![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by garylee on May 17, 2008, at 13:04:16
Scott, and anyother readers...
I want to ask if you have any experience with labs/chemical company's synthesising meds for the public..?
The Amineptine guy I am speaking to say's he has his synthesised as the only company in Brazil that was manufacturing eventually stopped production, so I know it is possible somehow.
The med I am interested is called 'Dinapsoline' it is a direct D1 agonist. The company's website is:
http://www.axonmedchem.com/product/1124dinapsolineS.html
I'm having trouble finding much research of the med being used on humans but have found some.
So anyone with any ideas, costs etc?
Thanks
Gary
Posted by SLS on May 17, 2008, at 13:29:28
In reply to For SLS - But ALL PLEASE READ! :O), posted by garylee on May 17, 2008, at 13:04:16
> Scott, and anyother readers...
Dinapsoline is an interesting drug. I guess the only thing I would be concerned with is sudden sedation / sleep attacks similar to what apomorphine is known to produce at low dosages.
I am VERY curious how you became interested in D1 agonism.
- Scott
Posted by garylee on May 17, 2008, at 16:08:56
In reply to Re: For SLS - But ALL PLEASE READ! :O) » garylee, posted by SLS on May 17, 2008, at 13:29:28
> > Scott, and anyother readers...
>
> Dinapsoline is an interesting drug. I guess the only thing I would be concerned with is sudden sedation / sleep attacks similar to what apomorphine is known to produce at low dosages.
>
> I am VERY curious how you became interested in D1 agonism.
>
>
> - Scott
>Hey Scott
Well, (remember this all my armchair pharmacology, which why I ask you! lol) I'm led to believe that Cocaine works as an agonist mainly on the D1 receptor (though I think it's also some sort of SDRI), Cocaine is the only drug that really helps my depression, anxiety, SP, depersonalization/derealization, etc, etc... This all how my hunt for Dopamine meds came about. For a long time I was hunting for Amineptine, the only real SDRI ever made (FDA bans all drugs that make you feel good...f**kers!).I had your personal email addy around 2002, we were speaking for a while, but I think you were a bit worse than you are now and we lost contact. We spoke about Amineptine at great length, amongst other things.
Anyhoo, that's the story behind my Dopamine quest. But going back to the original question have you any knowledge on lab synthesis? Also you knew of Dinapsoline. Is it available anywhere?
Awaiting your wise reply :O)
Thanks
Gary
Posted by garylee on May 17, 2008, at 16:20:10
In reply to Re: For SLS - But ALL PLEASE READ! :O), posted by garylee on May 17, 2008, at 16:08:56
SCott
You may want to look at this, an interesting read...
http://www.cocaine.org/dopamine/d1.html
Gary
Posted by SLS on May 17, 2008, at 16:24:18
In reply to Re: For SLS - But ALL PLEASE READ! :O), posted by garylee on May 17, 2008, at 16:08:56
> > Dinapsoline is an interesting drug. I guess the only thing I would be concerned with is sudden sedation / sleep attacks similar to what apomorphine is known to produce at low dosages.
> >
> > I am VERY curious how you became interested in D1 agonism.
> Well, (remember this all my armchair pharmacology, which why I ask you! lol) I'm led to believe that Cocaine works as an agonist mainly on the D1 receptor (though I think it's also some sort of SDRI), Cocaine is the only drug that really helps my depression, anxiety, SP, depersonalization/derealization, etc, etc... This all how my hunt for Dopamine meds came about. For a long time I was hunting for Amineptine, the only real SDRI ever made (FDA bans all drugs that make you feel good...f**kers!).I had your personal email addy around 2002, we were speaking for a while, but I think you were a bit worse than you are now and we lost contact. We spoke about Amineptine at great length, amongst other things.
>
> Anyhoo, that's the story behind my Dopamine quest. But going back to the original question have you any knowledge on lab synthesis? Also you knew of Dinapsoline. Is it available anywhere?You know, cocaine is also a norepinephrine AND serotonin reuptake inhibitor. It would be difficult to know how to interpret your improvement reaction to cocaine. What does methylphenidate do for you? Have you ever combined with a serotonin reuptake inhibitor? I'll try to look into D1 receptors. Just know that Mirapex exerts its effects in the limbic system via D3 receptors, those involved with mood and reward.
