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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on June 14, 2009, at 8:03:13
Apparently inositol has little to no value as an adjunct to refractory SSRI users. Perhaps because both agents are working on the serotonergic system.
I wonder if inositol would be a good adjunct to those who are partially responding to an NRI? In this sense, the NRI and inositol might be activating complimentary neurotransmitter systems.
Anyone tried this? Say inostol plus wellbutrin, nortriptyline or desiprmine?
Linkadge
Posted by SLS on June 14, 2009, at 9:24:25
In reply to Inositol to augment NRI's, posted by linkadge on June 14, 2009, at 8:03:13
> Apparently inositol has little to no value as an adjunct to refractory SSRI users. Perhaps because both agents are working on the serotonergic system.
>
> I wonder if inositol would be a good adjunct to those who are partially responding to an NRI? In this sense, the NRI and inositol might be activating complimentary neurotransmitter systems.
>
> Anyone tried this? Say inostol plus wellbutrin, nortriptyline or desiprmine?
Those are real good thoughts.How does inositol become serotonergic in particular? Is it a membrane thing or a second messenger thing? Neither? Calcium channel thing? A quick look at Wikipedia didn't really address this issue, or I must have missed it. One thing for sure, though, is that they reported efficacy for inositol in OCD, which would lead one to believe that serotonin is involved.
- Scott
Posted by linkadge on June 14, 2009, at 11:21:10
In reply to Re: Inositol to augment NRI's » linkadge, posted by SLS on June 14, 2009, at 9:24:25
I've heard a couple of things - that inositol increases the responsiveness of serotoninergic neurons and that it acts as a second messenger to the serotonergic system.
Linkadge
Posted by Phillipa on June 14, 2009, at 12:02:35
In reply to Re: Inositol to augment NRI's » linkadge, posted by SLS on June 14, 2009, at 9:24:25
If inositol which I have in the cabinet is a b vitamin found in many foods such as cantaloupe how can it work as a drug wouldn't it have to be regulated by FDA? And if you get too many B's excreated in that lovely bright yellow urine. I don't get how it could be a drug. If so to me that seems to also make serotonin a supplement as in the gut. So if no gut problems ever with serotonin what does that mean? Since digoxin and other meds are also from nature. Why not just eat a good diet? Phillipa ps plus vitamins are expensive
Posted by sam K on June 15, 2009, at 9:26:19
In reply to Re: Inositol to augment NRI's, posted by Phillipa on June 14, 2009, at 12:02:35
yea, figuring that nri's are stimulant like. To me, inositol is like a downer to me. It takes away anxiety but makes depression. Makes me really sleepy too. Like xanax
Posted by mogger on June 18, 2009, at 23:55:29
In reply to Re: Inositol to augment NRI's, posted by sam K on June 15, 2009, at 9:26:19
I am on 18 grams a day on top of my 200 mg zoloft and they go great together.
Posted by desolationrower on June 19, 2009, at 18:32:29
In reply to Re: Inositol to augment NRI's, posted by mogger on June 18, 2009, at 23:55:29
i think it is related to inositol cycle secondary messangers and 5ht receptor availibility. i don't think there is a good theory. most of the things on how it works are actually from Lithium research. its mostly guesswork i don't have any good reviews i've ever seen.
-d/r
This is the end of the thread.
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