Psycho-Babble Medication Thread 800769

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what is a D2(High) receptor?

Posted by iforgotmypassword on December 14, 2007, at 12:22:18

just looking at this:

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=18000814&ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

also wondering if they mean indirect agonism, by increasing dopamine or dopamine sensitivity, or direct, by memantine having actual affinity at the receptor.

Re: what is a D2(High) receptor?

Posted by Netch on December 15, 2007, at 1:06:30

In reply to what is a D2(High) receptor?, posted by iforgotmypassword on December 14, 2007, at 12:22:18

Memantine has direct affinity at the receptor

/Netch

Re: what is a D2(High) receptor?

Posted by Netch on December 15, 2007, at 1:19:05

In reply to what is a D2(High) receptor?, posted by iforgotmypassword on December 14, 2007, at 12:22:18

The D2 receptor can be pre- or postsynaptic.
The presynaptic receptor has modulatory functions. The postsynaptic receptor has excitatory or inhibitory effect.
Many neuroleptics have modulatory/inhibitory effect on the D2 receptor.

http://en.wikipedia.org/wiki/Dopamine_receptor

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