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Dr. Bob is Robert Hsiung, MD,
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Posted by qbsbrown on August 19, 2008, at 10:39:18
I know that one block dopamine, while the other increases it. I have BP II and ADAD inattentive. Unfortunately all the BP meds make my ADD worse to the point I can't work.
I wonder if ritalin and provigil could overcome depakote and seroquel?
Thanks,
Brian
Posted by med_empowered on August 19, 2008, at 12:18:01
In reply to Do Antipsychotics negate/trump stimulants?, posted by qbsbrown on August 19, 2008, at 10:39:18
Combining antipsychotics+stimulants is actually relatively common. Although antipsychotics (especially old, high-potency ones like Haldol) can negate stimulants' effects (so much so that Haldol is used for amphetamine psychosis), the effect really depends on the drug used and the dosages.
For instance: back in the day,there were bunches of low-dose antipsychotic+amphetamine combo pills, such as Eskatrol (prochlorperazine+dexedrine) and ThoraDex (thorazine plus dexedrine). Some docs use Ritalin to overcome sedation from Clozapine or seroquel. Provigil is being used a whole lot with antipsychotics, too.
Sooo...I'd say the combo can be worked out, but its kind of tricky to get the right amount of stimulation (w/o agitation) and the right amount of mood stabilization (w/o sedation or apathy). Plus, if I remember correctly, using amphetamines with antipsychotics might increase the risk of TD over the long haul.Good luck.
Posted by bleauberry on August 19, 2008, at 15:41:55
In reply to Do Antipsychotics negate/trump stimulants?, posted by qbsbrown on August 19, 2008, at 10:39:18
When I was on zyprexa it did not seem to block the effects of ritalin. It also did not block the effects of adrafinil or modafinil. It may have smoothed them out a little bit, but by no means negated them.
There are numerous regions of the brain and all these meds increase or decrease a certain neurotransmitter function in specific areas of the brain, but not usually equally universally throughout. It is not as simple as saying one thing blocks dopamine while another increases it.
This is the end of the thread.
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