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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 19 of 19. This is the beginning of the thread.
Posted by JDx on April 13, 2008, at 17:48:41
hi all,
(sorry for my english in advance)
I have been taking ritalin for a few years,for ADHD. and A few month ago went to a doctor mainly because i felt depression, anxiety,blunt effect. after a series of tests in the mental hospital he works in, they concoluded that I have a little bit of all the mental problems..and told me that i don't have excaly adhd and he thinks i have little bit of schizophrenia. actually he were not really sure:/
nevertheless he prescribed me Respirdone..told me that the only sideeffect will be sedetion. after a few days i noticed that i can't think ,rememeber, concentrate..and felt practicly like a retard and also felt depressed from it....so I told that to him, and he gave me serqual instead. serqual at first seemmed better but only after few days it also made me depressed and stuipd. both drugs made want to kill my self.
so i sugested solian instead..at very low doses (12.5-25) it was tolarable, it diminshed partly my anxiety, made me realy friendly, talkative, and really mentally stable. but my doctor said i need much more dose. So got up to 100 per day. It took me some time to get used the way of thinking with it, but i learnt how live with this high dose. But even though this solian is making me dumb.
a few month ago i started taking 5-HTP with the solian and ritalin (and zinc),it improved my cognitive abilitys abit , though still my memroy is really impaired. I also take creatine to boost my memory , and it also helps aa bit.
Soon i am going to try taking megadose of glycine, mybe it will help, and also i will try dhea - both showed to help schiphrenia cognitve and negative simptoms in clinical trials
Does anyone had experience this problem with solian? My short term memory and my short term visoul memory completly diminished using it. other antipsychotics f*ck*d my cognitive in other ways.
thanks you all for any help or sugestions
jd
Posted by Phillipa on April 13, 2008, at 19:47:20
In reply to cognitive problems from solian, posted by JDx on April 13, 2008, at 17:48:41
Hi Welcome to babble. I myself have no info but I hope someone from your country or who knows the meds answers soon. Love Phillipa
Posted by Quintal on April 13, 2008, at 20:26:32
In reply to cognitive problems from solian, posted by JDx on April 13, 2008, at 17:48:41
That's why I hate antipsychotics. There's a load more side effects with risperidone than sedation, and your pdoc knows it too. I don't like that kind of dishonesty in doctors. As far as cognitive impairment goes, Solian is probably the 'cleanest' of all antispychotics. Actually at low doses it doesn't really act like an antipsychotic at all - it almost has the opposite effect. I was on 200mg in hospital, and lately I've been taking 50mg as required when I need a mood boost, but I haven't noticed much cognitive impairment from it. I doubt 100mg would be doing a great deal for psychosis, so could you either lower the dose or come off it?
Q
Posted by Racer on April 13, 2008, at 23:51:05
In reply to cognitive problems from solian, posted by JDx on April 13, 2008, at 17:48:41
Honestly, my first instinct is to ask if you really do have a psychotic disorder? I assume you've discussed with your doctor his reasons for making that diagnosis? Were his reasons for making the diagnosis compelling to you? Do you believe that you have a schizophrenia-spectrum disorder?
Even if you do believe that that diagnosis is correct, it might still be worth seeing another psychiatrist for a second opinion. Maybe there is something else that might help.
Also, have you discussed all those supplements with your psychiatrist? Many times those supplements can interfere with the actions of psychotropics, which might exacerbate your problems. If you haven't told him about all those supplements, I hope you will.
The bottom line, really, is that you are the one who has to live with the effects of these drugs. If they are causing impairment to your quality of life, then your psychiatrist really should be addressing those problems -- by offering mitigating options, or by changing your medications.
I hope that helps. Your English was quite comprehensible.
Posted by cumulative on April 14, 2008, at 0:20:02
In reply to cognitive problems from solian, posted by JDx on April 13, 2008, at 17:48:41
"he thinks i have little bit of schizophrenia. actually he were not really sure:/"
I suggest lowering your dose if the cognitive effects are intolerable.
While I don't know the details of your situation, I simply cannot, cannot understand the current psychiatric love affair with the antipsychotics.
