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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 4 to 28 of 39. Go back in thread:
Posted by Phillipa on October 27, 2007, at 20:02:17
In reply to Re: Who is doing well on Deplin?, posted by King of Nothing on October 27, 2007, at 17:44:42
King seems a person with a lot of knowledge who used to post here is having great success with it and a friend of his too. Phillipa
Posted by Ron Hill on October 27, 2007, at 23:29:26
In reply to Who is doing well on Deplin?, posted by King of Nothing on October 27, 2007, at 13:22:43
I've been taking Deplin (L-methylfolate) for the past six days and, so far I am enjoying a remarkable benefit in the tx of my bipolar depressive phase. It has completely eliminated my depression.
I am currently taking 15 mg/day of Deplin.
Will it last? Time will tell. But in the meantime, I'm enjoying life without depression.
http://www.deplin.com/
Click through all the links.-- Ron
Bipolar II with ultra rapid cycling (15 day cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)
600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day Nardil
15 mg/day Deplin
Posted by King of Nothing on October 28, 2007, at 9:32:04
In reply to Re: Who is doing well on Deplin? » King of Nothing, posted by Ron Hill on October 27, 2007, at 23:29:26
Great for you Ron!! I hope to join you soon.
Posted by stargazer2 on October 28, 2007, at 21:05:15
In reply to Who is doing well on Deplin?, posted by King of Nothing on October 27, 2007, at 13:22:43
Can you buy methylfolate still on-line. I have seen other methylfolate pills but they have other things in them, like B-12 and B-6. Also the dose of Methylfolate is not 7.5 mg, but 800 mcg.
Would this work as well as Deplin? How many pills would you have to take to equal the dose of Deplin? Would taking a product with B-12 and B-6 do any harm or could it be helpful?
I'll ask my doc for a script of Deplin if I can't find it on line but I wanted to get it without a prescription if possible. I spend too much on co-pays as it is and since it is a vitamin, my insurance may not even cover it yet. That's probably what will happen anyway...
Stargazer
Posted by Phillipa on October 28, 2007, at 22:26:05
In reply to Where can you buy L-methylfolate?, posted by stargazer2 on October 28, 2007, at 21:05:15
No it's a prescription even Dr. Bob redirected the thread back to meds from alternative. Evidently it works well with nardil . Phillipa
Posted by stargazer2 on October 28, 2007, at 23:20:12
In reply to Re: Where can you buy L-methylfolate? » stargazer2, posted by Phillipa on October 28, 2007, at 22:26:05
Deplin is the prescription but there is still (?) a limited supply of L-methylfolate available without a prescription. I wanted to try that first before getting a prescription from my pdoc. I'm sure my insurance will not cover it, it's too new.
Stargazer
Posted by King of Nothing on October 29, 2007, at 10:39:57
In reply to Re: Where can you buy L-methylfolate?, posted by stargazer2 on October 28, 2007, at 23:20:12
> Deplin is the prescription but there is still (?) a limited supply of L-methylfolate available without a prescription. I wanted to try that first before getting a prescription from my pdoc. I'm sure my insurance will not cover it, it's too new.
>
> StargazerI just read that ONE Deplin is bioequivalent to taking SEVENTY-FIVE 800 mcg. folic acid pills!
Posted by stargazer2 on October 29, 2007, at 13:44:56
In reply to Re: Where can you buy L-methylfolate?, posted by King of Nothing on October 29, 2007, at 10:39:57
Oh great and I hate to take pills. Someone else said they were taking 3.2 mg of L-methylfolate,I wonder how they get that amount if they are taking a pill that contains 800 mcg of Folate.
SG
Posted by Marty on October 29, 2007, at 13:58:03
In reply to Re: Where can you buy L-methylfolate?, posted by King of Nothing on October 29, 2007, at 10:39:57
It's not because it doesn't work for some that it will not work for you buddy. Some people here are so resistant that they wouldn't feel better if they were to receive a 'Ron Jeremys Brain Transplantation' .. got my drift ? ;)What you're looking for probably work for LESS people than MORE. I'd say that if you have enough money to try it.. then do.
Don't be to Phillipian about it :D
If you try it, keep me posted plz.
I hope you'll feel better soon buddy.
Marty
Posted by King of Nothing on October 29, 2007, at 15:04:17
In reply to Marty -) King of Nothing, posted by Marty on October 29, 2007, at 13:58:03
>
> It's not because it doesn't work for some that it will not work for you buddy. Some people here are so resistant that they wouldn't feel better if they were to receive a 'Ron Jeremys Brain Transplantation' .. got my drift ? ;)
>
> What you're looking for probably work for LESS people than MORE. I'd say that if you have enough money to try it.. then do.
>
> Don't be to Phillipian about it :D
>
> If you try it, keep me posted plz.
>
> I hope you'll feel better soon buddy.
