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Dr. Bob is Robert Hsiung, MD,
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Posted by Rosy Crucifiction on March 3, 2010, at 11:57:08
I'll look for the MAOI Betahistine thread. There is a theory that betahistine is useful for atypical depression because, like MAOIs, it increases all neurotransmitters through antagonism of the h3 histamine receptor. The effects on the other NTs may be why MAOIs are effective in some people for whom tricyclics are not.
Betahistine appears to be pretty safe, although I wouln't take it with an MAOI for the above reason. Nausea is the most common side effect. Dosages for cognitive reasons are higher - in the range of 48-200 mg daily.
Here's an interesting overview of H3:
http://molinterv.aspetjournals.org/content/6/2/77.fullTreatment methods employing histamine h3 receptor antagonists, including betahistine (a patent application with some info on dosing):
http://www.freshpatents.com/-dt20091203ptan20090298892.phpObecure Is Granted Methods And Composition Patents Covering Adjunctive Use Of Betahistine To Mitigate Weight Gain Associated With Olanzapine
http://www.medicalnewstoday.com/articles/180134.php
Posted by Phillipa on March 3, 2010, at 12:33:50
In reply to Re: betahistine for cognitive dysfunction (safety, posted by Rosy Crucifiction on March 3, 2010, at 11:57:08
This H3 seems to cover and do almost everything. Very complicated to me. Phillipa
Posted by CrAzYmEd on March 3, 2010, at 12:57:05
In reply to Re: betahistine for cognitive dysfunction (safety » Rosy Crucifiction, posted by Phillipa on March 3, 2010, at 12:33:50
Yes, betahistine sparkeled my intrest lately. I hope to try it soon.
This is the end of the thread.
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