Posted by JDx on April 14, 2008, at 10:23:43
In reply to Re: cognitive problems from solian » JDx, posted by Phillipa on April 13, 2008, at 19:47:20
> Hi Welcome to babble. I myself have no info but I hope someone from your country or who knows the meds answers soon. Love Phillipa
thank you for the greetings , you are very nice
Posted by JDx on April 14, 2008, at 10:40:37
In reply to Re: cognitive problems from solian » JDx, posted by Quintal on April 13, 2008, at 20:26:32
> That's why I hate antipsychotics. There's a load more side effects with risperidone than sedation, and your pdoc knows it too. I don't like that kind of dishonesty in doctors. As far as cognitive impairment goes, Solian is probably the 'cleanest' of all antispychotics. Actually at low doses it doesn't really act like an antipsychotic at all - it almost has the opposite effect. I was on 200mg in hospital, and lately I've been taking 50mg as required when I need a mood boost, but I haven't noticed much cognitive impairment from it. I doubt 100mg would be doing a great deal for psychosis, so could you either lower the dose or come off it?
>
> QI am pretty sure that solian messes around with my short term memory and visual short term memeory. this side effect happend to me from 25mg and above..and i don't think i am the only one. I read in babble archive that some1 wrote solian made him feel or think 'thin' ..this is how he felt with it, this is how i feel with it. But its exacly the shorter-memroy-feeling.
INMO solian is better then other antipsychotics in the cognitve deficits regard because it doesn't have serotnin antagnoism that makes ADHD like simptomsthe problem that at lower doses of solian i get anxiety thoughts...ie- when i am stopping on red light while driving, i start having anxity thoughts, and afraid that the man in the car behind me will horn me if i will not start driving at the secend it traffic light will become green..
this anti-axiety effect wasn't that good in the previous antipsychotics i tried, so i could get off them..but with solian i can't..
Posted by JDx on April 14, 2008, at 11:17:55
In reply to Re: cognitive problems from solian » JDx, posted by Racer on April 13, 2008, at 23:51:05
> Honestly, my first instinct is to ask if you really do have a psychotic disorder? I assume you've discussed with your doctor his reasons for making that diagnosis? Were his reasons for making the diagnosis compelling to you? Do you believe that you have a schizophrenia-spectrum disorder?
>
> Even if you do believe that that diagnosis is correct, it might still be worth seeing another psychiatrist for a second opinion. Maybe there is something else that might help.
>
> Also, have you discussed all those supplements with your psychiatrist? Many times those supplements can interfere with the actions of psychotropics, which might exacerbate your problems. If you haven't told him about all those supplements, I hope you will.
>
> The bottom line, really, is that you are the one who has to live with the effects of these drugs. If they are causing impairment to your quality of life, then your psychiatrist really should be addressing those problems -- by offering mitigating options, or by changing your medications.
>
> I hope that helps. Your English was quite comprehensible.This what i thought when they told me about his diagnosis . all of the time i was sure i have distymia and ADHD, and the blunt effect was from the ritlain..and when they told me that they think i have schizophrenia at the start, i didn't belive it..
when they 1st prescribed me respirdone they said i will be able to get along without there help, but they suggest that i will try resperidal anyway. I asked if this medcine is like ritalin and can cause dependence like ritalin, so they say the offcourse not. But now i can't get off solian..
anyway, the problem is that before i took antipsychotics i was sure i am not schizophrenic or somthing, but after seeing the changes it made in me and in my qualty of life, i am starting to belive them.
If you are looking from genetics point of view- my father had depression and took antidepression drugs. my mother had pychotic disorder and took for 10 years first genertion antipsychotic , and other family memebers i have , have adhd and depression. so I think that it is possible that i have some kind of schiophrenia.In addition, i am keep saying 'they' thought because 2 doctors and 1 psychologists togther made the daignosis (1 is a beginner psychiatrist and the other was chief psychiatrist at the hospitol). and also another psychologists saw me and made with me personality and wecsler tests.
Also it worth mentioning that 1 of the psychiatris started giving me psychotherapy so he is familier with my problems i am having. But even though, it is possible they are wrong, because they are not specialized in ADHD "spectrum disorders".but you are right though, I should get better solution then this, and better daignosis, so today i sent emailed to my doctor asking him for solution to this cognitive problem and also asked for another daignosis (a few month ago they suggested to give me a panel of tests when i am without any mediction, but after awhile they said it is not necessary so we gave it up)
by the way, they knows about my supplaments, but told me they arnot familiar with them=/
Posted by JDx on April 14, 2008, at 11:24:44
In reply to Re: cognitive problems from solian, posted by cumulative on April 14, 2008, at 0:20:02
> "he thinks i have little bit of schizophrenia. actually he were not really sure:/"
>
> I suggest lowering your dose if the cognitive effects are intolerable.
