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Dr. Bob is Robert Hsiung, MD,
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Posted by Larry Hoover on April 7, 2008, at 17:12:34
This report, just published in the Canadian Medical Association Journal, reveals that completed child and adolescent suicide rates nearly quadrupled in a comparison of the two years following antidepressant warnings, when compared to the nine years prior to those warnings. The full-text states the increase was 25%, but the rate increased from 4/100,000 to 15/100,000. I see no explanation for the discrepancy.
Full text here: http://www.cmaj.ca/cgi/content/full/178/8/1005
Abstract:
Effect of regulatory warnings on antidepressant prescription rates, use of health services and outcomes among children, adolescents and young adults.
Laurence Y. Katz, MD, Anita L. Kozyrskyj, PhD, Heather J. Prior, MSc, Murray W. Enns, MD, Brian J. Cox, PhD and Jitender Sareen, MD
From the Department of Psychiatry (Katz, Enns, Cox, Sareen), University of Manitoba; and the Manitoba Centre for Health Policy, Department of Community Health Sciences (Kozyrskyj, Prior), University of Manitoba, Winnipeg, Man.Correspondence to: Dr. Laurence Katz, Department of Psychiatry, University of Manitoba, Rm. PZ-162, 771 Bannatyne Ave., Winnipeg MB R3E 3N4; fax 204 787-4975; lkatz@hsc.mb.ca
Background: Regulatory bodies worldwide, including Health Canada, have issued warnings about prescribing antidepressants to children and adolescents. We sought to determine whether the Health Canada warning had the desired effects on prescribing patterns and outcomes and whether it had any unintended health consequences.
Methods: We examined data from prescription and health care databases representing more than 265 000 children, adolescents and young adults annually to determine changes in the rates of antidepressant prescription, use of health services and outcomes in these populations in the 9 years before and the 2 years after the Health Canada warning. We also examined the data for unintended changes in these rates among patients with anxiety disorders. We used young adults as the comparison group because they were not targeted by the warning.
Results: Following the warning, the rate of antidepressant prescriptions decreased among children and adolescents (relative risk [RR] 0.86, 95% confidence interval [CI] 0.810.91) and among young adults (RR 0.90, 95% CI 0.860.93). Ambulatory visits because of depression decreased among children and adolescents (RR 0.90, 95% CI 0.850.96) and young adults (RR 0.91, 95% CI 0.870.96). The rate of completed suicides among children and adolescents rose significantly after the warning (RR 1.25, 95% CI 1.081.44; annual rate per 1000 = 0.04 before and 0.15 after the warning). There was no equivalent change in the rate of completed suicides among young adults (RR 1.01, 95% CI 0.931.10; annual rate per 1000 = 0.15 before and 0.22 after the warning). Among patients with an anxiety disorder, the prescription rates did not change among children and adolescents, except for a decrease in the use of selective serotonin reuptake inhibitors other than fluoxetine, but the rates among young adults changed similar to the pattern of changes in the overall prescribing of antidepressants. There was also a significant decrease in the rate of physician visits because of anxiety disorders among young adults after the warning.
Interpretation: Health advisories and warnings issued by regulatory bodies may have unintended consequences on the provision of care, delivery of health services and clinical outcomes. Further efforts are required to ensure that health warnings do not result in unexpected harm.
Posted by Phillipa on April 7, 2008, at 18:38:24
In reply to Child and adolescent suicide rate skyrockets, posted by Larry Hoover on April 7, 2008, at 17:12:34
Why did doctors visits decrease and how are the kids and teens being treated if not responsive to prozac? I never thought kids should be medicated as my grandson was once and knocked over boxes in a store as he couldn't walk straight . Taken off ad's then never to take one again he didn't need it. Phillipa
Posted by llurpsienoodle on April 8, 2008, at 10:17:49
In reply to Re: Child and adolescent suicide rate skyrockets » Larry Hoover, posted by Phillipa on April 7, 2008, at 18:38:24
Paradoxical how a warning can lead to adverse consequences. I wonder how cigarette warnings work...
Interesting study, thanks for bringing it up.
-Ll
Posted by Maxime on April 8, 2008, at 19:46:42
In reply to Re: Child and adolescent suicide rate skyrockets » Larry Hoover, posted by Phillipa on April 7, 2008, at 18:38:24
> Why did doctors visits decrease and how are the kids and teens being treated if not responsive to prozac? I never thought kids should be medicated as my grandson was once and knocked over boxes in a store as he couldn't walk straight . Taken off ad's then never to take one again he didn't need it. Phillipa
There is more than Prozac out there.
It's too bad that meds are seen as the only answer. The suicide rate may not have increased if the kids had been brought to a therapist.
We will never know.
And Phillipa, you know that not all kids are the same.
Maxime
This is the end of the thread.
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