![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by Marty on July 30, 2008, at 22:50:56
I thought you would be interested:The most promising next gen Alzheimer med yet is called "Rember", now in phase 2. Rember active molecule is methylthioninium chloride, also known as methylene blue. What is interesting is that it's a potent MAOI (reversible..... ) which has being described lately (2007) as being a highly potent/selective MAO-A inhibitor with antidepressant properties. With the current results in phase II it may well become the most prescribed selective MAO-A inhibitor in the next decade:
"The people on placebo lost an average of 7 percent of their brain function over six months whereas those on treatment didnt decline at all.
After about a year, the placebo group had continued to decline but those on the mid-level dose of Rember had not. At 19 months, the treated group still had not declined as Alzheimers patients have been known to do."From a 2 days old article at http://www.msnbc.msn.com/id/25918231/
The effect of Rember on Alzheimer isn't related to his MAOI properties. I only wish they would develop (if possible) a patch version.. which I doubt.I guess we would have to call this one "The Smurf Patch" ;)
Some new studies about MB as a MAO-A inhibitor:
http://www.ncbi.nlm.nih.gov/pubmed/18077577?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed
I've read that the formulation include MB but it suggest it may have something else... I wonder if it's something that somehow reduce MB MAOI properties./\/\arty
Posted by SLS on August 2, 2008, at 7:33:01
In reply to SLS: This may interest you, posted by Marty on July 30, 2008, at 22:50:56
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.