>
> While I don't know the details of your situation, I simply cannot, cannot understand the current psychiatric love affair with the antipsychotics.I actually don't know what to do, but my life today is much better with solian..sudenly i can make friends, have feelings, understand feelings of another persons, and not suffer from anxiety all day. and i can't stop it because now when i feel how to live more normal with life, low doses of solian are less tolrable
I realy hope that glycine supplament will be as good as solian and i get stop taking it ..i am not sure that my psychiatrist will know how to help me with cognitive problems=[
Posted by Quintal on April 14, 2008, at 13:27:09
In reply to Re: cognitive problems from solian » Quintal, posted by JDx on April 14, 2008, at 10:40:37
Sorry, I wasn't suggesting Solian wasn't messing with your memory, just reporting my own experience. I think it does slow me down slightly - my eyes seem to move more slowly and I feel a little drowsy sometimes, but Zyprexa was so much worse.
The benefits you're feeling from Solian are probably due to the dopamine boosting effect, so maybe you could look at substituting it with something else that boosts dopamine, such as Wellbutrin or Ritalin? I'd think they would be less likely to cause cognitive impairment. I don't know about the glycine, but hopefully something like that will work if your condition is mild. Not everyone that has experienced psychosis needs to be on antipsychotics for life, and there are other ways of treating Schizophrenia.
Q
Posted by undopaminergic on April 15, 2008, at 10:31:59
In reply to cognitive problems from solian, posted by JDx on April 13, 2008, at 17:48:41
Like you, I use methylphenidate (Ritalin, Concerta, etc.) and amisulpride (Solian), but I haven't noticed the memory impairing effect you describe.
One possibility is that amisulpride and methylphenidate potentiate each other too much in some areas of the brain. In particular, the prefrontal cortex is sensitive to excessive dopamine (and noradrenaline) levels. There is evidence that alpha2A-adrenergic agonists are effective for treating such conditions. One such drug - guanfacine - has also proven useful for normalising some cognitive abnormalities in schizotypal personality disorder (a schizophrenia-spectrum disorder). Therefore, guanfacine may be worth a try (it's also good for ADHD).
One study found memantine to be effective for negative (but not cognitive) symptoms in schizophrenia, so you may wish to look into that too.
Posted by JDx on April 15, 2008, at 16:51:17
In reply to Re: cognitive problems from solian, posted by Quintal on April 14, 2008, at 13:27:09
> Sorry, I wasn't suggesting Solian wasn't messing with your memory, just reporting my own experience. I think it does slow me down slightly - my eyes seem to move more slowly and I feel a little drowsy sometimes, but Zyprexa was so much worse.
>
> The benefits you're feeling from Solian are probably due to the dopamine boosting effect, so maybe you could look at substituting it with something else that boosts dopamine, such as Wellbutrin or Ritalin? I'd think they would be less likely to cause cognitive impairment. I don't know about the glycine, but hopefully something like that will work if your condition is mild. Not everyone that has experienced psychosis needs to be on antipsychotics for life, and there are other ways of treating Schizophrenia.
>
> Qfirst of all , thank you for the support and the help.
and i have to say - I really hope you are right about the antipsyhotics, and not being have to take it the rest of my life- though this is critical time for me, because I am a student, and this is the time i need to be at my mental peak
Posted by JDx on April 16, 2008, at 10:12:05
In reply to Re: cognitive problems from solian, posted by undopaminergic on April 15, 2008, at 10:31:59
> Like you, I use methylphenidate (Ritalin, Concerta, etc.) and amisulpride (Solian), but I haven't noticed the memory impairing effect you describe.
>
> One possibility is that amisulpride and methylphenidate potentiate each other too much in some areas of the brain. In particular, the prefrontal cortex is sensitive to excessive dopamine (and noradrenaline) levels. There is evidence that alpha2A-adrenergic agonists are effective for treating such conditions. One such drug - guanfacine - has also proven useful for normalising some cognitive abnormalities in schizotypal personality disorder (a schizophrenia-spectrum disorder). Therefore, guanfacine may be worth a try (it's also good for ADHD).
>
> One study found memantine to be effective for negative (but not cognitive) symptoms in schizophrenia, so you may wish to look into that too.What side effects did you encountered from amisulpride? what are the daignosis your doctor perscribes you ritalin and amisulpride? anxiety and ADHD?
i am wondring what do i have - because if i have schizophrenia, this drug was suppose to inrease my cognitive abilities. and if my brain is normal , it doesn't suppose to do anything in that regard. same if i had adhd.
