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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by iforgotmypassword on June 17, 2008, at 7:46:15
(and in my case this would be selegiline, now 10mg, probably going to be 15mg.)
is this more sweeping unsupported garbage that you see in nearly every insert?
or is there actually a mechanism or neurochemical change to worry about?
Posted by SLS on June 17, 2008, at 12:50:58
In reply to tianeptine cannot be mixed with maoi?, posted by iforgotmypassword on June 17, 2008, at 7:46:15
> (and in my case this would be selegiline, now 10mg, probably going to be 15mg.)
>
> is this more sweeping unsupported garbage that you see in nearly every insert?
>
> or is there actually a mechanism or neurochemical change to worry about?
See:http://www.dr-bob.org/babble/20080617/msgs/835062.html
- Scott
Posted by Sigismund on June 17, 2008, at 15:14:30
In reply to Re: tianeptine cannot be mixed with maoi?, posted by SLS on June 17, 2008, at 12:50:58
I was taking 3 tianeptines a day and thought it might be a good idea to take a Parnate as well.
I felt very bad and went to bed for the day, though what exactly that had to do with I don't know.
I took low dose deprenyl (1mg/d) with tianeptine with no ill effect apart from possible aggravation of insomnia.
Posted by iforgotmypassword on June 17, 2008, at 16:54:25
In reply to Re: tianeptine cannot be mixed with maoi?, posted by SLS on June 17, 2008, at 12:50:58
thanks for that. i wish i understood it all better. i had some theoretically stuff i wanted to share earlier. i am having a lot of trouble posting it. god it's been days and the threads keep receding and receding back and back up into the top. i have to get with it, force it out of me. :-(
but anyway. i'm not on topic.
for selegiline 10mg and 15mg (15mg is presumably still MAO-B specific, i would be taking 7.5mg 2x day i think):
the reduction being mao-b specific should not cause issue over a serotonin increase no matter where it is, is this correct?
unrelated, when you say more serotonin near presynaptic terminals, this is still anti-serotonergic in it's EFFECT right?
Posted by SLS on June 17, 2008, at 17:09:32
In reply to regarding selegiline » SLS, posted by iforgotmypassword on June 17, 2008, at 16:54:25
> thanks for that. i wish i understood it all better. i had some theoretically stuff i wanted to share earlier. i am having a lot of trouble posting it. god it's been days and the threads keep receding and receding back and back up into the top. i have to get with it, force it out of me. :-(
>
> but anyway. i'm not on topic.
>
> for selegiline 10mg and 15mg (15mg is presumably still MAO-B specific, i would be taking 7.5mg 2x day i think):
>
> the reduction being mao-b specific should not cause issue over a serotonin increase no matter where it is, is this correct?
>
> unrelated, when you say more serotonin near presynaptic terminals, this is still anti-serotonergic in it's EFFECT right?It may possible that the net effect of tianeptine is to enhance serotoninergic neurotransmission. So this would be pro-serotoninergic. Remember, this is only my own conjecture, and may not accurately portray what is actually going on.
Forget our silly little theories for the moment. You are really just performing an experiment. Unless you have found instances otherwise, you must regard this combination as an experiment that has never been performed before. What precautions would you take in the absence of safety data?
- Scott
Posted by linkadge on June 17, 2008, at 17:47:13
In reply to Re: regarding selegiline » iforgotmypassword, posted by SLS on June 17, 2008, at 17:09:32
I am correct in saying that the serotonin transporter transports serotonin back into the cell where is is metabolized by MAO?
If you acellerate the tranporter but block MAO it would result in elevated levels of serotonin in the cell...the significance of that I do not know.
Linkadge
Posted by SLS on June 17, 2008, at 18:21:56
In reply to Re: regarding selegiline, posted by linkadge on June 17, 2008, at 17:47:13
> I am correct in saying that the serotonin transporter transports serotonin back into the cell where is is metabolized by MAO?
One variable to increasing the amount of neurotransmitter is its sequestration within synaptic vessicles to protect it from cytoplasmic MAO.
- Scott
This is the end of the thread.
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