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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by RicCory on March 24, 2008, at 17:51:45
Does anyone have any experience with taking Stablon and Cymbalta at the same time? I know that one is a serotonin reuptake inhibitor and the other a reuptake enhancer--and intuitively, one might think they cancel each other out--but, I don't think it's that simple.
I have been on Stablon (4x12.5 mg/day) and Wellbutrin (2x150 mg/day) for a about 6 weeks. I originally was only taking 3 Stablon & 1 Wellbutrin, but that didn't feel effective. My guess is that the bulk of the effectiveness now is coming from Wellbutrin.
I have taken SSRIs before and quit mainly because of their typical side effects. I've taken Cymbalta before as well as know, for me, its action is swift and effective, but also causes the typical SSRI side effects.
I wonder if the addition of Stablon might negate some of the "soaking-in-serotonin" side effects of Cymbalta, while not compromising efficacy?
Any thoughts on or experiences with Cymbalta (or SSRI) and Stablon would be much appreciated.
RC
Posted by Phillipa on March 24, 2008, at 19:50:10
In reply to Stablon with Cymbalta? Experience, thoughts?, posted by RicCory on March 24, 2008, at 17:51:45
Just cymbalta three months at 60mg got rid of backpain but that's it for me. Hear great things about it though. Phillipa
Posted by bleauberry on March 24, 2008, at 20:08:29
In reply to Stablon with Cymbalta? Experience, thoughts?, posted by RicCory on March 24, 2008, at 17:51:45
I saw a case study at pubmed where a woman failed regular antidepressants and failed stablon but responded remarkably to a combination of an antidepressant and stablon combination. Unfortunately they did not cite what the other antidepressant was.
I believe these drugs are way way way too complicated to look at it as simply serotonin reuptake inhibition or serotonin reuptake enhancement. There is a whole lot more going on that researchers have only scratched the surface. So yeah, based on limited logic of what these drugs do it would not make sense to combine them. But I think the combination is certianly worth a try, based on at least one other person's success and based on your own experience in combining it.
Posted by bulldog2 on March 24, 2008, at 20:12:01
In reply to Re: Stablon with Cymbalta? Experience, thoughts? » RicCory, posted by Phillipa on March 24, 2008, at 19:50:10
> Just cymbalta three months at 60mg got rid of backpain but that's it for me. Hear great things about it though. Phillipa
How's the current nardil trial going? Do you still enjoy my sweet kisses on your soles?
Posted by Phillipa on March 25, 2008, at 17:53:46
In reply to Re: Stablon with Cymbalta? Experience, thoughts?, posted by bulldog2 on March 24, 2008, at 19:12:01
Kisses are great nardil no trial. Love Phillipa
Posted by RicCory on April 2, 2008, at 17:45:35
In reply to Re: Stablon with Cymbalta? Experience, thoughts?, posted by bleauberry on March 24, 2008, at 20:08:29
Okay, so here's my plan of attack:
CURRENTLY ON:
--Stablon (12.5 mg x 3)
--Wellbutrin SR (150 mg x 2)MOVING TOWARDS:
--CYMBALTA (40 mg then 60mg to maximize effect of NE and thus motivation)
--WELLBUTRIN SR (150 mg x 1 in the morning to avoid sleeplessness issues of the second late afternoon dose)
--STABLON (12.5 mg x 1 *** I want to see if this single dose a few hours before sexual activity will mitigate the negative sexual side effects related to soaking in serotonin [reuptake inhibition] through its short-term facilitation of reuptake enhancement)In my analytical mind--this sounds like the ideal solution! Imagine if one actually existed!!!
I'll try to keep updating if others are interested.
RC
Posted by Peter on December 13, 2014, at 0:57:28
In reply to Re: Stablon with Cymbalta? Experience, thoughts?, posted by RicCory on April 2, 2008, at 17:45:35
>> hey Ric! I know I'm re-opening a 6-year old thread - and that you may not even see this - but I would love to know how you did on the Cymbalta/Stablon combo. I've been taking CYMBALTA for about 10 years, but most of that time at only sub-therapeutic doses, like 20mg - because I was on such an enormous mix of meds and my pDoc was always making adjustments, trying to taper me off some while raising others, etc... About 2 months ago I had a complete breakdown and all my symptoms - social anxiety, agoraphobia, severe depression - got too intense. My pDoc first tried adding Remeron, as I'd never tried it before, but I had a bad reaction to it (intense derealization and worse anxiety, surprisingly). He then decided that the best thing to try would be to work with what I was already taking instead of introduce a brand new drug to my hypersensitive brain. So he had me increase my CYMBALTA from 20mg to 30mg for 2 weeks, then to 40mg about a week ago. I only began to feel the veil lift ever so slightly yesterday, & am sure he will have me keep increasing its dose. However, I already feel the familiar emotional numbness, and markedly decreased libido.
I've been fascinated with Tianeptine ever since first reading about it; but I assumed that it was not an option for me since its a serotonin reuptake enhancer and I've been on a bunch of meds that work to increase serotonin. So I assumed tianeptine would push me into some horrible SSRI/SNRI discontinuation syndrome. But if there's a possibility that I can safely take it along with my CYMBALTA to further help my mood and to mitigate the SNRI side effects, I would love to talk to my pDoc about trying it out. So, can you let me know how your trial was combining the two? I hope you see this; and sorry for my wordiness - I tend to go on and on :(
Thanks,
Peter> Okay, so here's my plan of attack:
> CURRENTLY ON:
> --Stablon (12.5 mg x 3)
> --Wellbutrin SR (150 mg x 2)
>
> MOVING TOWARDS:
> --CYMBALTA (40 mg then 60mg to maximize effect of NE and thus motivation)
> --WELLBUTRIN SR (150 mg x 1 in the morning to avoid sleeplessness issues of the second late afternoon dose)
> --STABLON (12.5 mg x 1 *** I want to see if this single dose a few hours before sexual activity will mitigate the negative sexual side effects related to soaking in serotonin [reuptake inhibition] through its short-term facilitation of reuptake enhancement)
>
> In my analytical mind--this sounds like the ideal solution! Imagine if one actually existed!!!
>
> I'll try to keep updating if others are interested.
>
> RC
>
This is the end of the thread.
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