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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Hombre on January 23, 2011, at 18:59:49
I went into one of the local drug stores to pick up something for heartburn (too much booze a few days ago). Probably due to the fact that my command of the local language is not so good, I ended up with something really strange:
Ingredients:
Scopolamine-N-butylbromide 2.0mg
Dicyclomine Hydrochloride 2.0mg
Chlordiazepoxide Hydrochloride 5.0mg
Sodium Copper Chlorophylin 5.0mg
Hydroxide Aluminum Magnesium Co-Dried Gel 350.0mg
Magnesium Oxide 40.0mg
Synthetic Aluminum Silicate 60.0mgAs far as I can tell this medicine has antispasmodic, antimuscarinic (is that a word?), anticholinergic, sedative/anxiolytic, antacid, and possibly antidepressant qualities. I took 2 like I was told, I suppose my heartburn felt a little better. I don't know if I felt any benzo-type activity from the chlordiazepoxide (Librium). I actually felt kind of vulnerable when I went to bed last night, if that makes any sense. I did wake up early and I feel pretty good after breakfast.
This is one hell of an OTC medicine. I think it's more for a nauseous hangover rather than heartburn, but I guess since I said I drank too much the guy thought I was feeling really low.
Anyway, just thought I'd share this with y'all since you might have more insight into this interesting combination of chemicals. I don't plan to take it recreationally or as a potential antidepressant, although I might take one more dose in the light of day just to see what it really does to my mood.
Posted by Phillipa on January 24, 2011, at 11:09:46
In reply to Antispasmodic/Benzo Stomach Med: What is this?, posted by Hombre on January 23, 2011, at 18:59:49
Scolpalamine I know is for seasickness and dizzyness from it. The librium you know, the magnesium probably calming also. Sounds like your're in Mexico or an Island. Phillipa
Posted by Hombre on January 25, 2011, at 6:52:33
In reply to Re: Antispasmodic/Benzo Stomach Med: What is this? » Hombre, posted by Phillipa on January 24, 2011, at 11:09:46
What's interesting is that there has been at least one study asserting that scopolamine is an antidepressant.
I took one more dose in the morning...I think it made me sleepy later on in the day and even the next morning. No fun wanting to sleep all day, and the heartburn seems to be gone, so into the medicine cabinet for this stuff.
Posted by Phillipa on January 25, 2011, at 18:43:10
In reply to Re: Antispasmodic/Benzo Stomach Med: What is this?, posted by Hombre on January 25, 2011, at 6:52:33
An ad? Phillipa
Posted by Hombre on January 25, 2011, at 19:21:08
In reply to Re: Antispasmodic/Benzo Stomach Med: What is this?, posted by Hombre on January 25, 2011, at 6:52:33
Scopolamine can act as an antidepressant:
http://www.ncbi.nlm.nih.gov/pubmed/20074703
Biol Psychiatry. 2010 Mar 1;67(5):432-8. Epub 2010 Jan 15.
Replication of scopolamine's antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial.Drevets WC, Furey ML.
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.
AbstractBACKGROUND: We previously reported that intravenous (IV) scopolamine administration produced rapid and robust antidepressant effects in a sample consisting of both unipolar and bipolar depressives. The present study aimed to replicate this finding in an independent sample limited to unipolar depressives.
METHODS: Outpatients with major depressive disorder (MDD; n = 23; 22 were included in analyses) participated in a double-blind, placebo-controlled, crossover trial. Subjects were randomized into either a P/S or S/P sequence (P = block of three placebo sessions; S = block of three scopolamine sessions; [4.0 microg/kg IV]). Sessions occurred 3 to 5 days apart, such that time spent in each block lasted 1.5 to 2 weeks and the interval between blocks was 3 to 5 days. The Montgomery-Asberg Depression Rating Scale (MADRS) served as the primary outcome measure.
RESULTS: Following the initial block, the group receiving scopolamine first (S/P) showed a 32% reduction in MADRS scores (p < .001), which exceeded the corresponding change of 6.5% under placebo (P/S; p = .009), confirming the a-priori hypothesis. Improvement was significant at the first evaluation that followed scopolamine administration (p = .011). In Block 2, the P/S group showed a 53% reduction in MADRS scores (p = .001) following scopolamine versus placebo, whereas the reduction seen in S/P subjects who received scopolamine during Block 1 persisted as they received placebo during Block 2. Scopolamine induced drowsiness, blurred vision, dry mouth, light-headedness, and reduced blood pressure, which were sufficiently well tolerated that no subject dropped out because of side effects.
CONCLUSIONS: These results replicate previous finding that scopolamine produces a rapid and robust antidepressant response.
And it is apparently rapid in in its action:http://hubpages.com/hub/Scopolamine-ARapidRespondingAntidepressant
Posted by Hombre on January 25, 2011, at 19:22:34
In reply to Scopolamine as a Rapid Acting Antidepressant, posted by Hombre on January 25, 2011, at 19:21:08
Oops. Last two links are virtually identical.
Posted by Phillipa on January 25, 2011, at 21:03:02
In reply to Re: Scopolamine as a Rapid Acting Antidepressant, posted by Hombre on January 25, 2011, at 19:22:34
Thanks wonder how the people feel that use it on ships to prevent seasickness? Phillipa
This is the end of the thread.
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