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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by mogger on January 18, 2012, at 14:35:22
Hello there,
Has anyone had success taking both an SSRI combined with 5htp and at what dose? My nutritionist says that she has seen many of her patients combine the two safely without the risk of serotonin syndrome. She pointed out this study as well.
Psychoneuroendocrinology. 2006 May;31(4):473-84. Epub 2005 Dec 27.
L-5-Hydroxytryptophan augments the neuroendocrine response to a SSRI.
Lowe SL, Yeo KP, Teng L, Soon DK, Pan A, Wise SD, Peck RW.
Lilly-NUS Centre for Clinical Pharmacology, Level 6, Clinical Research Centre (MD11), National University of Singapore, 10 Medical Drive, Singapore, Singapore 117597. lowe-stephen@lilly.comThe objective of the study was to assess l-5-hydroxytryptophan's (l-5HTP) augmentation effect on the neuroendocrine response to a SSRI (citalopram). A neuroendocrine challenge study was conducted in healthy Asian male subjects. The neuroendocrine response to oral citalopram and l-5HTP was measured primarily as the prolactin and cortisol area under the response curve (or AUC). The study comprised 2 studies: Study 1. A double blind, randomised dose ranging study was conducted with l-5HTP (50-200 mg) to explore the prolactin and/or cortisol dose response and select a dose that provided a threshold neuroendocrine response. Study 2. A randomized comparison of citalopram 20 vs 40 mg was used to assess the effect of these doses on prolactin and cortisol. Based on the results of the dose response assessments with l-5HTP and cortisol, 200 mg l-5HTP was subsequently used in Study 2 to explore the augmentation of the neuroendocrine response to 20 mg citalopram. Citalopram, but not l-5HTP, increased prolactin AUC(0-3h) while 5HTP and citalopram increased cortisol AUC(0-3h). A 200 mg dose of l-5HTP significantly augmented the prolactin and cortisol response AUC(0-3h) to 20mg oral citalopram. The results of the study suggest that an augmented neuroendocrine challenge may be a suitable marker to demonstrate increased 5-HT-mediated responses when exploring novel agents as improved SSRIs.
Posted by torrid2 on January 18, 2012, at 17:36:07
In reply to Anyone had success with SSRI combined with 5htp?, posted by mogger on January 18, 2012, at 14:35:22
5htp gave me a heart arythmia. I was desperate and kepy uping the dose so it likely was dose related. I SAMe works great for me but 5htp did nothing/
Posted by mogger on January 18, 2012, at 17:51:00
In reply to Re: Anyone had success with SSRI combined with 5htp? » mogger, posted by torrid2 on January 18, 2012, at 17:36:07
5htp gave you a heart arythmia with an ssri or by itself? That is great that Sam-e is working for you!
This is the end of the thread.
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