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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by fellowmike on August 27, 2009, at 16:37:58
i was just wondering if lyrica could enhance TCA levels or TCA AD effects or if it decreases the blood levels or the AD effects ??
thanks:]
Posted by SLS on August 28, 2009, at 11:26:04
In reply to how does lyrica affect TCA levels???, posted by fellowmike on August 27, 2009, at 16:37:58
> i was just wondering if lyrica could enhance TCA levels or TCA AD effects or if it decreases the blood levels or the AD effects ??
I don't know.
Lyrica (pregabalin) is eliminated through the kidneys unchanged, much like Neurontin (gabapentin). Therefore, it would not affect the enzymatic metabolism of TCA. TCA levels should be remain unaffected.
Whether or not Lyrica can enhance the antidepressant effect of TCA is hard to predict. Like so many combination treatments, it is really a trial-and-error process to evaluate a treatment's effectiveness.
Are you bipolar?
- Scott
Posted by fellowmike on August 28, 2009, at 14:00:10
In reply to Re: how does lyrica affect TCA levels???, posted by SLS on August 28, 2009, at 11:26:04
well i guess im a certain kind of bipolar, the doctor classifed me as agitated depression
Posted by SLS on August 28, 2009, at 14:31:31
In reply to Re: how does lyrica affect TCA levels??? » SLS, posted by fellowmike on August 28, 2009, at 14:00:10
> well i guess im a certain kind of bipolar, the doctor classifed me as agitated depression
Agitated depression often responds to tricyclics.
What drugs are you currently taking?
- Scott
Posted by bulldog2 on August 29, 2009, at 13:23:59
In reply to Re: how does lyrica affect TCA levels???, posted by SLS on August 28, 2009, at 11:26:04
> > i was just wondering if lyrica could enhance TCA levels or TCA AD effects or if it decreases the blood levels or the AD effects ??
>
> I don't know.
>
> Lyrica (pregabalin) is eliminated through the kidneys unchanged, much like Neurontin (gabapentin). Therefore, it would not affect the enzymatic metabolism of TCA. TCA levels should be remain unaffected.
>
> Whether or not Lyrica can enhance the antidepressant effect of TCA is hard to predict. Like so many combination treatments, it is really a trial-and-error process to evaluate a treatment's effectiveness.
>
> Are you bipolar?
>
>
> - ScottScott are you sure about lyrica and the kidneys? I know that's how neurontin works. But I thought the way lyrica was enhanced was it was broken down by the kidneys so you can have higher levels of the drug in your system.
This is the end of the thread.
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