Before i started taking it i had extremly good photographic memory, i was best in my class in university and considered a genious of some kind..and now, I need to get help from other students in order to understang what is going on in classes,and i am sitting about 10 hours trying to read only a few pages in our work book=[about the medications you suggested,imo memantine could be a possiblity , mainly because it increases libido, and since i am taking ritalin i have no sexual motivation (solian doesn't help it, though risperdal and quetiapine did help)
Posted by undopaminergic on April 16, 2008, at 14:52:23
In reply to Re: cognitive problems from solian » undopaminergic, posted by JDx on April 16, 2008, at 10:12:05
> > Like you, I use methylphenidate (Ritalin, Concerta, etc.) and amisulpride (Solian), but I haven't noticed the memory impairing effect you describe.
> >
> > One possibility is that amisulpride and methylphenidate potentiate each other too much in some areas of the brain. In particular, the prefrontal cortex is sensitive to excessive dopamine (and noradrenaline) levels. There is evidence that alpha2A-adrenergic agonists are effective for treating such conditions. One such drug - guanfacine - has also proven useful for normalising some cognitive abnormalities in schizotypal personality disorder (a schizophrenia-spectrum disorder). Therefore, guanfacine may be worth a try (it's also good for ADHD).
> >
> > One study found memantine to be effective for negative (but not cognitive) symptoms in schizophrenia, so you may wish to look into that too.
>
> What side effects did you encountered from amisulpride? what are the daignosis your doctor perscribes you ritalin and amisulpride? anxiety and ADHD?
>ADHD (inattentive type) and (atypical) depression. I also meet the diagnostic criteria for schizoid personality disorder, but I'm not diagnosed with it. I haven't noticed any side effects at all from amisulpride (50-100 mg), probably because I had been taking the very similar drug sulpiride before it. In the beginning of trying larger doses of sulpiride I noticed some adverse effects on motor coordination, but they went away within a week or so.
>
> i am wondring what do i have - because if i have schizophrenia, this drug was suppose to inrease my cognitive abilities.
>That is probably true if you have psychotic symptoms such as paranoid delusions and thought disorder. However, if you only have negative symptoms such as anhedonia and lack of motivation, then antipsychotics are unlikely to improve cognition much. The stimulating properties of amisulpride at low doses (up to 100 mg or so) can help with motivation. In my experience, Ritalin is also useful for that purpose, and also improves cognition, including memory, attention and verbal skills.
> and if my brain is normal , it doesn't suppose to do anything in that regard. same if i had adhd.
> Before i started taking it i had extremly good photographic memory, i was best in my class in university and considered a genious of some kind..and now, I need to get help from other students in order to understang what is going on in classes,and i am sitting about 10 hours trying to read only a few pages in our work book=[
>That's quite a decline. You really should try making some adjustments in doses and medications to see if you can improve the situation.
Some examples:
* try higher doses of amisulpride - it can get better or worse, but you can learn from the experience
* try lower doses of Ritalin - you may find that you need less of it now that you take amisulpride
* lower the amisulpride dose and take more Ritalin instead - perhaps you can get the same benefits with fewer side effects
* try adding guanfacine - can help with memory and cognitition
* try adding modafinil - see above
* try replacing Ritalin with modafinil - perhaps modafinil has the same benefits but fewer side effects
* add an anxiolytic (benzodiazepine) and lower amisulpride
* add memantine - with and without removing one or more other drugs
* add some lithium, oxcarbazepine or other anticonvulsants or mood stabilisers
* etc...
Posted by JDx on April 19, 2008, at 18:32:44
In reply to Re: cognitive problems from solian, posted by undopaminergic on April 16, 2008, at 14:52:23
> > > Like you, I use methylphenidate (Ritalin, Concerta, etc.) and amisulpride (Solian), but I haven't noticed the memory impairing effect you describe.
> > >
> > > One possibility is that amisulpride and methylphenidate potentiate each other too much in some areas of the brain. In particular, the prefrontal cortex is sensitive to excessive dopamine (and noradrenaline) levels. There is evidence that alpha2A-adrenergic agonists are effective for treating such conditions. One such drug - guanfacine - has also proven useful for normalising some cognitive abnormalities in schizotypal personality disorder (a schizophrenia-spectrum disorder). Therefore, guanfacine may be worth a try (it's also good for ADHD).
> > >
> > > One study found memantine to be effective for negative (but not cognitive) symptoms in schizophrenia, so you may wish to look into that too.
> >
> > What side effects did you encountered from amisulpride? what are the daignosis your doctor perscribes you ritalin and amisulpride? anxiety and ADHD?
