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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by sowhysosad on April 19, 2010, at 12:11:49
Does anyone know how long it takes for the brain to break down neurotransmitters and, more specifically, dopamine? Or could you point me towards any research?
I want to reduce my daily dosage of L-Tyrosine as I think 1.5g is way too high for me, but I'm wondering how few doses I could take to maintain the dopamine boost through the day. (Shame I can only get 500mg capsules - it's a pretty hefty dose!)
Thanks!
Posted by SLS on April 19, 2010, at 12:22:07
In reply to How long for brain to break down neurotransmitters, posted by sowhysosad on April 19, 2010, at 12:11:49
> Does anyone know how long it takes for the brain to break down neurotransmitters and, more specifically, dopamine? Or could you point me towards any research?
>
> I want to reduce my daily dosage of L-Tyrosine as I think 1.5g is way too high for me, but I'm wondering how few doses I could take to maintain the dopamine boost through the day. (Shame I can only get 500mg capsules - it's a pretty hefty dose!)
>
> Thanks!
I don't know how to answer your question, but you might look for literature concerning neurotransmitter turnover.
- Scott
Posted by Phillipa on April 19, 2010, at 12:30:20
In reply to Re: How long for brain to break down neurotransmitters » sowhysosad, posted by SLS on April 19, 2010, at 12:22:07
How does a brain break down neurotransmitters? I thought they were just the chemicals the ones we know of in the brain and that usually we boost them. Why break them down? I just don't understand Thands Phillipa
Posted by sowhysosad on April 19, 2010, at 12:37:34
In reply to Re: How long for brain to break down neurotransmitters » sowhysosad, posted by SLS on April 19, 2010, at 12:22:07
> > Does anyone know how long it takes for the brain to break down neurotransmitters and, more specifically, dopamine? Or could you point me towards any research?
> >
> > I want to reduce my daily dosage of L-Tyrosine as I think 1.5g is way too high for me, but I'm wondering how few doses I could take to maintain the dopamine boost through the day. (Shame I can only get 500mg capsules - it's a pretty hefty dose!)
> >
> > Thanks!
>
>
> I don't know how to answer your question, but you might look for literature concerning neurotransmitter turnover.
>
>
> - ScottThanks Scott!
I did Google extensively before posting but I'll search again using the correct terminology!
Posted by SLS on April 19, 2010, at 12:39:03
In reply to Re: How long for brain to break down neurotransmitters » SLS, posted by Phillipa on April 19, 2010, at 12:30:20
> How does a brain break down neurotransmitters? I thought they were just the chemicals the ones we know of in the brain and that usually we boost them. Why break them down? I just don't understand Thands Phillipa
The continuous synthesis and break-down of neurotransmitters provides for a dynamic regulation of their concentrations. MAO and COMT help to prevent neurotransmitter excess through catabolism.
- Scott
Posted by SLS on April 19, 2010, at 12:40:23
In reply to Re: How long for brain to break down neurotransmitters, posted by sowhysosad on April 19, 2010, at 12:37:34
> > > Does anyone know how long it takes for the brain to break down neurotransmitters and, more specifically, dopamine? Or could you point me towards any research?
> > >
> > > I want to reduce my daily dosage of L-Tyrosine as I think 1.5g is way too high for me, but I'm wondering how few doses I could take to maintain the dopamine boost through the day. (Shame I can only get 500mg capsules - it's a pretty hefty dose!)
> > >
> > > Thanks!
> >
> >
> > I don't know how to answer your question, but you might look for literature concerning neurotransmitter turnover.
> >
> >
> > - Scott
>
> Thanks Scott!
>
> I did Google extensively before posting but I'll search again using the correct terminology!
Please post your results. I will be very interested in what you find.Good luck!
- Scott
Posted by bleauberry on April 19, 2010, at 17:19:33
In reply to How long for brain to break down neurotransmitters, posted by sowhysosad on April 19, 2010, at 12:11:49
I'm fairly confident this is a genetic thing. It will vary from person to person depending on the unique genes they were born with, genetic mutations that occured after birth, and genetic insults from the impacts of disease and environment.
As for the tyrosine dosage, that is very easy to customize. At the health food store or Whole Foods Market, get a bag of "OO" empty gel caps. Empty the powder of the tyrosine capsule onto a flat plate. The next step is exactly what cocaine users do. Don't do it with cocaine. Do it with tyrosine powder. That is, with a single edged razor blade draw the powder into a line. Shape it so that it is about the same width and height the length of the line. Then you can cut it into whatever pieces you want. For example, a 500mg line divided into four would be 125mg each. Then take the portion of the line you divided, use the razor blade to push it onto a knife, and then dump it into the empty gel cap. You now have your own custom 125mg capsule. Or whatever other size you might want.
Sometimes it can make it easier to mix the powder with something else, such as rice flour. It depends on how hard it is to manipulate whatever particular powder you are dealing with. Some are fluffy and easy, others are granular and more finnicky. Flour mixed in can help, if needed.
There is some error in this method since it is all visual. But the eyes are pretty accurate. You can tell if one portion is more than another. The doses will be very close, with any differences not being significant enough to notice.
Long story made short, just because the tyrosine doses are sold in 500mg does not at all mean you are limited to only that choice. You can create whatever size dose you want in about 3 minutes.
> Does anyone know how long it takes for the brain to break down neurotransmitters and, more specifically, dopamine? Or could you point me towards any research?
>
> I want to reduce my daily dosage of L-Tyrosine as I think 1.5g is way too high for me, but I'm wondering how few doses I could take to maintain the dopamine boost through the day. (Shame I can only get 500mg capsules - it's a pretty hefty dose!)
>
> Thanks!
Posted by sowhysosad on April 19, 2010, at 17:33:24
In reply to Re: How long for brain to break down neurotransmitters, posted by bleauberry on April 19, 2010, at 17:19:33
> I'm fairly confident this is a genetic thing. It will vary from person to person depending on the unique genes they were born with, genetic mutations that occured after birth, and genetic insults from the impacts of disease and environment.
Yeah, I'm sure you're right. Apparently there's some evidence that some people have a gene that causes faster dopamine turnover.
> As for the tyrosine dosage, that is very easy to customize. At the health food store or Whole Foods Market, get a bag of "OO" empty gel caps. Empty the powder of the tyrosine capsule onto a flat plate. The next step is exactly what cocaine users do. Don't do it with cocaine. Do it with tyrosine powder. That is, with a single edged razor blade draw the powder into a line. Shape it so that it is about the same width and height the length of the line. Then you can cut it into whatever pieces you want. For example, a 500mg line divided into four would be 125mg each. Then take the portion of the line you divided, use the razor blade to push it onto a knife, and then dump it into the empty gel cap. You now have your own custom 125mg capsule. Or whatever other size you might want.
>
> Sometimes it can make it easier to mix the powder with something else, such as rice flour. It depends on how hard it is to manipulate whatever particular powder you are dealing with. Some are fluffy and easy, others are granular and more finnicky. Flour mixed in can help, if needed.
>
> There is some error in this method since it is all visual. But the eyes are pretty accurate. You can tell if one portion is more than another. The doses will be very close, with any differences not being significant enough to notice.
>
> Long story made short, just because the tyrosine doses are sold in 500mg does not at all mean you are limited to only that choice. You can create whatever size dose you want in about 3 minutes.Great tip - thanks. It would also make the Tyrosine go a lot further than half-emptying the capsules!
My only problem may be finding empty gel caps in the UK. So far the only option I've found would be to buy paracetamol caps and empty them, but it might be a bit pricey!
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