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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by poser938 on January 3, 2012, at 2:46:14
i have been suffering from some severe anhedonia for a while now. it all started when i took mirapex to help with libido. for about a month it helped really well and then all the sudden its effects reversed and left decreased my ability to feel pleasure. after this happened i tried tianeptine and it only made the problem worseafter 10 days. and then i tried ritalin and it made me even worse after 1 dose. my theory is that the my dopamine receptors had been overstimulated by the mirapex, causing a decrease in synthesis/release of dopamine. and further stimulation of my receptors by meds such as ritalin or tianeptine only leads to a decrease in my brains ability to naturally release dopamine.
one med i found to help was cyproheptadine, and i think it was its 5ht2c antagonism that helped me. i read that when that receptor is blocked off, your brain release more dopamine in response to normally pleasurable things and doesnt force your brain to release dopamine like ritalin does. but i became tolerant to a much too high dose of it and my tolerance doesnt seem to be going away (even after a year) so now i have deplin, which i filled earlier and am hoping it might could help me. i let my mom take one earlier and she said she felt "stimulated" like how you feel from an increase in dopamine. i am afraid to try it myself though. i would feel better if i could find more info on how deplin affects the brain, but i really just cant find much inforomation on the internet about...
i hope all this makes sense!
Posted by Phillipa on January 3, 2012, at 10:28:17
In reply to any advice on whether or not deplin could help me, posted by poser938 on January 3, 2012, at 2:46:14
Yes when I took it could find nothing either. Seems the Deplin reps have been posting on babble. In the archieves a few interesting thread on how it works. Jan/P
Posted by poser938 on January 3, 2012, at 12:06:20
In reply to Re: any advice on whether or not deplin could help me » poser938, posted by Phillipa on January 3, 2012, at 10:28:17
thanks, i'll try finding a good post on it.
Posted by mrtook on January 4, 2012, at 11:09:48
In reply to Re: any advice on whether or not deplin could help me, posted by poser938 on January 3, 2012, at 12:06:20
Based on what Deplin is I would be very surprised if you noticed a significant negative effect. If you have the genetic abnormalities Deplin is intended to treat (improper folate metabolism) you will notice an effect most likely a postive one.
However, some people have reported not liking deplin, but the downsides seem to be pretty muted, and there are a number of people here who feel it is their wonder drug. I take it and I feel like I am able to go for longer periods of time without any hiccups, but I don't think it is a dramatic improvement for me. It wouldn't surprise me if I didn't have the genetic difference and thus Deplin is pure placebo to me.
I would suggest going ahead and giving it a shot.
This is the end of the thread.
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