> MartyMe too:) And be careful w/that Primose Oil...if your breasts enlarge and you start to get Bitchy stop immedietely! LOL
-King Long Dong
Posted by Marty on October 29, 2007, at 17:47:51
In reply to Re: Marty -) King of Nothing, posted by King of Nothing on October 29, 2007, at 15:04:17
> Me too:) And be careful w/that Primose Oil...if your breasts enlarge and you start to get Bitchy stop immedietely! LOL
>
> -King Long Dong
LOL :P
Posted by Phillipa on October 29, 2007, at 19:50:30
In reply to Marty -) King of Nothing, posted by Marty on October 29, 2007, at 13:58:03
Marty that was funny. Phillipa
Posted by Phillipa on October 29, 2007, at 19:52:59
In reply to Re: Marty -) King of Nothing, posted by King of Nothing on October 29, 2007, at 15:04:17
Here we go again . Love Phillipa
Posted by KayeBaby on October 30, 2007, at 20:37:07
In reply to Re: Marty -) King of Nothing » King of Nothing, posted by Phillipa on October 29, 2007, at 19:52:59
l-methylfolate and Deplin are the same thing.
800mcg x 4= 3.2mg ??Is my math wrong? I suck at calculations.
Kaye
Posted by stargazer2 on October 31, 2007, at 8:35:19
In reply to Re: Marty -) King of Nothing, posted by KayeBaby on October 30, 2007, at 20:37:07
Kaye, you have to convert from microgram to milligrams first, so your calculation is not correct. I can't remember how to do this myself but someone here should be able to help.
SG
Posted by Larry Hoover on October 31, 2007, at 8:49:02
In reply to Conversion of mcg(micrograms) to mg(milligrams), posted by stargazer2 on October 31, 2007, at 8:35:19
> Kaye, you have to convert from microgram to milligrams first, so your calculation is not correct. I can't remember how to do this myself but someone here should be able to help.
> SGmicro- prefix meaning one millionth, contracted to mc (or the Greek lower case mu)
mili- prefix meaning one thousandth, contracted to mmicro to mili: divide by 1000
mili to micro: multiply by 1000By the way, if anyone ever has a problem with unit conversions, the Google search window is also a unit conversion engine. Type in something like e.g. "3 miles in centimeters", and it will tell you how many there are. Natural language structure is fine.
Lar
Posted by stargazer2 on November 1, 2007, at 8:36:33
In reply to Re: Conversion of mcg(micrograms) to mg(milligrams) » stargazer2, posted by Larry Hoover on October 31, 2007, at 8:49:02
Larry, so the question is how many 800 mcg pills equal 7.5 mg deplin..
If 7.5 mg = 7500 mcg, then you divide 7500 mcg by 800 mcg and get approx. 10.
Does anyone know if this is correct? I thought i read something like 70 pills of 800 mcg were necessary to equal 7.5 mg deplin.
I get 10. Can anyone verify this number?
SG
Posted by Larry Hoover on November 1, 2007, at 11:43:41
In reply to Re: Conversion of mcg(micrograms) to mg(milligrams), posted by stargazer2 on November 1, 2007, at 8:36:33
> Larry, so the question is how many 800 mcg pills equal 7.5 mg deplin..
>
> If 7.5 mg = 7500 mcg, then you divide 7500 mcg by 800 mcg and get approx. 10.
>
> Does anyone know if this is correct? I thought i read something like 70 pills of 800 mcg were necessary to equal 7.5 mg deplin.
>
> I get 10. Can anyone verify this number?
>
> SGYou're doing that conversion properly, but I think the original comparison was of two different substances, also. Folate is not directly comparable to l-methylfolate, so that also enters into the comparison. By inference, folate supplementation gives approximately one seventh the yield of l-methylfolate? Thus, you would need (10 times) times (7 times) the amount of folate to yield the bioequivalent dose of 7.5 mg of preformed l-methylfolate.
Lar
Posted by Ron Hill on November 1, 2007, at 14:56:14
In reply to Re: Conversion of mcg(micrograms) to mg(milligrams), posted by stargazer2 on November 1, 2007, at 8:36:33
i read something like 70 pills of 800 mcg were necessary to equal 7.5 mg deplin.
> I get 10. Can anyone verify this number?
------------------
Star,See the bottom half of this web page:
http://www.deplin.com/DeplinFacts,VsFolicAcid-- Ron
Posted by KayeBaby on November 1, 2007, at 21:21:16
In reply to Re: Conversion of mcg(micrograms) to mg(milligrams) » stargazer2, posted by Ron Hill on November 1, 2007, at 14:56:14
L-methylfolate (brand name Metafolin-what I am taking) is the same substance as Deplin. Folate is different-the less bioavailable form.
Kaye
Posted by stargazer2 on November 1, 2007, at 22:26:26
In reply to Re: Conversion of mcg(micrograms) to mg(milligrams), posted by KayeBaby on November 1, 2007, at 21:21:16
Kaye, I thought I read that metafolin was 800 mcg too, not the same as 7.5 mg of Deplin. How many pills of the Metafolin are you taking?
