Shown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by shasling on April 12, 2009, at 17:14:07
Scott you might have some input here,GHB is a gaba b drug,yess its illegal now however its also legal as a prescription slee drug called xyrem.
With parnate having gaba b properties,in theory would you think ghb would poteniate that and work well with it?
Posted by SLS on April 12, 2009, at 18:31:38
In reply to Opinions, posted by shasling on April 12, 2009, at 17:14:07
> Scott you might have some input here,GHB is a gaba b drug,yess its illegal now however its also legal as a prescription slee drug called xyrem.
>
> With parnate having gaba b properties,in theory would you think ghb would poteniate that and work well with it?Actually, you could do me a favor and hook me up with a URL link that reports Parnate having GABA-B properties. I was unaware of this.
Even though I responded poorly to Provigil, it might be a wonderful complement to Parnate in that it would enhance its antidepressant effect and help reduce the daytime sleepiness that many complain of with Parnate.
Adding GHB to any MAOI is an interesting proposition. I haven't a clue as to how it would affect the quality of the antidepressant response, but it might help with MAOI-induced insomnia and allow for more energetic waking hours.
- Scott
Posted by shasling on April 12, 2009, at 19:10:36
In reply to Re: Opinions, posted by SLS on April 12, 2009, at 18:31:38
Heres the snip
"The irreversible inhibitor of monoamine oxidase, tranylcypromine, is a potent antidepressant, but its use is limited to special indications due to side effects and dietary restrictions. The antidepressant action of tranylcypromine is not completely explainable by its effects on monoamine oxidase. Tranylcypromine also leads to an increase in brain trace amines, which are believed to play a key role in the pathophysiology of depression. It also affects other pathophysiological pathways associated with depression. Tranylcypromine treatment leads to an up-regulation of GABA(B)-receptors and modulates the phospholipid metabolism, which is essential for normal brain function. These findings implicate that the efficacy of tranylcypromine as an antidepressant may be due to its multiple actions within the human brain."
The site url is
http://biopsychiatry.com/tranylcypromine-parnate.htmso it says it upregualtes gaba b.
Posted by linkadge on April 12, 2009, at 20:17:51
In reply to Re: Opinions, posted by shasling on April 12, 2009, at 19:10:36
The upregulation of gaba-b may or may not lead to an increased net activation of gaba-b recepors.
Perhaps they are being increased as an inhibitory adaptive responce to the drug.
Linkadge
Posted by metric on April 13, 2009, at 17:59:03
In reply to Re: Opinions, posted by linkadge on April 12, 2009, at 20:17:51
> The upregulation of gaba-b may or may not lead to an increased net activation of gaba-b recepors.
>
> Perhaps they are being increased as an inhibitory adaptive responce to the drug.That was my first thought.
To the original poster: as someone who has used both GHB (lots of it) and tranylcypromine (Parnate), the subjective effects are not remotely similar, although both drugs are euphoriants.
If you want a GABA-B agonist, there is always baclofen, which is non-scheduled and thus easy to obtain. Another option is phenibut, which at very high doses seemed weakly reminscent of GHB, although tolerance developed rapidly. Phenibut can be purchased as a "dietary supplement" in the U.S.
Posted by metric on April 13, 2009, at 18:03:32
In reply to Opinions, posted by shasling on April 12, 2009, at 17:14:07
> Scott you might have some input here,GHB is a gaba b drug,yess its illegal now however its also legal as a prescription slee drug called xyrem.
>
> With parnate having gaba b properties,in theory would you think ghb would poteniate that and work well with it?Do you have narcolepsy? If not, there is no chance in hell that a doctor is going to prescribe you Xyrem.
Also, why do you want it? It causes intense rebound anxiety when used frequently.
Posted by yxibow on April 13, 2009, at 23:27:39
In reply to Re: Opinions » shasling, posted by metric on April 13, 2009, at 18:03:32
> > Scott you might have some input here,GHB is a gaba b drug,yess its illegal now however its also legal as a prescription slee drug called xyrem.
> >
> > With parnate having gaba b properties,in theory would you think ghb would poteniate that and work well with it?
>
> Do you have narcolepsy? If not, there is no chance in hell that a doctor is going to prescribe you Xyrem.
Probably not, if they want to keep their license. Those who used it 'recreationally' may argue otherwise but its a serious compound not to be taken lightly.-- Jay
Posted by Sigismund on April 13, 2009, at 23:36:38
In reply to Re: Opinions » metric, posted by yxibow on April 13, 2009, at 23:27:39
When I got hold of agomelatine my psych said
'If it's any good they'll ban it'
Posted by desolationrower on April 14, 2009, at 1:48:54
In reply to Re: Opinions » yxibow, posted by Sigismund on April 13, 2009, at 23:36:38
> When I got hold of agomelatine my psych said
> 'If it's any good they'll ban it'oh, maybe not. with MAOIs they just said 'they're dangerous!' and won't prescribe them.
-d/r
This is the end of the thread.
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