![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Darwin on June 26, 2009, at 15:37:33
"The widely used antidepressant and pain medication amitriptyline--but not other closely related drugs -- can impersonate the brain's own growth factors, researchers at Emory University School of Medicine have shown."
Here's the complete article:
Posted by bulldog2 on June 26, 2009, at 17:43:01
In reply to Amitriptyline directly stimulates NGF receptors, posted by Darwin on June 26, 2009, at 15:37:33
>
>
> "The widely used antidepressant and pain medication amitriptyline--but not other closely related drugs -- can impersonate the brain's own growth factors, researchers at Emory University School of Medicine have shown."
>
> Here's the complete article:
>
> http://www.physorg.com/news165152571.htmlRemarkable compound!
Posted by linkadge on June 26, 2009, at 17:58:43
In reply to Re: Amitriptyline directly stimulates NGF receptors, posted by bulldog2 on June 26, 2009, at 17:43:01
Interesting
Linkadge
Posted by Phillipa on June 26, 2009, at 21:54:40
In reply to Amitriptyline directly stimulates NGF receptors, posted by Darwin on June 26, 2009, at 15:37:33
Seriously still want to know what the TCA was they gave me at age 24 with first panic attack that literally drove me crazy and I walked the street crying all night. Was called an upper downer by the pdoc. I only took that one dose. Was intolerable. Phillipa
Posted by bulldog2 on June 27, 2009, at 17:32:04
In reply to Re: Amitriptyline directly stimulates NGF receptors, posted by Phillipa on June 26, 2009, at 21:54:40
> Seriously still want to know what the TCA was they gave me at age 24 with first panic attack that literally drove me crazy and I walked the street crying all night. Was called an upper downer by the pdoc. I only took that one dose. Was intolerable. Phillipa
This is a thread about amitriptyline stimulating NGF receptors. What does your post have to do with the above topic ? Perhaps you could start a new thread about your question. A topic has more value if people stick to the topic posted. If people start guessing what TCA you took the original thread becomes lost. It also is not fair to the poster who started the thread. However your post may make for an interesting topic if you started a new thread.
Posted by Brainbeard on June 28, 2009, at 8:27:07
In reply to Amitriptyline directly stimulates NGF receptors, posted by Darwin on June 26, 2009, at 15:37:33
>
>
> "The widely used antidepressant and pain medication amitriptyline--but not other closely related drugs -- can impersonate the brain's own growth factors, researchers at Emory University School of Medicine have shown."
>
> Here's the complete article:
>
> http://www.physorg.com/news165152571.htmlVery interesting. My next question would be: is this effect dose-related? Amitriptyline can mitigate pain at low dosages (in the range of even 5 to 50mg). If its analgetic qualities are related to the phenomenon discussed, amitriptyline might exert these brain repairing(/enhancing?) actions even at low doses.
I've just received a bunch of amitriptyline and have just started using it low dose. I take it for chronic pain and for its anxiolytic 5HT2A-antagonism, which may also counter SSRI-induced apathy related to decreased noradrenaline firing if I understand this abstract correctly: http://www.journals.elsevierhealth.com/periodicals/bps/article/PIIS0006322306006597/abstract.
-------------------------------------------------
Current meds: imipramine 12.5mg, sertraline 12.5mg, amitriptyline 6mg, ondansetron 2mg several times a day, modafinil 50mg
-------------------------------------------------
Posted by morganpmiller on June 29, 2009, at 1:28:34
In reply to Amitriptyline directly stimulates NGF receptors, posted by Darwin on June 26, 2009, at 15:37:33
Or we can try taking Acetyl L Carnitine 2 or 3 times a day on an empty stomach.
b;29(1):55-66.Links
Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats.
Taglialatela G, Navarra D, Cruciani R, Ramacci MT, Alemà GS, Angelucci L.Institute for Research on Senescence Sigma-Tau, Pomezia, Italy.
The hypothesis that some neurodegenerative events associated with ageing of the central nervous system (CNS) may be due to a lack of neurotrophic support to neurons is suggestive of a possible reparative pharmacological strategy intended to enhance the activity of endogenous neurotrophic agents. Here we report that treatment with acetyl-l-carnitine (ALCAR), a substance which has been shown to prevent some impairments of the aged CNS in experimental animals as well as in patients, is able to increase the levels and utilization of nerve growth factor (NGF) in the CNS of old rats. The stimulation of NGF levels in the CNS can be attained when ALCAR is given either for long or short periods to senescent animals of various ages, thus indicating a direct effect of the substance on the NGF system which is independent of the actual degenerative stage of the neurons. Furthermore, long-term treatment with ALCAR completely prevents the loss of choline acetyltransferase (ChAT) activity in the CNS of aged rats, suggesting that ALCAR may rescue cholinergic pathways from age-associated degeneration due to lack of retrogradely transported NGF.
Some think Acetyl L Carnitine Arginate is better. Many recommend taking Acetyl L Carnitine with Lipoic Acid as they may work synergistically. Stabilized Na R lipoic acid is the best form of lipoic acid.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.