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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by ynwa on February 7, 2012, at 13:29:42
after two weeks of 1-1-1 every 8 hours, my doc put me on 60mg. But he has no experience with this drug so he adviced to take 2x15 in the morning , than 15mg at 4pm and one before sleep. Can anybody give hints how to take it in order to achieve best effects? Thank you very much for any advice!!!And apology my english please,it´s not my first language.
Posted by atypical on February 7, 2012, at 14:58:04
In reply to nardil dosage, posted by ynwa on February 7, 2012, at 13:29:42
Taking 2 in the morning and 1 and night is fine. I take 2 in the morning and 2.5 at night. Good luck. This medication usually helps. The side effects can be significant, but they can pass with time.
Posted by ynwa on February 8, 2012, at 1:40:05
In reply to Re: nardil dosage, posted by atypical on February 7, 2012, at 14:58:04
Thank you very much for your advice. I am on nardil for 12days and my side effects actually turned into positive effects(I could not sleep for 2days before, in one month I lost about 6kilous.)Now I my sleep is right and I eat normally(even that i expect to be craving for food at 60 or more, i do exercise).
Can someone post any more experiences with dosage of nardil? I would be most grateful.
Posted by reflecting on February 8, 2012, at 1:56:13
In reply to Re: nardil dosage, posted by ynwa on February 8, 2012, at 1:40:05
Personally I take all my 15mg doses distributed over the day with at least 45 min between two tablets. But that is because I got after some time blood pressure peaks from taking more than one tablet at a time... this seems to be very rare, however, and is typically not a problem.
Posted by jono_in_adelaide on February 8, 2012, at 16:20:24
In reply to nardil dosage, posted by ynwa on February 7, 2012, at 13:29:42
For somthing novel, try following your doctors instructions?
Posted by ynwa on February 9, 2012, at 1:58:27
In reply to Re: nardil dosage, posted by jono_in_adelaide on February 8, 2012, at 16:20:24
My doctor never prescribed this med to anyone. It´t not even registered here in the Czech republic anymore(took it off the market more than 20years ago). He confessed that he does not have actually a clue about a real dosage and have to deduce it from similar medication. In first meeting with nardil in my hands he even tried to dose it as parnate and if i did not have official documents about it from pfizer, I would be now on completely irrelevant dosage. He adviced very cautiously to increase the dosage to 60mg(after 2weeks on 45mg) with taking 2-1 and 1before sleeping. But I don´t believe his advices concerning the dosage, he showed that he actually don´t know. And no,I can´t change my doctor.It´s hard to prescribe this medication even in country where it´s registered and he is taking considerable risk here - just one serious contraindication(although I´m perfectly informed)and he would be in troubles. It would be impossible to find another doc who would like to participate in it.
That´s why I try to find more information about dosage here from users who have considerable experience.Sorry for my novel,but I wanted to put it across. Also sry for my english, it´s not my first language.
Any knowledgeable advice would be most welcomed and appreciated(and don´t worry, I am very critical and if someone tells me to take 120mg at once, I wouldn´t do it)
Posted by ynwa on February 9, 2012, at 2:13:50
In reply to Re: nardil dosage, posted by ynwa on February 9, 2012, at 1:58:27
Also I won´t rise my dosage from 60mg by myself after less than four weeks on it(it´s been only two days since I am on 60mg, together it´s about 2weeks since i started taking it.
It´s the way how to distribute it through the day what makes me worried. He adviced to take 2at the morning, 1 at 4p.m. and one before i go to sleep. I take it 2at the morning and 2 at 4p.m.,because it started to cause me insomnia.
I think that the most essential is just to take it every day and split it up to two or three rations so it will be still in my body. But yet, someone who knows much about this drug and gives me proper view into dosage of 60mg would help me(but still i would have to decide from all the posts)
Posted by SLS on February 9, 2012, at 5:44:13
In reply to Re: nardil dosage, posted by ynwa on February 9, 2012, at 2:13:50
Many people need 75-90 mg of Nardil (phenelzine).
As a rule, one can take 1 mg/kg of body weight.
- Scott
http://www.ncbi.nlm.nih.gov/pubmed/365127Arch Gen Psychiatry. 1978 May;35(5):629-35.
Clinical pharmacology of phenelzine.
Robinson DS, Nies A, Ravaris CL, Ives JO, Bartlett D.
AbstractThere is renewed interest in the clinical pharmacology of phenelzine sulfate and other monoamine oxidase (MAO) inhibitors. Newer clinical and analytic techniques recently have been applied to investigations of this class of drugs in man. The results show that drugs such as phenelzine are effective in nonendogenous depression and phobic disorders. Clinical response to phenelzine is related to platelet MAO inhibition and dosage per unit body weight. High percent MAO inhibition in platelets at two weeks is associated with greater improvement after a six-week course of treatment. Our data show that a safe, effective phenelzine dose in 1 mg/kg body weight per day. These results have delineated the pharmacologic and therapeutic effects of phenelzine and support a continuing role for MAO inhibitors in psychopharmacology.
Posted by ed_uk2010 on February 9, 2012, at 18:58:52
In reply to Re: nardil dosage, posted by ynwa on February 9, 2012, at 1:58:27
Ahoj, dobry vecer! (I had to remove the accents because psycho-babble does not support them)
Since Nardil is not available in the Czech Republic, your doctor will need to follow the dosage guidelines from another country.
The dosage recommendations from the US are available online.
http://www.rxlist.com/nardil-drug/indications-dosage.htm
'Initial dose: The usual starting dose of NARDIL (phenelzine) is one tablet (15 mg) three times a day.
Early phase treatment: Dosage should be increased to at least 60 mg per day at a fairly rapid pace consistent with patient tolerance. It may be necessary to increase dosage up to 90 mg per day to obtain sufficient MAO inhibition. Many patients do not show a clinical response until treatment at 60 mg has been continued for at least 4 weeks.'
The bit about the 'maintenance dose' should be ignored because it is no longer recommended to reduce the dose of antidepressants once the patient has improved. This is an old-fashioned idea. Current opinion is that the antidepressant should be continued at the dose which was effective in treating the depressive episode.
This is the end of the thread.
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