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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by linkadge on June 4, 2009, at 19:05:53
While seroquel does have some antidepressant effects. I still get some really unwelcome yucky dysphoria like effects on it. Its not really a miracle drug. I would still personally use low dose TCA for many of the same purposes.
I think low dose TCA agumentation is still underutilized. I think many people could switch to say amitriptyline or doxapin for the same purposes and probably exprience fewer side effects.
Linkadge
Posted by SLS on June 4, 2009, at 19:33:04
In reply to Seroquel is still an antipsychotic, posted by linkadge on June 4, 2009, at 19:05:53
> While seroquel does have some antidepressant effects. I still get some really unwelcome yucky dysphoria like effects on it.
Me too.
> Its not really a miracle drug.
I don't think there is such a thing EXCEPT for the drug that works for you or me.
> I would still personally use low dose TCA for many of the same purposes.
>
> I think low dose TCA agumentation is still underutilized. I think many people could switch to say amitriptyline or doxapin for the same purposesThose would be exactly my choices.
> and probably exprience fewer side effects.
Seroquel can be a very clean drug for some people. I think it is important to note that the lower dosages tend to produce somnolence, whereas this is an infrequent occurrence at the higher dosages. The diabetes thing is a real concern, but I really don't know with what frequency it occurs. I'm sure some people would welcome the lack of always looking over their shoulder for irreversible tardive EPS from occuring, despite it being a rare occurence.
When I take all of this into consideration, I have very little trepidation in using lower dosages for sleep and anxiolysis when treating people whom do not suffer from psychotic conditions. I have seen Seroquel produce a remarkable antidepressant effect, but it was in the context of polypharmacy.
- Scott
Posted by linkadge on June 4, 2009, at 20:06:53
In reply to Re: Seroquel is still an antipsychotic » linkadge, posted by SLS on June 4, 2009, at 19:33:04
I think it can produce a good antidepressant effect. In some ways thought it is very similar to a TCA. Isn't it a modified TCA?
What I think though is that it is being used in a lot of people who havn't been tried on a TCA. I just feel metabolically yukky on seroquel. Like I've eaten too much McDonnald's food or something.
I had a little of that on the TCA's but it wasn't as bad.
Linkadge
Posted by Phillipa on June 4, 2009, at 20:36:11
In reply to Re: Seroquel is still an antipsychotic, posted by linkadge on June 4, 2009, at 20:06:53
12.5mg knocked me out where benzos do not much now. But don't the TCA's carry a lot of weight gain? Phillipa
Posted by yxibow on June 5, 2009, at 10:40:17
In reply to Seroquel is still an antipsychotic, posted by linkadge on June 4, 2009, at 19:05:53
> While seroquel does have some antidepressant effects. I still get some really unwelcome yucky dysphoria like effects on it. Its not really a miracle drug. I would still personally use low dose TCA for many of the same purposes.
Well it helped me a long time for its purpose -- it is still keeping me together though my disorder and the transmitters have probably shifted.
The 'dysphoria' is probably the blunting aspect of some neuroleptics.
> I think low dose TCA agumentation is still underutilized. I think many people could switch to say amitriptyline or doxapin for the same purposes and probably exprience fewer side effects.
>
> LinkadgeOh there are side effects of TCAs -- the Anafranil I take isn't the cleanest of agents.
I thought you were concerned about 'genotoxicity' of TCAs, which I do think in my opinion is a low concern compared to untreated major depression.
I have found some TCAs to be wierd at times, like doxepin, but that is probably due to the mix of medications I suppose.
Flexeril was odd too as a muscle relaxant, as it is sort of basically a TCA.
Amitriptyline was okay as a sleep aid.
But, we all have individual experiences.
-- Jay
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