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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by uncouth on December 22, 2011, at 10:23:16
hey all,
there is a good thread on longevity.com (search for uridine) about uridine. A few people including myself are trying it and have reported early and good results with bipolar depression and obsessive thinking. Its too early to say anything, but there are a few studies on uridine showing that it has some promise when taken with DHA fish oil. I am taking 75mg of the triacetyluridine form which supposedly is equivalent to around 500mg regular uridine, along with 1250mg DHA (and 2g EPA but uridine works with DHA).
The deal is that uridine combined with DHA increases phosphatidlycholine synthesis and supports cell membranes, etc. In any event, it got pretty good results in a few studies a few years ago, the most recent study used 18g of triacetyluridine so it's questionable whether 75mg will actually do anything, but so far so good for me. It may have been placebo effect, but I seemed to feel better (at the minimum more grounded less obsessive thinking) after two days. So much so that I considered not starting the low dose SSRI I was supposed to start last night (i started it anyway, strangely this morning woke up feeling a bit more down, go figure SSRIs).
You can get triacetyluridine i think from swansons vitamins or other places. I am using cardiovascular research brand. It's cheap.
I think some of you treatment resistant bipolar 2 depression sufferers and some of you OCD people should definitely do a trial. Post on this thread your experience.
I know we are all used to hearing some supplement or whatever as being the magic bullet but uridine has been looked at by the NIH pretty seriously and it seems very low risk, and the dosages we would be using would be very low.
Anyway, if anyone has any experience to add, please share. The combo is also being looked at for alzheimers by danone in the "souvanaid" medical food.
Uncouth
Posted by Phillipa on December 22, 2011, at 10:33:17
In reply to Uridine (Triacetyluridine) + DHA anyone?, posted by uncouth on December 22, 2011, at 10:23:16
Uridine haven't heard of it? Uncouth any links you like on this supplement? I also was told by old pdoc and tape she gave me that NAC with deplin was being studied for Alzheimers . Phillipa
Posted by iforgotmypassword on December 27, 2011, at 20:33:34
In reply to Re: Uridine (Triacetyluridine) + DHA anyone? » uncouth, posted by Phillipa on December 22, 2011, at 10:33:17
it would seem to mean using several grammes of spirulina to get whatever form of uridine that is in it, if the type is even comparably useful, at the seemingly right doses.
there does not seem to be any simple or cheap means of getting uridine monophosphate or triacetyluridine , I am somewhat keen to try a dietary source if it is worthwhile. To take likely with vegan dha and leftover choline considerate
seems at all sensible/meaningful to go this route or just a waste?
Posted by iforgotmypassword on December 27, 2011, at 20:36:15
In reply to Re: Uridine (Triacetyluridine) + DHA anyone? » uncouth, posted by Phillipa on December 22, 2011, at 10:33:17
Posted by Mrhappy on January 4, 2012, at 0:51:23
In reply to spriulina instead as a source?, posted by iforgotmypassword on December 27, 2011, at 20:33:34
Hi,
I'm the original poster of the thread on Longecity.
Google 'ecological formulas uridine' without quote marks and you'll find a wealth of both TAU and UMP suppliers online. They are both inexpensive. Bulk UMP powder is available from a few sources.
For vegetarians - flaxseed oil is a good source of ALA, which will be converted into DHA and EPA.
Additionally, you will require a good multivitamin and / or additional supplements to provide sufficient quantities of B6,9,12 and a mixed vitamin E / tocopherol.
This is the end of the thread.
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