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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by uncouth on November 21, 2008, at 14:57:31
I'm on day 3 of tianeptine, added to my current regimine of 80mg parnate, 2.5mg abilify, and 450mg lithium.
Just wanted to let people know that there hasn't seemed to be any negative interactions with tianeptine and parnate, and tianeptine had an immediate positive impact on anxiety, felt like a small dose of xanax, but with no sedation.
We'll see if the trial continues to be positive, but I just can't seem to ignore all the amazing anti-stress and neurotrophic things tianeptine uniquely does (see tianeptine.com), and combining it with parnate isn't necessarily advised, but so far, is safe.
However, tianeptine may have a longer-acting pro-serotonin element, so I am watching for serotonin syndrome symptoms. I should note that I also take 1mg of Tryptophan on occasion with parnate and that doesn't seem to be a problem either. But I did just recently increase my dose to 80 from 60, so things could always change.
Taking risks, but necessary ones. This depression has just lasted far too long and taken way too many things from my life.
My agomelatine should arrive soon also. Intend to add it on to my current regime.
Posted by desolationrower on November 21, 2008, at 17:58:06
In reply to Parnate plus TIaneptine, posted by uncouth on November 21, 2008, at 14:57:31
Interesting, i'll want to hear about how it goes. Do you have a serotonin syndrome antidote on hand? For experimental combinations i think that would be good.
Have you had tianeptine before, and how did you find it on its own?\\
-d/r
Posted by CaptainAmerica1967 on November 21, 2008, at 21:17:40
In reply to Parnate plus TIaneptine, posted by uncouth on November 21, 2008, at 14:57:31
When did agomelatine get approved?
See the below website address for future antidepressant drugs and expected approval date
www.neurotransmitter.net/newdrugs.html
Posted by Phillipa on November 22, 2008, at 0:39:38
In reply to agomelatine, posted by CaptainAmerica1967 on November 21, 2008, at 21:17:40
If not approved how would you obtain it? Phillipa or is it just not approved in the States?
Posted by CaptainAmerica1967 on November 22, 2008, at 10:12:16
In reply to Re: agomelatine » CaptainAmerica1967, posted by Phillipa on November 22, 2008, at 0:39:38
I just went to LES LABORATOIRES SERVIER website via the below website and it states it will not be approved in the UK until 2009 sometime.
http://www.neurotransmitter.net/newdrugs.html
Positive opinion from the European Medicine Agency for the new antidepressant Valdoxan:
On 20th of November 2008, the committee for Medicinal Products for Human Use adopted a positive opinion, recommending to grant a marketing authorisation for the Servier new antidepressant Valdoxan 25mg, for the treatment of major depressive episodes in adults. Valdoxan is an innovative new approach to the treatment of depression and has proven efficacy across a wide range of patients, including the most severely depressed.
Valdoxan, discovered and developped by Servier, is the first melatonergic antidepressant, acting by resynchronizing circadian rhythms.
Upon approval by the European Commission expected in early 2009, Valdoxan will be available in European countries in the following months.
Posted by uncouth on November 22, 2008, at 12:29:34
In reply to Re: Parnate plus TIaneptine, posted by desolationrower on November 21, 2008, at 17:58:06
not sure waht the antidote would be, but i think if i downed a larger dose of abilify the 5-ht2a antagonism might help in an acute situation. obviously i'd go to the hospital too.
tried tianeptine briefly on its own. always had a slight positive effect, specifically with anxiety. but i'm treating tianeptine almost like I treat low dose lithium -- an important "supplement" that is proven to make actual morphological changes in neurons, especially with respect to stress. so i'm not looking at it for it's primary a/d properties, i figure parnate is my main line for that.
we'll see. i know this is a unconventional strategy, and im' taking a lot of meds (low dose lithium, low dose seroquel for sleep, high dose of parnate, low dose of abilify, and now tianeptine 3x/day, along with omega-3, NAC, B-vitamins, and occasionally l-tryptophan), but, by gosh, I am starting to FEEL BETTER.
may also add on a 100mg dose of lamictal after i spend a few weeks on tianeptine.
I figure as long as the drugs don't hit the same receptors, and don't have metabolic interactions, they should be relatively safe to combine as long as not specified otherwise. For someone very sick, and with BP2 diagnosis, I think it's important to be on (at least a low dose) of every category of drug (mood stabilizer, a/d, antipsychotic, hypnotic, potentially a stimulating agent) if other more traditional methods haven't worked.
If I want my brain actually healed, I need healing substances, and all chemicals heal different things in different ways, right?
BP2 is complex and hard to treat on the depressive side.
Posted by desolationrower on November 22, 2008, at 15:25:18
In reply to Re: Parnate plus TIaneptine » desolationrower, posted by uncouth on November 22, 2008, at 12:29:34
I agree with your approach, good luck with it. I think some of us have a number of imbalances in our brain and its important to get as many of them back to normal as possible.
Personally i keep some cyproheptadine as it is the standard antidote for serotonin syndrome. I would not be confident the emergency room would know how to treat ss, especially if i were to be unconscious before i got there. It is available OTC in canada at least.
using aripiprazole i would be hesitant because it isn't a strong 5ht2a antagonist, and one of the main treatments is chlorpromazine, also and antipsychotic. Seems sketchy to have all that neuroleptics in your system.
-d/r
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