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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by bleauberry on October 19, 2008, at 14:01:56
We have seen many reports of generics causing different side effects, relapses, or non-response over recent years. While the active ingredient is supposedly the same, fillers could be suspect of interfering with how the active ingredient works. A prime example is new-Nardil versus original-Nardil.
Low Dose Naltrexone seems to be a popular new discovery for many diseases. Here is a discussion about fillers. It is just one of many examples I have seen. In this example, a filler of calcium carbonate (seems innocent, yeah?) is bad news because it changes the absorption rate of Naltrexone. Glucose or lactose fillers are preferred.
Who knows what any of the other fillers out there do? Nobody. The pharmaceutical science gods assume they are neutral agents, but that may not be the case, as this one example illustrates. The Low Dose Naltrexone doctors also strongly advice to stay away from certain fillers.....
Patient Discussion Quote: "Myself, as a MS patient, playing around with fillers at the 3rd month into LDN I switched from Lactose filler to Calcium Carbonate filler. HUGE MISTAKE, the CC made LDN to become sustained release/slow release, a major problem as LDN needs to be fast release or the LDN is worthless in your system. CC does not do this to LDN every time it is made up but it can at any time cause LDN to release slow so I warn everyone to please stay clear of any pharmacist who uses Calcium Carbonate in the LDN capsules.
During my 3rd month on LDN in my switching my filler from Lactose to Calcium Carbonate I noticed within the first 5 days my MS symptoms starting to return. I immediately called my pharmacist and she mixed up a new batch with Lactose and I took that and all went back to great again and has continued to be great since then and I've been on 4.5mg of LDN 4 years now(2007) and have had absolutely no disease progression.
This sort of disaster could cost a cancer patient his/her life, so BEWARE Cancer patients, stay clear of Calcium Carbonate as your capsule filler. Be firm in this with your pharmacist and tell him/her why you fear CC. I'm not the only person this has happened to. Fast release fillers that are good are Lactose, Acidophilus(non-dairy/Non-refrigerate), Gelatin, Avicel-a.k.a. Cellulose(if allergic can cause headache, nausea, vomiting). Dr. Bihari preferred Lactose filler over all fillers but if you're allergic request acidophilus or gelatin.
Cornstarch has been used but many get sick to their stomachs on cornstarch filler.
I still keep my mom away from Calcium Carbonate filler since she has had cancer.
I pray no one else has failure of LDN because of Calcium Carbonate filler. The way I felt on Lactose filler compared to Calcium Carbonate filler was way too obvious. The Calcium Carbonate literally made the LDN worthless(not work) in my body. CC was like taking a placebo and when I switched back to Lactose I started to see positive results."
Just something to ponder when wondering about the quality of generics. Some people do great on them, some don't. In a worst case scenario, generics actually have the potential to kill people, if the drug doesn't work and they commit suicide, or if their disease progresses.
Fillers matter. Exactly how, time will tell. For now, there is enough evidence to at least be aware that the active ingredient in a generic pill is not the whole story. The other filler ingredients are not necessarily neutral.
Posted by Phillipa on October 19, 2008, at 19:55:20
In reply to Generics Not The Same, posted by bleauberry on October 19, 2008, at 14:01:56
But you really don't have MS right? Was only an example? I know they are not the same. Phillipa
This is the end of the thread.
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