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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by vasco378 on December 20, 2010, at 10:02:10
Hi all, I am a newbie to this forum and have a burning question.
I take tranylcypromine (20mg/day), and am considering adding reboxetine or atomoxetine. This is because these two drugs are potent noradrenaline reuptake inhibitors which may provide a strong protective effect against tyramine induced hypertensive crsis. Well at least this research found this to be the case:
http://www.ncbi.nlm.nih.gov/pubmed/7931221
In fact the "tyramine pressor response test" is a test often used to test the ability of a drug to block noradrenaline re-uptake. The more able a drug is in preventing tyramine induced blood pressure increases the stronger the noradrenaline re-uptake it has.
Does anyone have experience of combining tranylcypromine with reboxetine, atomoxetine or other noradraneline re-uptake inhibitirs? Did it seem to help prevent hypertensive crisis or blood pressure rises? Did it affect the efficacy of the tranylcypromine?
Any insights would be awesome...
Posted by Conundrum on December 20, 2010, at 11:12:22
In reply to Tranylcypromine (Parnate) and reboxetine, posted by vasco378 on December 20, 2010, at 10:02:10
Hi,
Scott is taking Nardil with the adrenergic TCA, nortriptyline. YOu might babble mail him if you have questions. I'd would research carefully which norepinephrine reuptake inhibitor you want to take. I've read that strattera can make depression worse. Reboxetine, might be a better, bet, but I would research that drug as well. I don't know a whole lot about it.> Hi all, I am a newbie to this forum and have a burning question.
>
> I take tranylcypromine (20mg/day), and am considering adding reboxetine or atomoxetine. This is because these two drugs are potent noradrenaline reuptake inhibitors which may provide a strong protective effect against tyramine induced hypertensive crsis. Well at least this research found this to be the case:
>
> http://www.ncbi.nlm.nih.gov/pubmed/7931221
>
> In fact the "tyramine pressor response test" is a test often used to test the ability of a drug to block noradrenaline re-uptake. The more able a drug is in preventing tyramine induced blood pressure increases the stronger the noradrenaline re-uptake it has.
>
> Does anyone have experience of combining tranylcypromine with reboxetine, atomoxetine or other noradraneline re-uptake inhibitirs? Did it seem to help prevent hypertensive crisis or blood pressure rises? Did it affect the efficacy of the tranylcypromine?
>
> Any insights would be awesome...
>
>
Posted by Vasco378 on December 20, 2010, at 15:32:35
In reply to Re: Tranylcypromine (Parnate) and reboxetine » vasco378, posted by Conundrum on December 20, 2010, at 11:12:22
Hi, thanks. Will contact him. The possibility of hypertensive crisis really scares me even though I am told its rare. Logically MAOI plus NRI makes real sense, just don't know why it hasn't been tried more often...
Posted by Maxime on December 20, 2010, at 15:49:01
In reply to Tranylcypromine (Parnate) and reboxetine, posted by vasco378 on December 20, 2010, at 10:02:10
Welcome to Psycho Babble!
I take Parnate myself. I was taking it with Nortriptyline but I was gaining a lot of weight with it so I stopped taking it (the Nortrip). I am really not doing well AT ALL and I don't know if it is stopping the Nortrip or if the Parnate is pooping out on me. I take 100 mg of Parnate.
I don't know anything about Roboxetine so I can't give you advice there.
I hope you get the answer you are looking for here. The board is slow these for various reasons so don't get discouraged if someone doesn't answer your specific question right away. Hopefully Scott (SLS) will see your post and he will be able to help.
Posted by emmanuel98 on December 20, 2010, at 19:59:05
In reply to Tranylcypromine (Parnate) and reboxetine, posted by vasco378 on December 20, 2010, at 10:02:10
I don't know the answer to your question, but I can tell you that hypertensive crises are pretty rare unless you really push things with the diet. Except for hypertensive crises, parnate really doesn't effect your blood pressure much, except for occasional low BP when getting out of bed. (orthostatic hypotension)
This is the end of the thread.
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