disappointed from the effects you got from ketamine, so I'm sorry about that. But don't give up!
This is the end of the thread.
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