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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on June 18, 2009, at 13:12:27
I have realized that using atypical AP's for sleep can be beneficial. They can calm down an overactive mind.
However, I don't like taking atypicals since they take too long to leave the system.
Which AP's have the shortest half life?
Linkadge
Posted by Phillipa on June 18, 2009, at 13:52:45
In reply to Short acting AP for sleep, posted by linkadge on June 18, 2009, at 13:12:27
You don't like lunsta or ambien or a benzo? Or even temazapam? Why an atypical? Love Phillipa
Posted by SLS on June 18, 2009, at 14:08:36
In reply to Short acting AP for sleep, posted by linkadge on June 18, 2009, at 13:12:27
> I have realized that using atypical AP's for sleep can be beneficial. They can calm down an overactive mind.
>
> However, I don't like taking atypicals since they take too long to leave the system.
>
> Which AP's have the shortest half life?
Seroquel has a half-life of only 6 hours. Maybe that is why it is used so often as a hypnotic. Hopefully, a dose as small as 25mg should do the job.Good luck.
- Scott
Posted by Frustratedmama on June 18, 2009, at 15:28:14
In reply to Re: Short acting AP for sleep » linkadge, posted by Phillipa on June 18, 2009, at 13:52:45
> You don't like lunsta or ambien or a benzo? Or even temazapam? Why an atypical? Love Phillipa
So funny, Phillipa, I just posted the same meds in advice to above poster..... LOL
Posted by bleauberry on June 18, 2009, at 19:33:55
In reply to Short acting AP for sleep, posted by linkadge on June 18, 2009, at 13:12:27
Hi Link,
Hey, Seroquel has the shortest halflife I know of. The problem is that the sedation and fogginess can last well through the next day despite that most of the drug is gone. I don't know why that is. I know I am not the first or only person to complain about that. There have been many. In addition to that, this board's history is chock full of people complaining about Seroquel's sleep-enhancement poopout.
I actually didn't find it very good, except for initiating sleep. If you want something to knock you out, Seroquel can do that. At least for a while before tolerance builds. The problem with me was that I only slept good for maybe 3 or 4 hours, and then I was kind of tossing and turning after that, with bizarra scary AP type dreams, and then a real tired fatigued day. I didn't like it at all. Some people love it though.
For sleep, my personal feeling is that low dose (10mg-25mg) Amitriptyline is probably the best. It rarely has poopout attached to it. In addition, even at those low doses, it can contribute to other things such as anti-pain, anti-depression, anti-fatigue. Granted, the tiredness of a TCA like that carries through the next day for a few weeks. But people I know who have been on it for months say that no longer happens after a few weeks, but the good sleep continues. The sleep architecture of it is good, where the sleep architecture of APs really isn't that good. Amitriptyline is I think the only one I know of where the good sleep doesn't poop out. With amitriptyline, you don't have the dopamine blockade risks and such associated with APs.
Everyone is different. My favorite sleep meds were, in order of preference:
1. Amitriptyline 10mg
2. Lunesta half dose
3. 2mg-7.5mg Remeron
4. 5mg Zyprexa
Posted by Phillipa on June 18, 2009, at 22:01:24
In reply to Re: Short acting AP for sleep, posted by Frustratedmama on June 18, 2009, at 15:28:14
Well we're on the same page. Check out thread thyroid. Phillipa
Posted by Zyprexa on June 19, 2009, at 0:20:29
In reply to Short acting AP for sleep, posted by linkadge on June 18, 2009, at 13:12:27
Perphenazine is 9 hours.
This is the end of the thread.
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