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Dr. Bob is Robert Hsiung, MD,
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Posted by rovers95 on July 14, 2010, at 12:44:32
Do the anti-cholinergic side effects of drugs (particulary tricyclics) contribute to their efficacy?
I found a paper suggesting they did (but know i cant find it!!), but do these effects dissipate with time?
cheers
rover
Posted by SLS on July 14, 2010, at 12:57:27
In reply to anti-cholinergic AD's = therapeautic efficacy, posted by rovers95 on July 14, 2010, at 12:44:32
> Do the anti-cholinergic side effects of drugs (particulary tricyclics) contribute to their efficacy?
> I found a paper suggesting they did (but know i cant find it!!), but do these effects dissipate with time?Look for papers involving scopolamine and depression.
- Scott
Posted by rovers95 on July 14, 2010, at 17:40:14
In reply to Re: anti-cholinergic AD's = therapeautic efficacy, posted by SLS on July 14, 2010, at 12:57:27
> > Do the anti-cholinergic side effects of drugs (particulary tricyclics) contribute to their efficacy?
>
> > I found a paper suggesting they did (but know i cant find it!!), but do these effects dissipate with time?
>
> Look for papers involving scopolamine and depression.
>
>
> - ScottI tried scopolamine, it worked but it was weird and withdrawal messed me up.
What i've wondered is whether the long term AD efficacy of tricyclics (and maybe other AD's) could be partly attributed to anti-cholinergic effects (as opposed to just increased moanamine's....which in turn could also create a predominance over acetylcholine).
thanks
rover
Posted by linkadge on July 15, 2010, at 14:11:38
In reply to Re: anti-cholinergic AD's = therapeautic efficacy » SLS, posted by rovers95 on July 14, 2010, at 17:40:14
Monoamine reuptake inhibitors have some downstream anticholinergic effects in their own right. NRI's especially produce anticholinergic like effects even when the molecule has no cholinergic affinity. M1 antagonists especially, appear to have antidepressant effects. Mice lacking m1 receptors are particularly responsive to amphetamines due to increased cortical DA release.
Linkadge
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