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Dr. Bob is Robert Hsiung, MD,
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Posted by Medline on October 29, 2008, at 8:49:09
My psychiatrist suggested that I start Tranylcypromine treatment. I read that taking noradrenergic TCAs or NARIs and then slowly adding Tranylcypromine is not just safe, but also reduces the likelihod of tyramine-induced hypertension.
Reason (psychotropical.com/maois_full.shtml):
This is because the cheese reaction (potentially catastrophic hypertension) requires that the provoking dietary component (the amino acid tyramine) must first enter the pre-synaptic nerve, from whence it displaces noradrenaline which then mediates the hypertension. Tyramine is actively moved into the pre-synaptic nerve by the very same reuptake mechanism that is blocked by TCAs, which are NRIs.
I also read this on the german website of the manufacturer of Tranylcypromine (Jatrosom.de).
http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20080926/msgs/854483.html
http://www.ncbi.nlm.nih.gov/pubmed/7931221
Would you prefer this strategy? My second question is what do you think about adding 50 mg Amisulpride to a MAOI. It is supposed to work as a dopamine releaser in this dose. Any experiences?
Posted by mav27 on October 29, 2008, at 10:36:39
In reply to MAOI + Reboxetine + Amisulpride?, posted by Medline on October 29, 2008, at 8:49:09
You'll be bouncing around the room like a speed addict lol. I have tried parnate with both those things... amisulpride didn't seem to have any reation with it. Reboxetine when combined with the parnate gave me a really bad hypotensive episode though.
This is the end of the thread.
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