![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by BrainDamage on November 8, 2011, at 3:29:53
http://uk.news.yahoo.com/astrazeneca-targacept-drug-misses-goal-study-073218634.html
Posted by SLS on November 8, 2011, at 5:14:13
In reply to Bad News on the Doorstep-Depression drug fails, posted by BrainDamage on November 8, 2011, at 3:29:53
> http://uk.news.yahoo.com/astrazeneca-targacept-drug-misses-goal-study-073218634.html
"TC-5214 -- viewed by analysts as a high-risk, high-reward project -- is designed to work in a novel way by modulating neuronal nicotinic receptors in the brain. Over-stimulation of these receptors is thought to be associated with depression."
The key word here is "associated". This over-stimulation could be a consequence rather than a cause of depression. This may not have been ascertained prior to designing the drug, making its development very risky financially. Let's hope that this failure doesn't make the drug company shy to test novel drugs in the future.
- Scott
Posted by ed_uk2010 on November 8, 2011, at 9:56:48
In reply to Re: Bad News on the Doorstep-Depression drug fails, posted by SLS on November 8, 2011, at 5:14:13
> Let's hope that this failure doesn't make the drug company shy to test novel drugs in the future.
Like many large pharmaceutical companies, AstraZeneca is far too dependent on its current blockbusters, many of which are losing patent protection in key markets. They don't have enough new drugs in the pipeline to make up for this. Just as an example, generic esomeprazole has recently been launched in the UK and sales of Nexium are now much lower. They had better get testing!!
Posted by Phillipa on November 8, 2011, at 9:56:52
In reply to Re: Bad News on the Doorstep-Depression drug fails, posted by SLS on November 8, 2011, at 5:14:13
I heard that the drug companies were in a lot of financial trouble in general with the generics. No idea of true or not. Phillipa
Posted by ed_uk2010 on November 8, 2011, at 10:03:27
In reply to Re: Bad News on the Doorstep-Depression drug fails, posted by Phillipa on November 8, 2011, at 9:56:52
> I heard that the drug companies were in a lot of financial trouble in general with the generics. No idea of true or not.
It is true. Patents on many major branded medicines are expiring and generics are being launched. Rightly so, the branded manufacturers cannot make $$$$$ from their old products forever. They need to launch more new medicines... but they don't have enough molecules in the pipeline.
Posted by Phillipa on November 8, 2011, at 18:48:59
In reply to Re: Bad News on the Doorstep-Depression drug fails » Phillipa, posted by ed_uk2010 on November 8, 2011, at 10:03:27
Ed so with all the red tape and testing what's the answer? Really none? Love PJxx
Posted by ed_uk2010 on November 9, 2011, at 5:44:51
In reply to Re: Bad News on the Doorstep-Depression drug fails » ed_uk2010, posted by Phillipa on November 8, 2011, at 18:48:59
> Ed so with all the red tape and testing what's the answer? Really none? Love PJxx
I guess more research into new drugs needs to be done. No easy answers.
Posted by Chairman_MAO on November 10, 2011, at 6:03:52
In reply to Bad News on the Doorstep-Depression drug fails, posted by BrainDamage on November 8, 2011, at 3:29:53
> http://uk.news.yahoo.com/astrazeneca-targacept-drug-misses-goal-study-073218634.html
I would not have bet on this working.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.