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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by rovers95 on October 21, 2009, at 13:17:48
Hey, does anyone know about the effects of long term scolopamine (or any anti-cholinergic med) on cholinergic neurons, i've read loads of stuff that it actually increases the sensitivity of the brain to choline and i really think thats happened to me, is this effect reversible and how?!
thanks
rover
Posted by linkadge on October 21, 2009, at 14:50:06
In reply to scopolamine has messed me up?!!, posted by rovers95 on October 21, 2009, at 13:17:48
possibly. I would try something like alpha lipoic acid. Vitamin C has some effects on regulating muscarinic receptor expression.
Posted by Phillipa on October 21, 2009, at 16:12:53
In reply to Re: scopolamine has messed me up?!!, posted by linkadge on October 21, 2009, at 14:50:06
Isn't that the patch you wear behind your ear if on a ship and get seasick. I'm sorry. Love Phillipa
Posted by Bob on October 22, 2009, at 0:31:33
In reply to scopolamine has messed me up?!!, posted by rovers95 on October 21, 2009, at 13:17:48
> Hey, does anyone know about the effects of long term scolopamine (or any anti-cholinergic med) on cholinergic neurons, i've read loads of stuff that it actually increases the sensitivity of the brain to choline and i really think thats happened to me, is this effect reversible and how?!
>
> thanks
>
> roverI don't know the answer to your question, but I would like to say something about Scopolamine. A few years back I went on a cruise and used the drug and it screwed me up too. When I came home I actually went through a withdrawal where I was dizzy, depressed, and nauseous for days. My fiance also went through a withdrawal which caused her to vomit. I won't be taking scopolamine any longer, but I'm sensitive to a lot of meds anyway.
Posted by rovers95 on October 22, 2009, at 4:54:55
In reply to Re: scopolamine has messed me up?!! » linkadge, posted by Phillipa on October 21, 2009, at 16:12:53
Yeah but there's a bit of evidence suggesting its good on depression and for giving up smoking, and I used it for both with reasonable success.
However, in the long term I think it does more harm than good!
But, I found some old mirtazipine lying around last night, slept like a baby and feel quite good 2day!
Thanks
Rover
Posted by rovers95 on October 22, 2009, at 5:04:46
In reply to Re: scopolamine has messed me up?!!, posted by linkadge on October 21, 2009, at 14:50:06
> possibly. I would try something like alpha lipoic acid. Vitamin C has some effects on regulating muscarinic receptor expression.
Thanks pal, I'm gonna look into that-do u reckon If I took a parkinsons anti-cholinergic it would cause similar upregulation?
Cheers
Rover
Posted by rovers95 on October 22, 2009, at 5:11:03
In reply to Re: scopolamine has messed me up?!!, posted by Bob on October 22, 2009, at 0:31:33
> > Hey, does anyone know about the effects of long term scolopamine (or any anti-cholinergic med) on cholinergic neurons, i've read loads of stuff that it actually increases the sensitivity of the brain to choline and i really think thats happened to me, is this effect reversible and how?!
> >
> > thanks
> >
> > rover
>
> I don't know the answer to your question, but I would like to say something about Scopolamine. A few years back I went on a cruise and used the drug and it screwed me up too. When I came home I actually went through a withdrawal where I was dizzy, depressed, and nauseous for days. My fiance also went through a withdrawal which caused her to vomit. I won't be taking scopolamine any longer, but I'm sensitive to a lot of meds anyway.
>
>Yeah, I've had similar effects....but with more anxiety and insomnia, mine has been 10 days...although I think taking amisulpride straight after did me no favours either!
Cheers
Rover
Posted by linkadge on October 22, 2009, at 16:49:25
In reply to Re: scopolamine has messed me up?!! » linkadge, posted by rovers95 on October 22, 2009, at 5:04:46
You know, I'm not really concerned with cholinergic upregulation because most antidepressants produce a cholinergic upregulation. This is why anticholinergics like benadry can help with AD withdrawl because they reduce cholinergic rebound.
On the other hand, I would not (personally) use scopolamine long term for a depressive disorder. There is evedence of cholinergic dysregulation in depression but this is thought to be a downstream adaptation to...i dunno....second messenger dysregulation, g-protein something r uther.
There is also evedence that long term anticholinergic administration may actually worsen dyskinesia.I use scopolamine periodically when I am in a hypercholinergic state secondary to stress, sensory overload, overwork etc. It seems to quickly put me into a good zone where I can then
use other supplements to reregulate things.I sometimes use scopolamine in combination with magnesium/vitamin c. This combination seems to help me reset fast, and I don't get much withdrawl.
Linkadge
Posted by Bob on October 22, 2009, at 20:31:45
In reply to Re: scopolamine has messed me up?!!, posted by linkadge on October 22, 2009, at 16:49:25
Posted by Bob on October 22, 2009, at 20:32:59
In reply to Re: scopolamine has messed me up?!!, posted by linkadge on October 22, 2009, at 16:49:25
> You know, I'm not really concerned with cholinergic upregulation because most antidepressants produce a cholinergic upregulation. This is why anticholinergics like benadry can help with AD withdrawl because they reduce cholinergic rebound.
>
> On the other hand, I would not (personally) use scopolamine long term for a depressive disorder. There is evedence of cholinergic dysregulation in depression but this is thought to be a downstream adaptation to...i dunno....second messenger dysregulation, g-protein something r uther.
> There is also evedence that long term anticholinergic administration may actually worsen dyskinesia.
>
> I use scopolamine periodically when I am in a hypercholinergic state secondary to stress, sensory overload, overwork etc. It seems to quickly put me into a good zone where I can then
> use other supplements to reregulate things.
>
> I sometimes use scopolamine in combination with magnesium/vitamin c. This combination seems to help me reset fast, and I don't get much withdrawl.
>
> Linkadge
>
>Do you take the scopolamine in patch form?
Posted by linkadge on October 23, 2009, at 16:36:41
In reply to Re: scopolamine has messed me up?!! » linkadge, posted by Bob on October 22, 2009, at 20:32:59
yes
This is the end of the thread.
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