Sorry, gotta' run now. If I come up with anything, I'll let you know.
> Awaiting your wise reply :O)
Well, I figured you wouldn't want to wait for me to come up with a wise reply, so I gave you this one instead.
Take care.
- Scott
Posted by garylee on May 17, 2008, at 16:35:30
In reply to Re: For SLS - But ALL PLEASE READ! :O), posted by SLS on May 17, 2008, at 16:24:18
You know, cocaine is also a norepinephrine AND serotonin reuptake inhibitor. It would be difficult to know how to interpret your improvement reaction to cocaine. What does methylphenidate do for you? Have you ever combined with a serotonin reuptake inhibitor? I'll try to look into D1 receptors. Just know that Mirapex exerts its effects in the limbic system via D3 receptors, those involved with mood and reward.
>
> Sorry, gotta' run now. If I come up with anything, I'll let you know.
>
> > Awaiting your wise reply :O)
>
> Well, I figured you wouldn't want to wait for me to come up with a wise reply, so I gave you this one instead.
>
> Take care.
>
>
> - ScottYes I was aware of Cocaines norepinephrine and serotonin reuptake inhibitor properties, I think that it's very much more focused on Dopamine though, the reward chemical as they say, hence the massive addiction potential.
Never heard of methylphenidate? I will check it google now (thanks!). Unfortunatly ALL Serotonin reuptake inhibitors make me hypomanic (hence the Bipolar diagnosis) so they are probably out of the question. As it goes, Prozac, the first SSRI I took started my rapid cycling back in 2001...
Hope you have a good time where ever you go tonight Scott.
Gary
Posted by garylee on May 17, 2008, at 16:37:27
In reply to Re: For SLS - But ALL PLEASE READ! :O), posted by garylee on May 17, 2008, at 16:35:30
> You know, cocaine is also a norepinephrine AND serotonin reuptake inhibitor. It would be difficult to know how to interpret your improvement reaction to cocaine. What does methylphenidate do for you? Have you ever combined with a serotonin reuptake inhibitor? I'll try to look into D1 receptors. Just know that Mirapex exerts its effects in the limbic system via D3 receptors, those involved with mood and reward.
> >
> > Sorry, gotta' run now. If I come up with anything, I'll let you know.
> >
> > > Awaiting your wise reply :O)
> >
> > Well, I figured you wouldn't want to wait for me to come up with a wise reply, so I gave you this one instead.
> >
> > Take care.
> >
> >
> > - Scott
>
> Yes I was aware of Cocaines norepinephrine and serotonin reuptake inhibitor properties, I think that it's very much more focused on Dopamine though, the reward chemical as they say, hence the massive addiction potential.
>
> Never heard of methylphenidate? I will check it google now (thanks!). Unfortunatly ALL Serotonin reuptake inhibitors make me hypomanic (hence the Bipolar diagnosis) so they are probably out of the question. As it goes, Prozac, the first SSRI I took started my rapid cycling back in 2001...
>
> Hope you have a good time where ever you go tonight Scott.
>
> GaryAaaahhh... Ritalin. Didn't know its generic name! lol
Posted by garylee on May 19, 2008, at 17:36:24
In reply to Re: For SLS - But ALL PLEASE READ! :O), posted by garylee on May 17, 2008, at 16:37:27
Scott
Any joy with any D1 research..? Lol, hopefully not asking too much of you! ;O)
Gary
Posted by SLS on May 19, 2008, at 20:21:41
In reply to Re: For SLS - But ALL PLEASE READ! :O), posted by garylee on May 19, 2008, at 17:36:24
> Scott
>
> Any joy with any D1 research..? Lol, hopefully not asking too much of you! ;O)
>
> GaryNot yet. I had a busy weekend, and, for reasons unbeknownst to me, had sleep attacks all day today.
- Scott
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.