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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by tiopenster on October 23, 2009, at 10:14:51
There's a new Anti-depressant out in the EU and Canada called Valdoxan. I need help knowing from you experts out there more about it's mechanism of action. I don't understand the agonist/antagonist thing.
Anytime I take something that affects Serotonin, I respond with increased anxiety, which is a problem because I'm trying to treat GAD. I've tried all the SSRI's. Since this has a unique mechanism of action, I'm having a hard time figuring out how this Valdoxan works and how I would respond.
Valdoxan.com says that Valdoxan is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist. Valdoxan increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin.
It says that it's a 5HT2c antagonist but it doesn't affect extracellular serotonin. That seems like a contradiction. If I don't respond well to things that affect serotonin, will I react badly to this?
I'm assuming here, of course, that I can buy this drug from Canada.
Posted by Phillipa on October 23, 2009, at 12:42:50
In reply to New Antidepressant for Anxiety? - Valdoxan, posted by tiopenster on October 23, 2009, at 10:14:51
I didn't know it was in Canada. I also don't understand agonist vs antagonist although as been explained to me. The sites I read say helps withs circadiam rhythms so helps with sleep and no sexual effects. But then compared it to paxil and zoloft. I also get anxiety with any ad. Great question. Phillipa
Posted by manic 666 on October 23, 2009, at 13:09:16
In reply to New Antidepressant for Anxiety? - Valdoxan, posted by tiopenster on October 23, 2009, at 10:14:51
that med is agomelatine, just a different name.
Posted by Meltingpot on October 24, 2009, at 4:56:29
In reply to Re: New Antidepressant for Anxiety? - Valdoxan » tiopenster, posted by Phillipa on October 23, 2009, at 12:42:50
Hi Phillipa,
I think that Agonists Stimulate receptors and antagonists block them.
Denise
Posted by Jay_Bravest_Face on October 24, 2009, at 20:00:51
In reply to New Antidepressant for Anxiety? - Valdoxan, posted by tiopenster on October 23, 2009, at 10:14:51
This is the end of the thread.
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