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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by X-ray on December 5, 2008, at 10:37:23
Hi,
I have been on Elavil (amitriptyline) for many years, but now I'm going to try mianserin (for sleep).
B R Ballinger and J Feely about mianserin in an article in British Medical Journal:
- Its profile of action differs considerably from the tricyclic antidepressants (amitriptyline) as it does not block amine uptake.Can anyone explain what this means?
How does mianserin work compared to amitriptyline?Best regards,
X-ray
Posted by SLS on December 5, 2008, at 12:19:24
In reply to Mianserin vs. Elavil, posted by X-ray on December 5, 2008, at 10:37:23
> Hi,
>
> I have been on Elavil (amitriptyline) for many years, but now I'm going to try mianserin (for sleep).
>
> B R Ballinger and J Feely about mianserin in an article in British Medical Journal:
> - Its profile of action differs considerably from the tricyclic antidepressants (amitriptyline) as it does not block amine uptake.
>
> Can anyone explain what this means?
> How does mianserin work compared to amitriptyline?
>
> Best regards,
> X-ray
>Hi.
Mianserin works in a way very similar to Remeron, only with greater antihistaminic effects. Both drugs share the properties of NE alpha-2 receptor antagonism (blocking) and 5-HT2 receptor antagonism. The first property causes the presynaptic neuron to manufacture and release more norepinephrine neurotransmitter. The second property helps to maintain a balance of serotonin and dopamine.
Neither drug acts as a reuptake inhibitor of a neurotransmitter the way amitriptyline and most other antidepressants do. They do not allow the presynaptic neuron to suck up and recycle its neurotransmitter, thereby causing an increase in the synaptic concentration of that neurotransmitter.
- Scott
Posted by X-ray on December 7, 2008, at 4:46:57
In reply to Re: Mianserin vs. Elavil, posted by SLS on December 5, 2008, at 12:19:24
Hi Scott,
Thank's for your reply!
I have been on Remeron for six months, but I finally decided that Elavil suited me better.
Now I'm going to try Tolvon.
The crucial question:
Is Tolvon better for sleep than Remeron?I shall soon find out.
Best regards,
X-ray
This is the end of the thread.
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