Psycho-Babble Medication Thread 914414

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how does lyrica affect TCA levels???

Posted by fellowmike on August 27, 2009, at 16:37:58

i was just wondering if lyrica could enhance TCA levels or TCA AD effects or if it decreases the blood levels or the AD effects ??

thanks:]

 

Re: how does lyrica affect TCA levels???

Posted by SLS on August 28, 2009, at 11:26:04

In reply to how does lyrica affect TCA levels???, posted by fellowmike on August 27, 2009, at 16:37:58

> i was just wondering if lyrica could enhance TCA levels or TCA AD effects or if it decreases the blood levels or the AD effects ??

I don't know.

Lyrica (pregabalin) is eliminated through the kidneys unchanged, much like Neurontin (gabapentin). Therefore, it would not affect the enzymatic metabolism of TCA. TCA levels should be remain unaffected.

Whether or not Lyrica can enhance the antidepressant effect of TCA is hard to predict. Like so many combination treatments, it is really a trial-and-error process to evaluate a treatment's effectiveness.

Are you bipolar?


- Scott

 

Re: how does lyrica affect TCA levels??? » SLS

Posted by fellowmike on August 28, 2009, at 14:00:10

In reply to Re: how does lyrica affect TCA levels???, posted by SLS on August 28, 2009, at 11:26:04

well i guess im a certain kind of bipolar, the doctor classifed me as agitated depression

 

Re: how does lyrica affect TCA levels??? » fellowmike

Posted by SLS on August 28, 2009, at 14:31:31

In reply to Re: how does lyrica affect TCA levels??? » SLS, posted by fellowmike on August 28, 2009, at 14:00:10

> well i guess im a certain kind of bipolar, the doctor classifed me as agitated depression

Agitated depression often responds to tricyclics.

What drugs are you currently taking?


- Scott

 

Re: how does lyrica affect TCA levels???

Posted by bulldog2 on August 29, 2009, at 13:23:59

In reply to Re: how does lyrica affect TCA levels???, posted by SLS on August 28, 2009, at 11:26:04

> > i was just wondering if lyrica could enhance TCA levels or TCA AD effects or if it decreases the blood levels or the AD effects ??
>
> I don't know.
>
> Lyrica (pregabalin) is eliminated through the kidneys unchanged, much like Neurontin (gabapentin). Therefore, it would not affect the enzymatic metabolism of TCA. TCA levels should be remain unaffected.
>
> Whether or not Lyrica can enhance the antidepressant effect of TCA is hard to predict. Like so many combination treatments, it is really a trial-and-error process to evaluate a treatment's effectiveness.
>
> Are you bipolar?
>
>
> - Scott

Scott are you sure about lyrica and the kidneys? I know that's how neurontin works. But I thought the way lyrica was enhanced was it was broken down by the kidneys so you can have higher levels of the drug in your system.


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