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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by uncouth on October 2, 2009, at 20:59:21
Hi,
I've got a fairly bad case of ED and low sex interest. It's especially curious because i've been on 600mg of bupropion for almost two months. I'm also on Agomelatine, and went OFF of Luvox, and tapering OFF of Geodon (which has serotonin reuptake effects).
My cocktail is below. Does anyone know if any of these agents could be causing this? If I had to make a guess, I would say that it's gotten worse since I started the Zyprexa 3 weeks ago...is Zyprexa famous for sexual side effects?
Thanks
UncouthAplenzin (bupropion) equivalent to 600mg Wellbutrin
Zyprexa 5mg
Agomelatine 25mg
Geodon 60mg (tapering off)
Lithium 800mg
Deplin 7.5mg
Lunesta 3mg
Deprenyl 2.5mgAlso take:
SAM-e 400mg
L-Tryptophan 2000mg at night (just started, ED was happening before this)
Magnesium Glycinate 400mg
Siberian Ginseng
Ashwangatha
Curcumin
Omega-3 4g
Resveratrol
NAC
Rhodiola
Milk Thistle(God that's a lot)
Posted by Phillipa on October 2, 2009, at 21:18:29
In reply to ED on Wellbutrin and Agomelatine - what gives?!, posted by uncouth on October 2, 2009, at 20:59:21
Uncouth most importantly do you feel better? Phillipa
Posted by uncouth on October 2, 2009, at 22:10:09
In reply to Re: ED on Wellbutrin and Agomelatine - what gives?! » uncouth, posted by Phillipa on October 2, 2009, at 21:18:29
i just moved back to SF after 6 months back home with my parents. the last time i was here was before my 22 rounds of ECT. I thought I had fully recovered from ECT but back in the city there are some definite deficits in spatial memory. It feels like the last time I was here was 10 years ago, not 6 months.
I'm afraid, living on my own again, trying to rebuild my life, looking for a (good) job that I can be engaged in, and grieving over the past losses. And of course the depression. Thankfully, the obsessive suicidal thoughts stopped about 1.5 weeks ago. But i'm scared...lonely...sad for myself...ashamed of being sad for myself...and full of regrets.
But i'm pushing onward. This wasn't the life I expected for myself, not the one I worked hard for, not what people expected of me...but I'm pushing nonetheless. Sometimes I don't know why or for what but I guess that's just the hopelessness. And half the problem is that I dwell on depression so much....on PB, on pubmed...it's become the center of my existence. When other things should be...career...love...and of course God...but for me, it's this depression.
I just wish I could be normal, social, enjoy life, accept, move on, be hopeful, ambitious, romantic, responsible. The sad thing is that to the outside observer, I have the full capacity to be all these things. But looking from the inside-out, it's a different story. But I know i'm not the only one. I don't know what it is -- I accept and trust in biology, but those treatments haven't made me well and haven't changed the trajectory of my life in 6 years. And therapy, same deal, all these insights, the hour a week of baring my soul...and still, same conflicts, same problems, same repeated patterns. It feels imprisoning. But, I hope things get better. Funny I don't focus my prayers on asking God to heal my depression anymore. I don't think it's a lack of faith in his power...i'm just frustrated, and feel as though perhaps this is my lot in life...at least in this life.
Uncouth over and out for now.
Posted by morganator on October 2, 2009, at 22:23:55
In reply to Re: ED on Wellbutrin and Agomelatine - what gives?!, posted by uncouth on October 2, 2009, at 22:10:09
Hey I can very much relate to how you feel. Many people have looked at me and seen so much potential and I just have not been able to accomplish squat. Now, I am struggling more than ever to be the person I want to and should be.
Have you ever tried psychodynamic group therapy? Many people stop going to individual therapy and move on to just group so they can begin to deal with that part of them that forms relationships with others.
