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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by FrequentFryer on August 22, 2008, at 6:50:12
Hi All.
What is Poop-Out exactly???
Some say Anti-D's have a stimulating effect at first. (Maybe this is poop out)
My Doc says its because after a while you tend to take the elevated serotonin for granted or something like that.
To me it just seems like tollerance.
Nardil and Effexor work well for me for about a month but then I am no better off then when I am drug free.
What I would like to know though is if anyone here has beaten poop out and how they did it. Probably allot of people here who would like to know that.
Also (for the smart people). Dose science understand what exactly tollerance is? The only drugs I know of that you don't (supposedly) get a tollerance to are Antidepressants and Antipsychotics... Dose anyone know why?
Posted by Jeroen on August 22, 2008, at 9:44:32
In reply to Advanced Poop-Out Discussion, posted by FrequentFryer on August 22, 2008, at 6:50:12
hi, its worth a try atleast im going to do this
you have 2 option but i recommend the memantine 30 mg one because it can be that one has been studied. note both are medicine against alzheimerOPTION 1
memantine... the nmda antagonist, that has been theorized to reverse or hold off tolerance to psychostimulants. It has been working brilliantly for two full months, in combination with modafinil and a fairly steady intake of caffeine...
OPTION 2:
As others have noticed, tolerance develops. It's my experience that selegiline helps reverse it, and that after approximately a week of selegiline (10 mg/day p.o.) abstinence from dopamine autoreceptor antagonists, a prominent stimulant response is again possible upon resuming the antagonist.
Posted by Phillipa on August 22, 2008, at 12:04:36
In reply to Advanced Poop-Out Discussion, posted by FrequentFryer on August 22, 2008, at 6:50:12
Good question and obviously I'm not a smart person here just average and to me poop out is when a drug no longer works. I guess the brain adapts and it's no longer effective. As to tolerance in a way is it the same thing kind of worded differently? As in both cases what once worked no longer does???? Phillipa
Posted by Jeroen on August 22, 2008, at 12:20:32
In reply to Re: Advanced Poop-Out Discussion » FrequentFryer, posted by Phillipa on August 22, 2008, at 12:04:36
read my post philippa, i know someone who took prozac and it didnt worked anymore, he took a risk taking memantine and it start working again miraculously
i found other with simular experiences, i am going to give this a try, but on the other hand i have psychosis i need to be very carefull with this
Posted by Phillipa on August 22, 2008, at 13:32:41
In reply to Re: Advanced Poop-Out Discussion, posted by Jeroen on August 22, 2008, at 12:20:32
Jeroen yes and I did and you have your pdoc there to guide you and help right? Phillipa
Posted by Jeroen on August 22, 2008, at 13:56:11
In reply to Re: Advanced Poop-Out Discussion » Jeroen, posted by Phillipa on August 22, 2008, at 13:32:41
yes
Posted by Phillipa on August 22, 2008, at 20:03:18
In reply to Re: Advanced Poop-Out Discussion, posted by Jeroen on August 22, 2008, at 12:20:32
Jeroen yes I agree. Phillipa
Posted by Justherself54 on August 22, 2008, at 20:25:55
In reply to Advanced Poop-Out Discussion, posted by FrequentFryer on August 22, 2008, at 6:50:12
> Hi All.
> What is Poop-Out exactly???
> Some say Anti-D's have a stimulating effect at first. (Maybe this is poop out)
> My Doc says its because after a while you tend to take the elevated serotonin for granted or something like that.
> To me it just seems like tollerance.
> Nardil and Effexor work well for me for about a month but then I am no better off then when I am drug free.
> What I would like to know though is if anyone here has beaten poop out and how they did it. Probably allot of people here who would like to know that.
> Also (for the smart people). Dose science understand what exactly tollerance is? The only drugs I know of that you don't (supposedly) get a tollerance to are Antidepressants and Antipsychotics... Dose anyone know why?I don't know and I wish I did, as it keeps happening to me. I'll get a good response and then 6 mos later, maybe a year if I'm lucky they poop out (stop working). I read somewhere (can't remember what website I was on) that AD's are designed for short term i.e. one year use and that is a problem they are facing for people who need to be on them for long periods of time.
Hopefully someone with some scientific knowledge will pop into this thread and explain (although I get kind of lost when it comes to the gargon).
Posted by aussie_jon on August 22, 2008, at 22:54:41
In reply to Re: Advanced Poop-Out Discussion » FrequentFryer, posted by Phillipa on August 22, 2008, at 12:04:36
It could be the brain addapting to the drug, it could be the body handeling the drug diferently, or it could be the bar getting raised by the patient as they start to feel better.
I would say that if you "poop out" try a dose increase first, and changing to a new drug with a different mode of action, or adding a second drug with a different mode of action to the first, as a second alternative.
