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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by iforgotmypassword on August 9, 2011, at 11:00:52
wat the? (article below.)
They say "female sex steroids" and I can't get the full text to figure out what they are putting under that definition. Birth control pills usually only have ethinyl estradiol (which has a lot of scary effects wrt the liver, but i thought mostly related to clots forming) and any one of a bunch of different progestins that are common.
I take plain estradiol sublingually (4mg), and cyproterone acetate at 150mg, which is a very high dose as I am not taking it for birth control but rather as an anti-androgen in a transgender HRT regimen. Now I am worried taking selegiline will require dietary restrictions; is this true and is there any affordable away around this?
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The article:
Dose linearity study of selegiline pharmacokinetics after oral administration: evidence for strong drug interaction with female sex steroids
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.1999.00891.x/abstract
Posted by larryhoover on August 9, 2011, at 14:33:12
In reply to selegiline + birth control = accidental megadose?, posted by iforgotmypassword on August 9, 2011, at 11:00:52
> wat the? (article below.)
>
> They say "female sex steroids" and I can't get the full text to figure out what they are putting under that definition. Birth control pills usually only have ethinyl estradiol (which has a lot of scary effects wrt the liver, but i thought mostly related to clots forming) and any one of a bunch of different progestins that are common.
>
> I take plain estradiol sublingually (4mg), and cyproterone acetate at 150mg, which is a very high dose as I am not taking it for birth control but rather as an anti-androgen in a transgender HRT regimen. Now I am worried taking selegiline will require dietary restrictions; is this true and is there any affordable away around this?
>
> -------
>
> The article:
>
> Dose linearity study of selegiline pharmacokinetics after oral administration: evidence for strong drug interaction with female sex steroids
>
> http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.1999.00891.x/abstractWow! You'd think somebody would have noticed this profound effect before this.
Using the link you provided, I clicked on the .pdf full text article, and it loaded for me.
The drugs you're using are not identical to any of those identified in this very small study. I don't have any way of knowing how generalizable these results might be. And I don't know where you could obtain the answer.
I wish I could help, but I'm sorry that I can't.
Lar
Posted by iforgotmypassword on August 19, 2011, at 14:03:25
In reply to Re: selegiline + birth control = accidental megadose? » iforgotmypassword, posted by larryhoover on August 9, 2011, at 14:33:12
Just had a cluster of things to try to articulate and am not doing so well in the fluency dept.; but thank you, just knowing I have the full text to look at later and bring to my doctor is very helpful. Its just the type of thing I miss when I can't concentrate, I thought it was totally locked.
In the immediate I am going to try to start a post about my getting a homocysteine test tomorrow morning and starting TMG shortly after. Certain things seem to suggest this may be a worthwhile and maybe even an essential focus for me. (i.e. am vegan, have tardive sx, fatigue, serious cognitive issues, incomplete and sometimes totally intolerable response to stimulants)
This is the end of the thread.
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