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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Klavot on August 8, 2007, at 8:04:27
Is the following claim correct?
"Norfluoxetine is the only active metabolite of fuoxetine. Therefore the antidepressant effect of fluoxetine is entirely due to norfluoxetine."
Klavot
Posted by Larry Hoover on August 8, 2007, at 9:23:15
In reply to Norfluoxetine, posted by Klavot on August 8, 2007, at 8:04:27
> Is the following claim correct?
>
> "Norfluoxetine is the only active metabolite of fuoxetine. Therefore the antidepressant effect of fluoxetine is entirely due to norfluoxetine."
>
> KlavotI don't know where you found this quotation, but it's a misinterpretation of the pharmacokinetic data. Prozac is supplied as a racemic mixture of R- and S- enantiomers, both of which are roughly equal in antidepressant effect. Of all the metabolites, S-norfluoxetine is also considered to be of similar antidepressant effect, and it has a longer half-life than its parent. R-norfluoxetine is both less active, and better eliminated, so it is of little consequence.
Poor metabolizers at 2D6 produce less S-norfluoxetine, but because the parent is active, it is considered to be of little therapeutic consequence.
Lar
Posted by Klavot on August 9, 2007, at 4:20:03
In reply to Re: Norfluoxetine » Klavot, posted by Larry Hoover on August 8, 2007, at 9:23:15
Posted by Larry Hoover on August 9, 2007, at 6:26:54
In reply to Re: Thank you so much Larry (nm), posted by Klavot on August 9, 2007, at 4:20:03
Sir, I am in your debt. I am most grateful that you found a way to get the blocking formula changed to something more reasonable. I meant to say something on Admin, but I never found the words.
Lar
Posted by Klavot on August 10, 2007, at 5:52:11
In reply to Re: Thank you so much Klavot » Klavot, posted by Larry Hoover on August 9, 2007, at 6:26:54
That's very kind of you Larry. Though it was a collective effort, many other people made useful suggestions as well.
Klavot
This is the end of the thread.
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