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Dr. Bob is Robert Hsiung, MD,
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Posted by Phillipa on May 5, 2011, at 23:26:01
Conflicting report. First it was thought that inflammation may increase depression now finding that ASA or Non-steriodal antiinflammatories can or may decrease effects of SSRI's Phillipa
http://www.healthcentral.com/depression/c/84292/137571/antidepressant
Posted by desolationrower on May 6, 2011, at 4:51:36
In reply to Can ASA or NSAIDS Decrease Your SSRI?, posted by Phillipa on May 5, 2011, at 23:26:01
here is a link to the abstract: http://www.pnas.org/content/early/2011/04/20/1104836108.short
Obviously, the STAR*D data can be seen the other way, that if you were taking an NSAID and still in the trial (still depressed), that can be seen as another medication failure (the NSAID didn't cause remission). and the more med failures, the lower the response rate.
It does seem plausible: the rodent data is interesting. I would guess there might be an issue of the NSAID reducing arachadonic acid metabolites which are involved in learning. So basically you can't ahve enough of a stress for your brain to say, 'hey this is IMPORTANT' and rewire itself to include the new, non-depressed memory. AA has shown benefits for senility, for example.
iti reminds me of the benefits yohimbe show for relearning (there is a specific term i'm not rememberig, lol) anxiogenic memory, even though on its own, it increases panic.
-d/r
Posted by Phillipa on May 6, 2011, at 19:55:23
In reply to Re: Can ASA or NSAIDS Decrease Your SSRI?, posted by desolationrower on May 6, 2011, at 4:51:36
Thanks d/r you are so very helpful. Phillipa
This is the end of the thread.
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