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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Maria3667 on November 19, 2008, at 15:27:01
Darn!! I just knew it!
See below.
Maria
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Adults with primary insomnia have a specific neurochemical imbalance that makes it more difficult for their brains to settle down for sleep, a new study says.
People with primary insomnia for more than six months have 30 percent less gamma-aminobutyric acid (GABA), a chemical that slows overall activity in many brain areas, according to the report in the Nov. 1 issue of Sleep. A "racing mind" and an inability to shut down at night is a common complaint of people with primary insomnia.
"GABA is reduced in the brain of individuals with insomnia, suggesting overactivity is present not only at the level of excessive thoughts and emotions, but can also be detected at the level of the nervous system," principal investigator John Winkelman of Brigham and Women's Hospital, in Boston, said in an American Academy of Sleep Medicine news release.
While most insomnia occurs in conjunction with another illness or disorder, either physical or mental, or as a side effect of certain medications or substances, primary insomnia occurs without a coexisting condition. Approximately a quarter of people with insomnia suffer from this particular type of the sleep disorder.
The finding suggests that primary insomnia is a manifestation of hyperarousal, a neurobiological state, that Winkelman said helps validate an often misunderstood complaint of insomnia.
"Recognition that insomnia has manifestations in the brain may increase the legitimacy of those who have insomnia and report substantial daytime consequences," he said. "Insomnia is not just a phenomenon observed at night, but has daytime consequences for energy, concentration and mood."
Lower brain GABA levels also have been found in people with major depressive disorder (MDD) and anxiety disorders. As primary insomnia is a critical risk factor in these conditions, the findings could mean GABA deficiencies seen in people with mood and anxiety disorders may be tied to sleep disturbances.
Many of the hypnotic medications most effective in treating insomnia are benzodiazepine receptor antagonists (BzRAs), which increase activity at the GABA neurons, the study also reported.
Please follow the link to read more:
www.life-extension-drugs.com/Primary Insomnia Tied to Brain Neurochemical Imbalance (news from life-extension-drugs.com)‏
From: life-extension-drugs.com
_________________________Primary Insomnia Tied to Brain Neurochemical Imbalance
Finding suggests complaint of a 'racing mind' is not just in patient's head
www.life-extension-drugs.com/
_________________________
Posted by Phillipa on November 19, 2008, at 20:27:40
In reply to Insomnia Tied to Brain Neurochemical Imbalance, posted by Maria3667 on November 19, 2008, at 15:27:01
Maria so now how do we get more Gaba????Love Phillipa
Posted by Maria3667 on November 20, 2008, at 4:45:18
In reply to Re: Insomnia Tied to Brain Neurochemical Imbalance » Maria3667, posted by Phillipa on November 19, 2008, at 20:27:40
Hi Phillipa (!),
Well, let's try to make some ourselves and then distribute cheaply amongst other Babblers?
Love,
Maria
Posted by bulldog2 on November 20, 2008, at 14:32:05
In reply to Re: Insomnia Tied to Brain Neurochemical Imbalance » Maria3667, posted by Phillipa on November 19, 2008, at 20:27:40
> Maria so now how do we get more Gaba????Love Phillipa
Nardil prevents the destruction of gaba and therby increases levels of the neurochem.
Posted by Maria3667 on November 20, 2008, at 15:27:31
In reply to Re: Insomnia Tied to Brain Neurochemical Imbalance, posted by bulldog2 on November 20, 2008, at 14:32:05
Hi BD,
So what you are saying is: it increases Gaba?
I always get so confused at this neurotransmitter business... upregulation... downregulation... agonist ... antagonists... Blow me!
Best wishes,
Maria
> > Maria so now how do we get more Gaba????Love Phillipa
>
> Nardil prevents the destruction of gaba and therby increases levels of the neurochem.
Posted by Phillipa on November 20, 2008, at 18:45:48
In reply to Re: Insomnia Tied to Brain Neurochemical Imbalance, posted by bulldog2 on November 20, 2008, at 14:32:05
Bulldog is this your next med plan? Love Phillipa
Posted by bulldog2 on November 20, 2008, at 19:34:43
In reply to Re: Insomnia Tied to Brain Neurochemical Imbalance » bulldog2, posted by Maria3667 on November 20, 2008, at 15:27:31
> Hi BD,
>
> So what you are saying is: it increases Gaba?
>
> I always get so confused at this neurotransmitter business... upregulation... downregulation... agonist ... antagonists... Blow me!
