Psycho-Babble Medication Thread 774750

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Norfluoxetine

Posted by Klavot on August 8, 2007, at 8:04:27

Is the following claim correct?

"Norfluoxetine is the only active metabolite of fuoxetine. Therefore the antidepressant effect of fluoxetine is entirely due to norfluoxetine."

Klavot

 

Re: Norfluoxetine » Klavot

Posted by Larry Hoover on August 8, 2007, at 9:23:15

In reply to Norfluoxetine, posted by Klavot on August 8, 2007, at 8:04:27

> Is the following claim correct?
>
> "Norfluoxetine is the only active metabolite of fuoxetine. Therefore the antidepressant effect of fluoxetine is entirely due to norfluoxetine."
>
> Klavot

I don't know where you found this quotation, but it's a misinterpretation of the pharmacokinetic data. Prozac is supplied as a racemic mixture of R- and S- enantiomers, both of which are roughly equal in antidepressant effect. Of all the metabolites, S-norfluoxetine is also considered to be of similar antidepressant effect, and it has a longer half-life than its parent. R-norfluoxetine is both less active, and better eliminated, so it is of little consequence.

Poor metabolizers at 2D6 produce less S-norfluoxetine, but because the parent is active, it is considered to be of little therapeutic consequence.

Lar

 

Re: Thank you so much Larry (nm)

Posted by Klavot on August 9, 2007, at 4:20:03

In reply to Re: Norfluoxetine » Klavot, posted by Larry Hoover on August 8, 2007, at 9:23:15

 

Re: Thank you so much Klavot » Klavot

Posted by Larry Hoover on August 9, 2007, at 6:26:54

In reply to Re: Thank you so much Larry (nm), posted by Klavot on August 9, 2007, at 4:20:03

Sir, I am in your debt. I am most grateful that you found a way to get the blocking formula changed to something more reasonable. I meant to say something on Admin, but I never found the words.

Lar

 

Re: Thank you so much Klavot » Larry Hoover

Posted by Klavot on August 10, 2007, at 5:52:11

In reply to Re: Thank you so much Klavot » Klavot, posted by Larry Hoover on August 9, 2007, at 6:26:54

That's very kind of you Larry. Though it was a collective effort, many other people made useful suggestions as well.

Klavot


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