> >
>
> ADHD (inattentive type) and (atypical) depression. I also meet the diagnostic criteria for schizoid personality disorder, but I'm not diagnosed with it. I haven't noticed any side effects at all from amisulpride (50-100 mg), probably because I had been taking the very similar drug sulpiride before it. In the beginning of trying larger doses of sulpiride I noticed some adverse effects on motor coordination, but they went away within a week or so.
>
> >
> > i am wondring what do i have - because if i have schizophrenia, this drug was suppose to inrease my cognitive abilities.
> >
>
> That is probably true if you have psychotic symptoms such as paranoid delusions and thought disorder. However, if you only have negative symptoms such as anhedonia and lack of motivation, then antipsychotics are unlikely to improve cognition much. The stimulating properties of amisulpride at low doses (up to 100 mg or so) can help with motivation. In my experience, Ritalin is also useful for that purpose, and also improves cognition, including memory, attention and verbal skills.
>
> > and if my brain is normal , it doesn't suppose to do anything in that regard. same if i had adhd.
> > Before i started taking it i had extremly good photographic memory, i was best in my class in university and considered a genious of some kind..and now, I need to get help from other students in order to understang what is going on in classes,and i am sitting about 10 hours trying to read only a few pages in our work book=[
> >
>
> That's quite a decline. You really should try making some adjustments in doses and medications to see if you can improve the situation.
>
> Some examples:
> * try higher doses of amisulpride - it can get better or worse, but you can learn from the experience
> * try lower doses of Ritalin - you may find that you need less of it now that you take amisulpride
> * lower the amisulpride dose and take more Ritalin instead - perhaps you can get the same benefits with fewer side effects
> * try adding guanfacine - can help with memory and cognitition
> * try adding modafinil - see above
> * try replacing Ritalin with modafinil - perhaps modafinil has the same benefits but fewer side effects
> * add an anxiolytic (benzodiazepine) and lower amisulpride
> * add memantine - with and without removing one or more other drugs
> * add some lithium, oxcarbazepine or other anticonvulsants or mood stabilisers
> * etc...
>
thx, i'll try that after i will try glycine . yesterday i got the order of 1 kilo glycine, and it seem to have intersting effect. increaing cognition,memory, attetion- mybe it will replace ritalin and solian togther..I also asked yesterday my doctor what do he think i have, and he said he is not sure. He thought schizophrenia+ocd+ocpd+schizoid personality ,and he isn't sure i am adhd-ia..
About your daignosis, i think that ritalin itself can 'flatten' your motivions , and mybe thats why you feel like schizoid personality. especilly if you have adhd-ia who usually has low motivions..
i remember that when i took risperidone , it increased all my low motivions - and i felt like before i took ritlain for the first time.
It makes sens, i mean- ritalin messes with dopamine in all synapses in the brain, and not only those realated to attation, but also those which responsible for motivations
>
Posted by undopaminergic on April 21, 2008, at 4:53:36
In reply to Re: cognitive problems from solian » undopaminergic, posted by JDx on April 19, 2008, at 18:32:44
>
> About your daignosis, i think that ritalin itself can 'flatten' your motivions , and mybe thats why you feel like schizoid personality.
>No, the symptoms existed before Ritalin, which is one of the attempts to treat them.
> especilly if you have adhd-ia who usually has low motivions..
> i remember that when i took risperidone , it increased all my low motivions - and i felt like before i took ritlain for the first time.
>That's interesting, as my experience with risperidone was the opposite: it made me lethargic, and more apathetic and anhedonic.
> It makes sens, i mean- ritalin messes with dopamine in all synapses in the brain, and not only those realated to attation, but also those which responsible for motivations
> >Yes, but in my experience it improves motivation - at least until tolerance develops. The drug tends to lose it efficacy, necessitating "drug holidays" to restore effectiveness.
Posted by JDx on April 23, 2008, at 5:40:29
In reply to Re: cognitive problems from solian, posted by undopaminergic on April 21, 2008, at 4:53:36
> No, the symptoms existed before Ritalin, which is one of the attempts to treat them.
>IMO ritalin is a bad choice in order to improve motivations.as far as i know high amount of dopamine activity doesn't reflect good working motivations but other aspects like rate of fire and pattern of fire of DA neurons, and ritalin doesn't help with that ( on the contrary)
> That's interesting, as my experience with risperidone was the opposite: it made me lethargic, and more apathetic and anhedonic.
