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Dr. Bob is Robert Hsiung, MD,
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Posted by Jimmyboy on December 26, 2007, at 9:36:04
Anyone know?
Thanks
JB
Posted by zeugma on December 26, 2007, at 12:35:00
In reply to Are there any non-sedating 5ht2 antagonists??????, posted by Jimmyboy on December 26, 2007, at 9:36:04
Purportedly, 5HT2A antagonism is sedating, while 5HT2C antagonism is alerting.
There are no pure 5HT2 antagonists on the market, for the same reason gepirone didn't make it (they are likely best as augmentation).
Posted by linkadge on December 28, 2007, at 22:50:01
In reply to Re: Are there any non-sedating 5ht2 antagonists?????? » Jimmyboy, posted by zeugma on December 26, 2007, at 12:35:00
Many 5-ht2 antagonists are also antihistamines which complicates the matter.
The herb feverfew is a fairly potent 5-ht2a/b antagonist with little sedation (that I noticed). It seemed anxiolytic but not sedating.
Linkadge
Posted by zeugma on December 30, 2007, at 18:00:41
In reply to Re: Are there any non-sedating 5ht2 antagonists??????, posted by linkadge on December 28, 2007, at 22:50:01
This link has an interesting chart where you can see the pathways/neurotransmitters/receptors involved in sleep/wakefulness:
http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1365-2125.2006.02680.x
This is the end of the thread.
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