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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by elanor roosevelt on April 12, 2008, at 1:44:41
Lamictal is slow to settle into
a bit of sn edge
tr provigil mskes me an aggresive jerkthinking abot retutnring to tio adderall and lamictal
Posted by dbc on April 12, 2008, at 3:36:59
In reply to ADVICE Lamictal and addaerall or provigal???, posted by elanor roosevelt on April 12, 2008, at 1:44:41
Either way its a bunch of NE causing you to be edgy but at least the adderal can be productive.
Posted by undopaminergic on April 12, 2008, at 20:20:00
In reply to Re: ADVICE Lamictal and addaerall or provigal???, posted by dbc on April 12, 2008, at 3:36:59
Modafinil (Provigil) is generally less adrenergic than amphetamines (Adderall), so it seems somewhat unlikely that this would be a NE (noradrenaline) effect.
Have you tried methylphenidate? What was your experience with that?
Also, if you've tried cocaine, how did you react?
Posted by CareBear04 on April 13, 2008, at 21:31:14
In reply to Re: ADVICE Lamictal and addaerall or provigal???, posted by undopaminergic on April 12, 2008, at 20:20:00
hi, i'm just curious-- why do you ask about cocaine? is cocaine similar in structure/mode of action/reaction to adderall or provigil?
thanks!
cb
Posted by dbc on April 14, 2008, at 14:59:18
In reply to Re: ADVICE Lamictal and addaerall or provigal??? » undopaminergic, posted by CareBear04 on April 13, 2008, at 21:31:14
> hi, i'm just curious-- why do you ask about cocaine? is cocaine similar in structure/mode of action/reaction to adderall or provigil?
> thanks!
> cbPsychiatrists refer to ritalin/methylphenidate as "kiddie cocaine" because it shares similar neurological effects. Thus if you responded favoribly to cocaine you may respond better to ritalin than amphetamine (adderal).
Posted by undopaminergic on April 15, 2008, at 0:57:34
In reply to Re: ADVICE Lamictal and addaerall or provigal???, posted by dbc on April 14, 2008, at 14:59:18
> > hi, i'm just curious-- why do you ask about cocaine? is cocaine similar in structure/mode of action/reaction to adderall or provigil?
> > thanks!
> > cb
>
> Psychiatrists refer to ritalin/methylphenidate as "kiddie cocaine" because it shares similar neurological effects. Thus if you responded favoribly to cocaine you may respond better to ritalin than amphetamine (adderal).
>Methylphenidate, cocaine and modafinil are all dopamine reuptake inhibitors. It's likely that oral cocaine, as a sustained release formulation, would be quite effective for treating ADHD without inducing a "high". Meanwhile, it has been demonstrated (in experienced cocaine users) that intravenous methylphenidate is indistinguishable from cocaine (modafinil isn't soluble, so it can't be injected).
There are still notable differences between the drugs, of course.
Amphetamine (Adderall), however, differs quite substantially. It releases dopamine (DA), whereas the others only block the reuptake of DA that was already released. Therefore, amphetamine can effect much higher increases in extracellular DA than any of the others, and can be useful where the others lack efficacy. Another effect that distinguishes amphetamine from the others is that its long-term abuse is associated with pathological changes in several radiological markers of dopaminergic function - this can be visualised with brain imaging techniques.
Posted by elanor roosevelt on April 16, 2008, at 22:26:28
In reply to Re: ADVICE Lamictal and addaerall or provigal???, posted by undopaminergic on April 15, 2008, at 0:57:34
well i reacted to cocaine just fine
but reacting well to a recreational drug is easier than making a life with a drug
Posted by undopaminergic on April 18, 2008, at 5:09:03
In reply to Re: ADVICE Lamictal and addaerall or provigal???, posted by elanor roosevelt on April 16, 2008, at 22:26:28
> well i reacted to cocaine just fine
>
> but reacting well to a recreational drug is easier than making a life with a drug
>That depends on how reliably the drug works - eg. whether tolerance develops, and how expensive the drug is - that is, whether you can afford enough of it for regular and sustained usage. And of course, if you're taking the drug intranasally, there is also the question of whether the mucosa will endure the treatment (there have been cases of perforated nasal septa resulting from excessive insufflation of cocaine).
Posted by elanor roosevelt on April 19, 2008, at 1:53:43
In reply to Re: ADVICE Lamictal and addaerall or provigal???, posted by undopaminergic on April 18, 2008, at 5:09:03
> That depends on how reliably the drug works - eg. whether tolerance develops, and how expensive the drug is - that is, whether you can afford enough of it for regular and sustained usage. And of course, if you're taking the drug intranasally, there is also the question of whether the mucosa will endure the treatment (there have been cases of perforated nasal septa resulting from excessive insufflation of cocaine).
there is also the heart attack thing that took some of my cocaine friends pretty young
This is the end of the thread.
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