>
well , I make differentiation between the serotnin antagonism mechanism which makes the depression like symptoms you described, and the DA (and NE) mechanism which has the antipsychotic effect which
fix the motivations aspects- that in my experience reflects in me having additional value to perception of things ie-when i am taking Risperdal I really have sexual desire towards women , i really enjoy watching women, curiosity to learn things, and excitments from little things; though it decreases my mood and makes me feel depressed - which makes me low energy , not happy etc..
> > It makes sens, i mean- ritalin messes with dopamine in all synapses in the brain, and not only those realated to attation, but also those which responsible for motivations
> > >
>
> Yes, but in my experience it improves motivation - at least until tolerance develops. The drug tends to lose it efficacy, necessitating "drug holidays" to restore effectiveness.
>
>
As far as i know tolerance doesn't develops with ritalin (otherwise you would need to increase ritalin dosage every few months). Mybe because it has short half-life , and DA receptors in the brain has time reAdjust at night when no ritalin in your blood..
Posted by undopaminergic on April 24, 2008, at 15:53:44
In reply to Re: cognitive problems from solian » undopaminergic, posted by JDx on April 23, 2008, at 5:40:29
>
> > No, the symptoms existed before Ritalin, which is one of the attempts to treat them.
> >
>
> IMO ritalin is a bad choice in order to improve motivations.as far as i know high amount of dopamine activity doesn't reflect good working motivations but other aspects like rate of fire and pattern of fire of DA neurons, and ritalin doesn't help with that ( on the contrary)
>You may wish to review the research on this matter, as it strongly indicates an essential role of dopamine in motivation. Try these, for example:
http://www.nature.com/npp/journal/v31/n7/abs/1300966a.html
http://www.ncbi.nlm.nih.gov/pubmed/7718155> > That's interesting, as my experience with risperidone was the opposite: it made me lethargic, and more apathetic and anhedonic.
> >
> well , I make differentiation between the serotnin antagonism mechanism which makes the depression like symptoms you described, and the DA (and NE) mechanism which has the antipsychotic effect which fix the motivations aspects-
>It's true that the DA antagonism is an important antipsychtoic mechanism, but I'm almost certain that it also accounts for what you call "depression like symptoms" (they may be even more like negative symptoms of schizophrenia) and it also produces parkinsonian (extrapyramidal) symptoms at higher doses. By contrast, psychostimulants such as methylphenidate (Ritalin) and amphetamine, as well as low doses of sulpiride and amisulpride that enhance dopamergic neurotransmission, increase motivation, or goal-directed activity.
The blockade of 5-HT2 serotonin receptors by risperidone and most other atypical antipsychotics is considered desirable, and has antidepressant-like effects in some animal models (forced swim test) of depression and negative schizophrenic symptoms. Some antidepressants block the 5-HT2 receptor too (e.g. mirtazapine), and atypical antipsychotics are sometimes combined with antidepressants in an effort to improve efficacy.
> that in my experience reflects in me having additional value to perception of things ie-when i am taking Risperdal I really have sexual desire towards women , i really enjoy watching women, curiosity to learn things, and excitments from little things;
>Some people do experience increased interest in certain things as a result of risperidone. I can't say that I noticed anything of the kind.
> though it decreases my mood and makes me feel depressed - which makes me low energy , not happy etc..
>That is unsurprising.
> > Yes, but in my experience it improves motivation - at least until tolerance develops. The drug tends to lose it efficacy, necessitating "drug holidays" to restore effectiveness.
> >
> >
> As far as i know tolerance doesn't develops with ritalin (otherwise you would need to increase ritalin dosage every few months).
>Yes, indeed, I have to increase the dose at weekly intervals or less, until I reach 40 mg per dose (or 108 mg of Concerta, a prolonged release formulation of methylphenidate), which can be sustained for approximately a month, after which almost all effect is lost. Apparently, the dose-reponse curve flattens at that point, as further dose increases have little effect.
> Mybe because it has short half-life , and DA receptors in the brain has time reAdjust at night when no ritalin in your blood..
>That may be true if you take only one dose of immediate release methylphenidate, but that's not enough to maintain effectiveness for a whole day.
Posted by Sigismund on April 27, 2008, at 2:06:42
In reply to Re: cognitive problems from solian, posted by undopaminergic on April 24, 2008, at 15:53:44
I found Ritalin best for activities where there was no question of doing them for enjoyment.
It was good for exams, and 30 years later I can still remember admiring the library carpet.
Not much good for reading though.
This is the end of the thread.
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