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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on August 31, 2007, at 21:41:07
In this model, freewheel running produces adaptive changes in the 5-ht1a serotonin autoreceptor. It appears to increase the sensitivity of the autoreceptor which would reduce serotonin release.
Apparently this reduced serotonin release reduces anxiety.
http://www.jneurosci.org/cgi/content/full/23/7/2889
Linkadge
Posted by Phillipa on August 31, 2007, at 22:24:20
In reply to Hyperserotonergic model of anxiety, posted by linkadge on August 31, 2007, at 21:41:07
Link you know I don't all this stuff but am I correct in saying that a rat being allowed to run or excercise after a shock reduced anxiety? Is that part of it anyway? Phillipa
Posted by saturn on September 1, 2007, at 11:26:04
In reply to Hyperserotonergic model of anxiety, posted by linkadge on August 31, 2007, at 21:41:07
This is interesting. So is the 5-ht1a autoreceptor analagous to the alpha-2 noradrenergic autoreceptor?
A single 50 mg dose of Zoloft gave me the most intense anxiety I've ever experienced. I wonder if this could have something to do with it.
Posted by iforgotmypassword on September 2, 2007, at 11:46:31
In reply to Hyperserotonergic model of anxiety, posted by linkadge on August 31, 2007, at 21:41:07
Posted by linkadge on September 3, 2007, at 18:11:42
In reply to akathisia is an antidepressant? (nm), posted by iforgotmypassword on September 2, 2007, at 11:46:31
This is the end of the thread.
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