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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by Jimmyboy on September 15, 2007, at 18:45:41
as many people know around the world, alcohol, ( ethanol) is probably the most used drug for anxiety. What is the closest prescription medicine that has the same effects , ( hopefully without the impairment)?
JB
Posted by Phillipa on September 16, 2007, at 11:03:05
In reply to Closest anxiety med to alcohol?, posted by Jimmyboy on September 15, 2007, at 18:45:41
Is there one? Bet it's chloryl hydrate. Phillipa
Posted by saturn on September 16, 2007, at 13:42:44
In reply to Re: Closest anxiety med to alcohol? » Jimmyboy, posted by Phillipa on September 16, 2007, at 11:03:05
Posted by cactus on September 16, 2007, at 17:22:04
In reply to benzodiazepine (nm) » Phillipa, posted by saturn on September 16, 2007, at 13:42:44
I'd say valium
Posted by Phillipa on September 16, 2007, at 19:17:53
In reply to Re: benzodiazepine, posted by cactus on September 16, 2007, at 17:22:04
Disagree friendly as when I was drinking beer nightly the pdoc switched me to chloral hydrate a lot like alchohol from the late l800's I'll do a search and on valium now and no comparison to alchohol at all to me. Phillipa
Posted by Phillipa on September 16, 2007, at 19:26:44
In reply to benzodiazepine (nm) » Phillipa, posted by saturn on September 16, 2007, at 13:42:44
Gotta read more on this as I think just found out how I lost my taste and smell three years ago while taking it. Phillipa
Chloral hydrate
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Chloral hydrate
Systematic (IUPAC) name
2,2,2-trichloroethane-1,1-diol
Identifiers
CAS number 302-17-0
ATC code N05CC01
PubChem 2707
DrugBank ?
Chemical data
Formula C2H3Cl3O2
Mol. mass 165.5 g/mol
Pharmacokinetic data
Bioavailability well absorbed
Metabolism converted to trichloroethanol, hepatic and renal
Half life 8–10 hours in plasma
Excretion bile, feces, urine (various metabolites not unchanged)
Therapeutic considerations
Pregnancy cat. C(US)
Legal status Schedule IV(US)
Routes Oral capsule/syrup, rectal suppository
Chloral hydrate, also known as trichloroacetaldehyde monohydrate, 2,2,2-trichloro-1,1-ethanediol, and under the tradenames Aquachloral, Novo-Chlorhydrate, Somnos, Noctec, and Somnote, is a sedative and hypnotic drug as well as a chemical reagent and precursor. Its chemical formula is C2H3Cl3O2.It was discovered through the chlorination of ethanol in 1832 by Justus von Liebig in Gießen. It was widely abused and misprescribed in the late 19th century. Chloral hydrate is soluble in both water and alcohol, readily forming concentrated solutions. A solution of chloral hydrate in alcohol called "knockout drops" was used to prepare a Mickey Finn.
It is a minor side-product of the chlorination of water, concentrations rarely exceeding 5 micrograms per litre (µg/l).
Contents [hide]
1 Uses
2 See also
3 Chloral in fiction
4 See Also
5 Sources
6 External links
[edit] Uses
It is used for the short-term treatment of insomnia and as a sedative before minor medical or dental treatment. It has been largely displaced by the development of benzodiazepines. It was also formerly used as in veterinary medicine as a general anesthetic. Today, it is commonly used as an ingredient in the veterinary anesthetic Equithesin.In therapeutic doses for insomnia it is effective within sixty minutes, it is metabolized within 4 minutes into trichloroethanol by erythrocytes and plasma esterases and many hours later into trichloroacetic acid. Higher doses can depress respiration and blood pressure. An overdose is marked by confusion, convulsions, nausea and vomiting, severe drowsiness, slow and irregular breathing, cardiac arrhythmia and weakness. It may also cause liver damage. It is moderately addictive. Chronic use can cause dependency and withdrawal symptoms. It can potentiate various anticoagulants and is weakly mutagenic in vitro and in vivo.