Stargazer
Posted by Phillipa on November 1, 2007, at 22:45:11
In reply to Metafolin dose different than Deplin/Kaye, posted by stargazer2 on November 1, 2007, at 22:26:26
This is getting confusing but the Deplin link says the facts. Haven't google the other but will. Phillipa
Posted by Phillipa on November 1, 2007, at 22:47:46
In reply to Re: Metafolin dose different than Deplin/Kaye, posted by Phillipa on November 1, 2007, at 22:45:11
Metafolin isn't a prescription it is a dietary supplement googled it. Man like I say it's getting confusing. Phillipa
Posted by Phillipa on November 1, 2007, at 22:55:31
In reply to Re: Conversion of mcg(micrograms) to mg(milligrams), posted by KayeBaby on November 1, 2007, at 21:21:16
Found this. Now someone figure it out please. Phillipa ps last part or senence I didn't get.Couldn't copy it.
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Merck's Metafolin receives EU approvalBy Jess Halliday
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09/03/2006 - The EU has given the green light for the use of Merck Eprova's Metafolin, a patented form of folate with superior bioavailability, in dietary supplements and dietetic foods in the EU, thereby giving formulators the means to differentiate their products from those containing folic acid.The EU Standing Committee on the Food Chain and Animal Health voted to include Calcium L-Methylfolate (Metafolin) in the positive list of vitamins covered in the EU Directives 2002/46/EC (food supplements) and 2001/15/EC (foods for particular nutritional uses).
Metafolin is the predominant folate found in foods such as orange juice, green leafy vegetables, salads and yeast, and is a form that can be directly used by the body.Until now, however, supplement-makers have only been able to use synthetically produced folic acid, the most oxidised form of folate which has to be reduced in four metabolic steps for the body to use it.
In fact, although it is the best-known folate form, folic acid does not occur naturally in foods but is produced synthetically.
Merck Eprova has developed a proprietary process for the production of a stable synthetic crystalline L-methylfolate; in the past, stability issues have prevented its use in foods and supplements.
"Metafolin is a proprietary folate with excellent bioavailability. We believe Metafolin is an interesting tool for a differentiation strategy in a highly competitive market," explained product manager Roger Weibel.
A 2003 study involving 24 healthy female volunteers concluded that Metafoline is more than 50 percent more bioavailble than folic acid over an eight hour period - 99.83 AUC (h x nmol/l) compared to 63.94 (Prinz-Langenohl R. et al. J. Inherit. Metab. Dis. 26 (1), 124 2003).
Weibel told NutraIngredients.com that if the metabolic pathway works as it should, folic acid is normally converted to L-methylfolate. But one cannot be one hundred percent sure that all the folic acid will be converted, which may mean that some unmetabolised folic acid remains in the body.
The long-term effects of any such unmetabolised folate acid are unknown - a factor that has led to some criticism of folic acid fortification programmes in countries including the US.
Metafolin is already used in supplements and medical foods in the US, since it was approved by the FDA in 2001. It is not yet approved for use in mainstream foods on either side of the Atlantic, and although this may be a possibility for the future, Weibel said that the company is taking one step at a time.
Since there is awareness about folic acid amongst consumers, Weibel expects that it will be some time before Metafolin becomes equally well-known. However scientific journals and newspapers are increasingly preferring to use the blanket term 'folate'.
Weibel was not able to comment on the company's marketing plan for the EU, save that, since Metafolin is not a commodity but a proprietary substance, this creates the opportunity for product differentiation by leading supplement-makers.
The ingredient has already received several rubber-stamps on the road to EU approval: in October 2004 it was positive evaluation by the European Food Safety Authority (EFSA), and a further positive evaluate from JECFA (Joint FAO/WHO Expert Committee on Food Additives) followed in July 2005.
Merch Eprova general manager Martin Ulmann, General Manager of Merck said that the favourable outcome of the vote enables the company to "provide EU consumers with a naturally occurring folate, at a time when there is growing awareness of the health benefits of folate supplementation."
"Food is the major source for folates. However, in a large part of the population folate intake with food is insufficient. An adequate intake of folates is essential for the
Posted by KayeBaby on November 2, 2007, at 15:42:44
In reply to Re: Conversion of mcg(micrograms) to mg(milligrams), posted by Phillipa on November 1, 2007, at 22:55:31
I am not taking enough to equal 7.5 mg. I am only taking 2 800mcg pills right now.
But...regular folate is much less bioavailable. That is where they get the 75 pills statement.
I am taking L-methylfolate. Deplin is a trade name for L-methylfolate. Metafolin (was) a trade name for L-methylfolate. I am not taking the same amount but am taking the same substance.
Kaye
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Dr. Bob is Robert Hsiung, MD,
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