Posted by FrequentFryer on August 22, 2008, at 23:54:38
In reply to research, posted by Jeroen on August 22, 2008, at 9:44:32
> hi, its worth a try atleast im going to do this
> you have 2 option but i recommend the memantine 30 mg one because it can be that one has been studied. note both are medicine against alzheimer
>
> OPTION 1
>
> memantine... the nmda antagonist, that has been theorized to reverse or hold off tolerance to psychostimulants. It has been working brilliantly for two full months, in combination with modafinil and a fairly steady intake of caffeine...
>
>
> OPTION 2:
> As others have noticed, tolerance develops. It's my experience that selegiline helps reverse it, and that after approximately a week of selegiline (10 mg/day p.o.) abstinence from dopamine autoreceptor antagonists, a prominent stimulant response is again possible upon resuming the antagonist.
>
>
>
>Thanks for that.. I have read that NMDA antagonists prevent tollerance and Memantine can be used to potentiate a number of drugs and prevent (or even reverse) alcohol, cocaine, opiate, and amphetamine tolerance.
It dosn't seem to interact with many other drugs either. But I dont know if it would help an MAOI or SSRI.
What drugs are you going to supplement it with?
D-Amphetamine used to fix all my problems but recently it just gives me insomnia.
Posted by FrequentFryer on August 23, 2008, at 0:04:33
In reply to Re: Advanced Poop-Out Discussion, posted by aussie_jon on August 22, 2008, at 22:54:41
> It could be the brain addapting to the drug, it could be the body handeling the drug diferently, or it could be the bar getting raised by the patient as they start to feel better.
>
> I would say that if you "poop out" try a dose increase first, and changing to a new drug with a different mode of action, or adding a second drug with a different mode of action to the first, as a second alternative.Hi Jon. Im in Australia to. I've tried alot of the above. Memantine sounds like it might be worth a try but being in Australia even if it is available I bet it will be expensive.
Posted by aussie_jon on August 23, 2008, at 3:02:20
In reply to Re: Advanced Poop-Out Discussion » aussie_jon, posted by FrequentFryer on August 23, 2008, at 0:04:33
FF
looks like about $120 per month if you arnt using it for altzheimers
Have you tried Edronax plus Zoloft?
Posted by FrequentFryer on August 23, 2008, at 22:29:53
In reply to Re: Advanced Poop-Out Discussion, posted by aussie_jon on August 23, 2008, at 3:02:20
> FF
>
> looks like about $120 per month if you arnt using it for altzheimers
>
> Have you tried Edronax plus Zoloft?Nope. I have been on Zoloft alone for the last few months mainly because it's the only one that dosn't make me extremly constipated but I have decided to stop it (unless you have had similar experiences to me and liked Edronax with Zoloft) to try high dose Selegiline. (Low dose did nothing).
What's your experience with Zoloft and Edronax?
Posted by Zyprexa on August 31, 2008, at 22:43:15
In reply to Re: Advanced Poop-Out Discussion » FrequentFryer, posted by Phillipa on August 22, 2008, at 12:04:36
I've been taking Celexa for about 7 years, and just had to switch to zoloft, because the celexa seemed like it was not doing anything any more.
It does seem like the zoloft works beter than the celexa was. I've been off the celexa for 4 days now, and I don't seem to miss it at all. It was like I stoped taking nothing?
Posted by aussie_jon on August 31, 2008, at 23:57:04
In reply to Re: Advanced Poop-Out Discussion, posted by Zyprexa on August 31, 2008, at 22:43:15
I found adding Edronax (4mg twice a day) to my Zoloft was amazing, within about 4 days, the fog began to lift, and I felt the old me comming back.... it was great.
Might be worth asking your doc for a months trial?
Posted by FrequentFryer on September 1, 2008, at 22:29:14
In reply to Re: Advanced Poop-Out Discussion, posted by Zyprexa on August 31, 2008, at 22:43:15
> I've been taking Celexa for about 7 years, and just had to switch to zoloft, because the celexa seemed like it was not doing anything any more.
>
> It does seem like the zoloft works beter than the celexa was. I've been off the celexa for 4 days now, and I don't seem to miss it at all. It was like I stoped taking nothing?It will probably take a couple of weeks before the Celexa has completly washed out. And it will take a couple of weeks before the Zoloft completly washes in.
Posted by FrequentFryer on September 1, 2008, at 22:35:31
In reply to Re: Advanced Poop-Out Discussion, posted by aussie_jon on August 31, 2008, at 23:57:04
> I found adding Edronax (4mg twice a day) to my Zoloft was amazing, within about 4 days, the fog began to lift, and I felt the old me comming back.... it was great.
>
> Might be worth asking your doc for a months trial?Damn I probably would have tried that,, might next time. I am taking Nardil again now. It will make me 10 foot tall and bulletproof for about a month but I'm not sure what I will do after that.
This is the end of the thread.
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