Posted by Phillipa on October 3, 2009, at 0:26:46
In reply to Re: ED on Wellbutrin and Agomelatine - what gives?!, posted by uncouth on October 2, 2009, at 22:10:09
Uncouth it's not a good time for the economy and this isn't helping people's mental health either. I also had plans to live in Florida run til age 85 then walk five miles a day on the beach. Ain't happening and won't. I relate to the hopelessness but we all must conquer. Stick with it you will. And you're young a big major plus. Love Phillipa
Posted by bleauberry on October 3, 2009, at 7:22:27
In reply to ED on Wellbutrin and Agomelatine - what gives?!, posted by uncouth on October 2, 2009, at 20:59:21
Of the following list you provided, these are the ones that had bad sexual side effects for me:
Wellbutrin (the worst of all, total ED)
Lithium
Deprenyl 2mg (second worst of all, total ED, don't believe for a second the internet claims on this substance)
Tryptophan
Rhodiola when combined with SSRI, but not by itself.There is so much interaction going on with all of these substances there is no way to figure anything out.
A totally different topic, and I think we've touched on it in other threads, but this cocktail is out of control. Honestly, it should have no more than 3 items out of that 18, maybe 5 with some general tonic herbs in the background.
>
> Aplenzin (bupropion) equivalent to 600mg Wellbutrin
> Zyprexa 5mg
> Agomelatine 25mg
> Geodon 60mg (tapering off)
> Lithium 800mg
> Deplin 7.5mg
> Lunesta 3mg
> Deprenyl 2.5mg
>
> Also take:
> SAM-e 400mg
> L-Tryptophan 2000mg at night (just started, ED was happening before this)
> Magnesium Glycinate 400mg
> Siberian Ginseng
> Ashwangatha
> Curcumin
> Omega-3 4g
> Resveratrol
> NAC
> Rhodiola
> Milk Thistle
>
> (God that's a lot)
Posted by SLS on October 3, 2009, at 7:48:54
In reply to ED on Wellbutrin and Agomelatine - what gives?!, posted by uncouth on October 2, 2009, at 20:59:21
Serotonin 5-HT2c antagonists prevent erections from occurring. However, they can also increase libido acutely, and produce increased testosterone levels subacutely. There is a balance that must be maintained between 5-ht1a 5-ht2a and 5-ht2c receptor activation to maintain healthy sexual function. I guess this leaves agomelatine as a suspect in producing erectile dysfunction, however, I don't know what to attribute reduced libido to, except that the Geodon might still be having a negative impact on it.
- Scott
Posted by uncouth on October 3, 2009, at 9:01:29
In reply to Re: ED on Wellbutrin and Agomelatine - what gives?!, posted by bleauberry on October 3, 2009, at 7:22:27
yeah, i guess your right. i know, it's impossible to determine interaction effects. i'm coming off geodon as the first thing i need to remove. i'm hesitant to remove deprenyl as it seems to be very pro-neurotrophic at even low doses, and i'm hoping the PEA that is released when i exercise can have an extended effect in the presence of deprenyl. but this is just an amateur theory.
i will try lowering the rhodiola. man i'd hate it if the ED was due to agomelatine!
i think SAM-e AND deplin combined might be overkill, too.
Posted by bearfan on October 6, 2009, at 20:17:53
In reply to Re: ED on Wellbutrin and Agomelatine - what gives?!, posted by SLS on October 3, 2009, at 7:48:54
I don't think you can pinpoint it to just one drug. You are on quite a bit of drugs and overdrugging your body is going to cause health problems. ED can sometimes be psychological, and if diet and exercise are poor. The anti-psychotic may be the culprit, but I've read studies and (reports from users) that high dopatraneourgic drugs cause ED in the long term. This includes drugs like Adderall, Cocaine etc.
Posted by morganator on October 6, 2009, at 21:54:17
In reply to Re: ED on Wellbutrin and Agomelatine - what gives?!, posted by morganator on October 2, 2009, at 22:23:55
OOOps!!! that post was meant for another thread!!
Posted by morganator on October 6, 2009, at 22:03:25
In reply to Re: ED on Wellbutrin and Agomelatine - what gives?!, posted by uncouth on October 3, 2009, at 9:01:29
Yeah I would definitely try to reduce the amount of psychiatric medications you are on.
This is the end of the thread.
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