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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by undopaminergic on July 4, 2008, at 8:32:55
There are many interesting substances with antidepressant- or stimulant-like effects, some of which may at some point be introduced for clinical use, some of which will remain tools for research exclusively, and some of which will find little use at all.
For the more adventurous amongst us, some of these substances may be interesting to test.
Anyone doing anything along these lines?
Posted by dbc on July 4, 2008, at 11:25:49
In reply to Research chemicals - anyone using them?, posted by undopaminergic on July 4, 2008, at 8:32:55
Friends and my friend SWIM has quite a bit of experience with the tryptamines. SWIM is not a fan of being a guinea pig but once ingested some DOB beliving it to be something else and was not at all pleased with 18 hours of patterned walls and shape shifting shadows, all the usual stuff you would expect.
Shulgin's research was great and quite ballsy of him to say the least but im not sure if the common man should be taking some of these things. The average person shouldnt have access to substances like 2c-i that at 5mg can send you into a mind blowing 8 hour trip.
That whole scene seems to have shifted from tryptamines to stimulant alternatives as of recently since the analogue act really isnt being enforced. Unfortunately this may lead to the gray area of these substances to become much less gray in the eyes of johnny law. College students tripping out on synthetic psyilocybin is a little different than novel stimulant junkies.
Posted by undopaminergic on July 4, 2008, at 14:18:51
In reply to Re: Research chemicals - anyone using them?, posted by dbc on July 4, 2008, at 11:25:49
> Friends and my friend SWIM has quite a bit of experience with the tryptamines. SWIM is not a fan of being a guinea pig but once ingested some DOB beliving it to be something else and was not at all pleased with 18 hours of patterned walls and shape shifting shadows, all the usual stuff you would expect.
>
> Shulgin's research was great and quite ballsy of him to say the least but im not sure if the common man should be taking some of these things. The average person shouldnt have access to substances like 2c-i that at 5mg can send you into a mind blowing 8 hour trip.
>
> That whole scene seems to have shifted from tryptamines to stimulant alternatives as of recently since the analogue act really isnt being enforced. Unfortunately this may lead to the gray area of these substances to become much less gray in the eyes of johnny law. College students tripping out on synthetic psyilocybin is a little different than novel stimulant junkies.
>Anything that becomes popular among sufficiently large masses of people will be banned, that's for certain. However, the stimulant-alternatives (e.g. MDPV - methylenedioxypyrovalerone) don't seem to be enjoying such popularity yet.
Of course, my intention wasn't to enquire about alternative recreational substances, but about novel therapeutic agents, for example, research compounds of use in depression or anxiety. Agomelatine would qualify, and other serotonin 5-HT2C-antagonists even more so. Long-acting kappa-opioid receptor antagonists such as nor-binaltorphimine might be another example.
Posted by dbc on July 4, 2008, at 14:27:36
In reply to Re: Research chemicals - anyone using them?, posted by undopaminergic on July 4, 2008, at 14:18:51
Right, im unfamiliar with more therapeutic substances. When i saw "research chemicals" one thing came to mind.
Posted by bulldog2 on July 4, 2008, at 14:56:58
In reply to Research chemicals - anyone using them?, posted by undopaminergic on July 4, 2008, at 8:32:55
> There are many interesting substances with antidepressant- or stimulant-like effects, some of which may at some point be introduced for clinical use, some of which will remain tools for research exclusively, and some of which will find little use at all.
>
> For the more adventurous amongst us, some of these substances may be interesting to test.
>
> Anyone doing anything along these lines?
>Tried pt-141. Seemed to work well.
Posted by bleauberry on July 5, 2008, at 19:44:02
In reply to Research chemicals - anyone using them?, posted by undopaminergic on July 4, 2008, at 8:32:55
The only research chemical I've ever used was cannibas. :-) They need to speed up the research. I believe there are amazing molecules in that stuff that could be isolated for specific treatments.
Haven't had any in three years, but it was quite an effective research experiment for me until it got too risky.
Posted by SLS on July 6, 2008, at 5:36:12
In reply to Re: Research chemicals - anyone using them?, posted by bleauberry on July 5, 2008, at 19:44:02
clorgyline
indalpine
viqualine
RU-8059
bupropion (as an investigational in 1983)
idazoxan
adinazolam
nomifensine (prior to approval in 1985)
ET-495 (piribedil prior to approval)
mifepristone
riluzole
sibutramineI may be forgetting a few. I think the last three qualify as research chemicals for depression, although they are now approved for other indications.
I have not tried these drugs that have been marketed:tianeptine
amineptine
maprotiline
viloxazine
adrafinil
doxepin
toloxatone
dothiepin
clozapineThat's all I can think of at the moment. It's a pretty short list.
- Scott
This is the end of the thread.
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