The corresponding anhydrous aldehyde, chloral, is used as an intermediate in insecticide and herbicide manufacture (including DDT, dichlorvos, and naled). Chloral reacts rapidly with water to form chloral hydrate.
Chloral hydrate is now illegal in the United States without a prescription. Chloral hydrate is a schedule IV controlled substance in the United States. Its properties sometimes lead to its use as a date rape
Posted by cactus on September 16, 2007, at 22:50:48
In reply to Re: benzodiazepine, posted by Phillipa on September 16, 2007, at 19:26:44
I see your point phillipa but who would prescribe it these days. It would be almost impossible to get a hold of it since benzo's came along.
Posted by Phillipa on September 16, 2007, at 23:32:51
In reply to Re: benzodiazepine » Phillipa, posted by cactus on September 16, 2007, at 22:50:48
Cactus believe it or not I was on it until about 2 years ago. I call him the bad pdoc as he had me on it for years. It's still out there and bet he's still prescribing it. He treats most of the Viet Nam Vets. Was in trouble with the government for insurance fraud. Phillipa and the hospital I worked at then were the ones who only used him in employee assistance. I said I wanted another one they said no.
Posted by Jimmyboy on September 17, 2007, at 9:10:31
In reply to Re: benzodiazepine » cactus, posted by Phillipa on September 16, 2007, at 23:32:51
Was wondering if someone could compare the following benzo's for me : As in terms of effects, length of action , effectiveness, sedation, etc. Also are some better for certain conditions, ie. - social phobia vs GAD, v random pobias? Or do they all just kind of do the same thing?
Valium - Klonopin - Ativan
ThanksJB
Posted by twinch42085 on September 17, 2007, at 16:16:26
In reply to Can someone compare these benzo's for me?, posted by Jimmyboy on September 17, 2007, at 9:10:31
Goto this website:
http://www.crazymeds.org/benzo.html
It has a lot of information about benzos. It describes most of the things that you are asking about.
Goodluck : )
twinch
Posted by cactus on September 18, 2007, at 0:41:40
In reply to Re: Can someone compare these benzo's for me? » Jimmyboy, posted by twinch42085 on September 17, 2007, at 16:16:26
it's a good site it makes me laugh, they just say it how it is for some people. I found one reference to a drug reaction I had that was nowhere else to be found. It really made me laugh but it wasn't a nice side effect but at least someone took the time out to document it!!!!!!
Posted by Mishal on September 18, 2007, at 2:41:00
In reply to Can someone compare these benzo's for me?, posted by Jimmyboy on September 17, 2007, at 9:10:31
> Was wondering if someone could compare the following benzo's for me :
> Valium - Klonopin - AtivanValium: High euphoria. Very effective for anxiety and insomnia. Not pretty effective for panic attacks. Very long acting.
Klonopin: Mild euphoria. Effective for both anxiety and panic. Long acting and depressing as it wears off.
Ativan: Moderate euphoria. Effective for anxiety. Sedating, but not to the degree of valium. Intermediate acting.
Xanax: High euphoria. Golden standard of anxiety and panic. But short acting.
Posted by Jimmyboy on September 18, 2007, at 8:38:15
In reply to Re: Can someone compare these benzo's for me? » Jimmyboy, posted by Mishal on September 18, 2007, at 2:41:00
Thanks for the input,
I am switching from Klonopin to Ativan, so I really appreciate the information!
Posted by rina on September 22, 2007, at 22:33:32
In reply to Closest anxiety med to alcohol?, posted by Jimmyboy on September 15, 2007, at 18:45:41
I'd have to agree with cactus by saying Valium. Only because take for instance ethanol, once it gets into the bloodstream, there's two places for it to go. The brain and the liver but we'll focus just on the brain for now.
Once ethanol is in the brain it acts as a stimulant and a deppressant, becoming more of a depressant as you consume higher levels of ethanol. But the "buzz" you get is from the "pleasure" center of the brain.
This is where ethanol tends to give off that reduction in the anxiety center of the brain, which leads to calming and reduced anxiety much like Valium, in my opinion.
This is the end of the thread.
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