>
> Best wishes,
> Maria
>
>
> > > Maria so now how do we get more Gaba????Love Phillipa
> >
> > Nardil prevents the destruction of gaba and therby increases levels of the neurochem.
>
>yes it inceases gaba.
Posted by Michael Bell on November 21, 2008, at 9:01:56
In reply to Insomnia Tied to Brain Neurochemical Imbalance, posted by Maria3667 on November 19, 2008, at 15:27:01
This makes sooooooooo much sense! I had terrible insomnia (slow sleep onset - I'm talking hours) my entire life until I tried Picamilon when I was about 25. It is like my brain was given something it was looking for all this time. Now my insomnia is gone and I haven't been using Picamilon for years. But I have been on some kind of GABA enhancing med for all of this time, whether it is Klonopin, Lyrica, Phenibut, etc.
I wonder what percentage of people with Social Phobia (which I believe has a strong GABA component) also have insomnia
> Darn!! I just knew it!
>
> See below.
>
> Maria
>
> -0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-
>
> Adults with primary insomnia have a specific neurochemical imbalance that makes it more difficult for their brains to settle down for sleep, a new study says.
>
> People with primary insomnia for more than six months have 30 percent less gamma-aminobutyric acid (GABA), a chemical that slows overall activity in many brain areas, according to the report in the Nov. 1 issue of Sleep. A "racing mind" and an inability to shut down at night is a common complaint of people with primary insomnia.
>
> "GABA is reduced in the brain of individuals with insomnia, suggesting overactivity is present not only at the level of excessive thoughts and emotions, but can also be detected at the level of the nervous system," principal investigator John Winkelman of Brigham and Women's Hospital, in Boston, said in an American Academy of Sleep Medicine news release.
>
> While most insomnia occurs in conjunction with another illness or disorder, either physical or mental, or as a side effect of certain medications or substances, primary insomnia occurs without a coexisting condition. Approximately a quarter of people with insomnia suffer from this particular type of the sleep disorder.
>
> The finding suggests that primary insomnia is a manifestation of hyperarousal, a neurobiological state, that Winkelman said helps validate an often misunderstood complaint of insomnia.
>
> "Recognition that insomnia has manifestations in the brain may increase the legitimacy of those who have insomnia and report substantial daytime consequences," he said. "Insomnia is not just a phenomenon observed at night, but has daytime consequences for energy, concentration and mood."
>
> Lower brain GABA levels also have been found in people with major depressive disorder (MDD) and anxiety disorders. As primary insomnia is a critical risk factor in these conditions, the findings could mean GABA deficiencies seen in people with mood and anxiety disorders may be tied to sleep disturbances.
>
> Many of the hypnotic medications most effective in treating insomnia are benzodiazepine receptor antagonists (BzRAs), which increase activity at the GABA neurons, the study also reported.
>
> Please follow the link to read more:
> www.life-extension-drugs.com/
>
> Primary Insomnia Tied to Brain Neurochemical Imbalance (news from life-extension-drugs.com)‏
> From: life-extension-drugs.com
> _________________________
>
> Primary Insomnia Tied to Brain Neurochemical Imbalance
> Finding suggests complaint of a 'racing mind' is not just in patient's head
> www.life-extension-drugs.com/
> _________________________
>
Posted by mav27 on November 21, 2008, at 10:42:09
In reply to Re: Insomnia and Social Phobia » Maria3667, posted by Michael Bell on November 21, 2008, at 9:01:56
>
> I wonder what percentage of people with Social Phobia (which I believe has a strong GABA component) also have insomnia
>
>Well it's 3:41am here and yet again i can't sleep for the life of me... so i can certainly say i'm one of the people with social phobia and insomnia.
Posted by paxvox59 on November 21, 2008, at 15:00:54
In reply to Insomnia Tied to Brain Neurochemical Imbalance, posted by Maria3667 on November 19, 2008, at 15:27:01
Well, I guess that figures. For years, the only thing that allowed me to get decent sleep were the Benzos. However, most docs don't LIKE to give out Benzos because they addictive! So, I have to ask, "what's worse, not sleeping worth crap for years and having EVERY aspect of life affected adversely, or being reliant upon a medication that allows one to sleep?" For me, it's a no-brainer, but just try to find a doc who agrees!
PAX
Posted by Phillipa on November 21, 2008, at 18:39:01
In reply to Re: Insomnia Tied to Brain Neurochemical Imbalance, posted by paxvox59 on November 21, 2008, at 15:00:54
I have one thank-fully. Phillipa
This is the end of the thread.
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