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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Ftlmatt30 on October 25, 2007, at 0:07:36
i am currently taking 60mg. of cymbalta a day..it is the only antidepressant i have taken over the past 8 years that has helped with my depression
anyways, the question i had was how potent is cymbalta at blocking the reuptake of norepinephrine compared to the older Tricyclic antidepressants and also Staterra?
does it affect norepinephrine more or less than those other ones?
Posted by Mishal on October 25, 2007, at 5:21:25
In reply to Cymbalta,,how potent on norepinephrine reuptake, posted by Ftlmatt30 on October 25, 2007, at 0:07:36
Though I could never go beyond a few weeks with Cymbalta, glad to have one with good benefits with it.Cymbalta inhibits both serotonin and norepinephrine at the same rate. ie. it does this job even at low doses just like imipramine like tricyclics.
Posted by Phillipa on October 25, 2007, at 12:15:49
In reply to Re: Cymbalta,,how potent on norepinephrine reuptake » Ftlmatt30, posted by Mishal on October 25, 2007, at 5:21:25
Mishal do you mean same rate as TCA's??? I also first time tolerated cymbalta. Second time couldn't wonder why guess chemistry was different. Phillipa
Posted by medweirdo on October 25, 2007, at 16:23:20
In reply to Cymbalta,,how potent on norepinephrine reuptake, posted by Ftlmatt30 on October 25, 2007, at 0:07:36
Maybe you find it be helpfull:
http://www.cnsforum.com/imagebank/item/antidep_uptake_specific/default.aspxVenlafaxine most probably is equally to Cymbalta.
Posted by medweirdo on October 25, 2007, at 16:31:58
In reply to Re: Cymbalta,,how potent on norepinephrine reuptak, posted by medweirdo on October 25, 2007, at 16:23:20
forgot to tell you. in the chart the less is the IC50 the more potency is - it might be very misleading.
Posted by Phillipa on October 25, 2007, at 20:03:27
In reply to Re: Cymbalta,,how potent on norepinephrine reuptake » Mishal, posted by Phillipa on October 25, 2007, at 12:15:49
Well I'll be darned other than the pain marketed with cymbalta seems both effexor and cymbalta are comparible from my google search. Phillipa
Posted by yxibow on October 26, 2007, at 13:33:37
In reply to Re: Cymbalta,,how potent on norepinephrine reuptake, posted by Phillipa on October 25, 2007, at 20:03:27
Supposedly 6:1 5HT to NE but that's just an in vitro statistic I think. Its a medication that takes a subtle long path to work but is in my opinion a much less harsh agent than Effexor. Still everyone differs.
This is the end of the thread.
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